A New Ellagic Acid Rhamnoside from Synadenium glaucescens and Its Cytotoxicity Evaluation

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A phytochemical investigation of the ethyl acetate fraction of root bark extract of Synadenium glaucescens Pax (Euphorbiaceae) led to the isolation of two derivatives of ellagic acid. These included one new 3′,4′ -di-O-methylellagic acid-4α, L-rhamnopyranoside (1) and a known 3,4,3′-tri-O-methylellagic acid (2). Their structures were elucidated by 1D and 2D NMR, while a High res. MS (FTMS-ESI) was used for accurate mass measurement, which was compared with SciFinder data as well as with available literature. The BSLT results indicated that both 1 (LC50 = 2736.03 μg/mL) and 2 (LC50 = 531.19 μg/mL) were nontoxic at a maximum test concentration of 2400 ppm.

Original languageEnglish
JournalChemistry of Natural Compounds
Issue number4
Pages (from-to)670-674
Publication statusPublished - 2023

Bibliographical note

Funding Information:
The authors acknowledge the financial support from Green Resources Innovations for Livelihood Improvement (GRILI-DANIDA) project (Grant No. 18-3-TAN). Also Mr. Christopher Johnson Mwankuna from the Department of Chemistry and Physics, Sokoine University of Agriculture, Morogoro, Tanzania and Mr. Christian Janflet from the Department of Pharmacy, University of Copenhagen, Denmark are acknowledged for their technical support. The NMR equipment used in this work was purchased via Grant No. 10-085264 from The Danish Research Council for Independent Research, Nature and Universe.

Publisher Copyright:
© 2023, Springer Science+Business Media, LLC, part of Springer Nature.

    Research areas

  • anticancer, antimicrobial, antioxidant, brine shrimp, ellagic acid, Euphorbiaceae, phenolics, rhamnose, Synadenium glaucescens

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