TY - JOUR

T1 - A New Ellagic Acid Rhamnoside from Synadenium glaucescens and Its Cytotoxicity Evaluation

AU - Rwegoshora, F.

AU - Mabiki, F.

AU - Machumi, F.

AU - Chacha, M.

AU - Styrishave, B.

AU - Cornett, C.

N1 - Funding Information: The authors acknowledge the financial support from Green Resources Innovations for Livelihood Improvement (GRILI-DANIDA) project (Grant No. 18-3-TAN). Also Mr. Christopher Johnson Mwankuna from the Department of Chemistry and Physics, Sokoine University of Agriculture, Morogoro, Tanzania and Mr. Christian Janflet from the Department of Pharmacy, University of Copenhagen, Denmark are acknowledged for their technical support. The NMR equipment used in this work was purchased via Grant No. 10-085264 from The Danish Research Council for Independent Research, Nature and Universe. Publisher Copyright: © 2023, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2023

Y1 - 2023

N2 - A phytochemical investigation of the ethyl acetate fraction of root bark extract of Synadenium glaucescens Pax (Euphorbiaceae) led to the isolation of two derivatives of ellagic acid. These included one new 3′,4′ -di-O-methylellagic acid-4α, L-rhamnopyranoside (1) and a known 3,4,3′-tri-O-methylellagic acid (2). Their structures were elucidated by 1D and 2D NMR, while a High res. MS (FTMS-ESI–) was used for accurate mass measurement, which was compared with SciFinder data as well as with available literature. The BSLT results indicated that both 1 (LC50 = 2736.03 μg/mL) and 2 (LC50 = 531.19 μg/mL) were nontoxic at a maximum test concentration of 2400 ppm.

AB - A phytochemical investigation of the ethyl acetate fraction of root bark extract of Synadenium glaucescens Pax (Euphorbiaceae) led to the isolation of two derivatives of ellagic acid. These included one new 3′,4′ -di-O-methylellagic acid-4α, L-rhamnopyranoside (1) and a known 3,4,3′-tri-O-methylellagic acid (2). Their structures were elucidated by 1D and 2D NMR, while a High res. MS (FTMS-ESI–) was used for accurate mass measurement, which was compared with SciFinder data as well as with available literature. The BSLT results indicated that both 1 (LC50 = 2736.03 μg/mL) and 2 (LC50 = 531.19 μg/mL) were nontoxic at a maximum test concentration of 2400 ppm.

KW - anticancer

KW - antimicrobial

KW - antioxidant

KW - brine shrimp

KW - ellagic acid

KW - Euphorbiaceae

KW - phenolics

KW - rhamnose

KW - Synadenium glaucescens

U2 - 10.1007/s10600-023-04083-8

DO - 10.1007/s10600-023-04083-8

M3 - Journal article

AN - SCOPUS:85168201740

VL - 59

SP - 670

EP - 674

JO - Khimiya Prirodnykh Soedinenii

JF - Khimiya Prirodnykh Soedinenii

SN - 0023-1150

IS - 4

ER -