Holger Grohganz
Associate Professor
Solid State Pharmaceutics
Universitetsparken 2, 2100 København Ø
Pharmaceuticals, processes and products
Universitetsparken 2
2100 København Ø
- 2003
Quantification of various phosphatidylcholines in liposomes by enzymatic assay
Grohganz, Holger, Ziroli, V., Massing, U. & Brandl, M., 2003, In: AAPS PharmSciTech. 4, 4Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface
Grohganz, Holger, Rischer, M. & Brandl, M., 2004, In: European Journal of Pharmaceutical Sciences. 21, 2-3, p. 191-196Research output: Contribution to journal › Journal article › Research › peer-review
Development and validation of a HPLC method for routine quantification of the decapeptide Cetrorelix in liposome dispersions
Grohganz, Holger, Schläfli, O., Rischer, M. & Brandl, M., 2004, In: Journal of Pharmaceutical and Biomedical Analysis. 34, 5, p. 963-969Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Development and in vitro evaluation of a liposome based implant formulation for the decapeptide cetrorelix
Grohganz, Holger, Tho, I. & Brandl, M., 2005, In: European Journal of Pharmaceutics and Biopharmaceutics. 59, 3, p. 439-448Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Controlling production process: incorporating analytical methods
Grohganz, Holger & Rantanen, Jukka, 2008, In: Pharma focus Asia. 8, p. 82-83Research output: Contribution to journal › Journal article › Communication
- 2009
- Published
Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients
Jørgensen, Lene, Hostrup, S., Møller, E. H. & Grohganz, Holger, 2009, In: Expert Opinion on Drug Delivery. 6, 11, p. 1219-1230Research output: Contribution to journal › Review › Research
- Published
Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy
Grohganz, Holger, Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, Jukka, 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, p. 901-907Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Classification of lyophilised mixtures using multivariate analysis of NIR spectra
Grohganz, Holger, Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, Jukka, 2010, In: European Journal of Pharmaceutics and Biopharmaceutics. 74, p. 406-412Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy
Grohganz, Holger, Gildemyn, D., Skibsted, E., Fink, J. M. & Rantanen, Jukka, 2010, In: Analytica Chimica Acta. 676, p. 34-40Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen
Löbmann, Korbinian, Laitinen, R., Grohganz, Holger, Gordon, K. C., Strachan, C. & Rades, Thomas, 2011, In: Molecular Pharmaceutics. 8, 5, p. 1919-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR
Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In: A A P S PharmSciTech. 12, 2, p. 627-635Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Near-infrared (NIR) spectroscopy – a versatile tool for pharmaceutical research and production
Grohganz, Holger, 2011, In: European Pharmaceutical Review. 16, 2, p. 57-60Research output: Contribution to journal › Journal article › Communication
- Published
Rapid solid-state analysis of freeze-dried protein formulations using NIR and raman spectroscopies
Grohganz, Holger, Gildemyn, D., Skibsted, E., Flink, J. M. & Rantanen, Jukka, 2011, In: Journal of Pharmaceutical Sciences. 100, 7Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions
Löbmann, Korbinian, Strachan, C., Grohganz, Holger, Rades, Thomas, Korhonen, O. & Laitinen, R., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 1, p. 159-69 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy
Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 2012, In: A A P S PharmSciTech. 13, 3, p. 747-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design space approach in the optimization of the spray-drying process
Lebrun, P., Krier, F., Mantanus, J., Grohganz, Holger, Yang, Mingshi, Rozet, E., Boulanger, B., Evrard, B., Rantanen, Jukka & Hubert, P., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 80, 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ordnung muss (nicht) sein
Löbmann, Korbinian, Jensen, K. B. T., Grohganz, Holger & Rades, Thomas, 2012, In: Lægemiddelforskning. 2012, p. 34-36Research output: Contribution to journal › Journal article › Communication
- Published
Quality by design approach in the optimization of the spray-drying process
Baldinger, A., Clerdent, L., Rantanen, Jukka, Yang, Mingshi & Grohganz, Holger, 2012, In: Pharmaceutical Development and Technology. 17, 4, p. 389-397Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin
Priemel, P. A., Grohganz, Holger, Gordon, K. C., Rades, Thomas & Strachan, C., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 187-193Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Amorphous drugs and dosage forms
Grohganz, Holger, Löbmann, Korbinian, Priemel, P., Tarp Jensen, K., Graeser, K., Strachan, C. & Rades, Thomas, 2013, In: Journal of Drug Delivery Science and Technology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions
Löbmann, Korbinian, Laitinen, R., Strachan, C., Rades, Thomas & Grohganz, Holger, 1 Jan 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Part B, p. 882-888Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum to: Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy
Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 21 Feb 2013, In: A A P S PharmSciTech. 14, 2, p. 901 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
The influence of lysozyme on mannitol polymorphism in freeze-dried and spray-dried formulations depends on the selection of the drying process
Grohganz, Holger, Lee, Y., Rantanen, Jukka & Yang, Mingshi, 15 Apr 2013, In: International Journal of Pharmaceutics. 447, 1-2, p. 224-30 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amorphous drugs and dosage forms
Grohganz, Holger, Löbmann, Korbinian, Priemel, P., Jensen, K. B. T., Graeser, K., Strachan, C. & Rades, Thomas, 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 403-408 6 p.Research output: Contribution to journal › Review › Research
- Published
Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis
Chieng, N., Trnka, H., Bøtker, Johan Peter, Pikal, M., Rantanen, Jukka & Grohganz, Holger, 18 Jul 2013, In: International Journal of Pharmaceutics. 454, 1, p. 167-173 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin
Löbmann, Korbinian, Laitinen, R., Grohganz, Holger, Strachan, C. J., Rades, Thomas & Gordon, K. C., 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 80-87 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Emerging trends in the stabilization of amorphous drugs
Laitinen, R., Löbmann, Korbinian, Strachan, C. J., Grohganz, Holger & Rades, Thomas, 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 65-79 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement
Löbmann, Korbinian, Grohganz, Holger, Laitinen, R., Strachan, C. & Rades, Thomas, Nov 2013, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 873-81 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In situ amorphisation of indomethacin with Eudragit® E during dissolution
Priemel, P. A., Laitinen, R., Grohganz, Holger, Rades, Thomas & Strachan, C. J., Nov 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 Pt B, p. 1259-65 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures
Priemel, P. A., Laitinen, R., Barthold, S., Grohganz, Holger, Lehto, V., Rades, Thomas & Strachan, C. J., 18 Nov 2013, In: International Journal of Pharmaceutics. 456, 2, p. 301-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations
Trnka, H., Wu, J., van de Weert, Marco, Grohganz, Holger & Rantanen, Jukka, Dec 2013, In: Journal of Pharmaceutical Sciences. 102, 12, p. 4364-74 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Formulating Amorphous Drug Delivery System Using Low-Molecular-Weight Components as Stabilizers
Löbmann, Korbinian, Laitinen, R., Grohganz, Holger & Rades, Thomas, 2014, In: CRS Newsletter. 31, 3, p. 16-17Research output: Contribution to journal › Journal article › Communication
- Published
Improving co-amorphous drug formulations by the addition of the highly water soluble amino acid proline
Jensen, K. B. T., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 2014, In: Pharmaceutics. 6, 3, p. 416-435 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stabilized amorphous solid dispersions with small molecule excipients
Löbmann, Korbinian, Jensen, K. B. T., Laitinen, R., Rades, Thomas, Strachan, C. & Grohganz, Holger, 2014, Amorphous Solid Dispersions - Theory and Practice. Shah, N., Sandhu, H., Choi, D. S., Chokshi, H. & Malick, A. W. (eds.). New York: Springer Science+Business Media, p. 613-626 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Theoretical Considerations in Developing Amorphous Solid Dispersions
Laitinen, R., Priemel, P. A., Surwase, S., Graeser, K., Strachan, C. J., Grohganz, Holger & Rades, Thomas, 2014, Amorphous Solid Dispersions - Theory and Practice. Shah, N., Sandhu, H., Choi, D. S., Chokshi, H. & Malick, A. W. (eds.). New York: Springer Science+Business Media, p. 35-90 56 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Formation of mannitol hemihydrate in freeze-dried protein formulations-A design of experiment approach
Larsen, H. M. L., Trnka, H. & Grohganz, Holger, 2 Jan 2014, In: International Journal of Pharmaceutics. 460, 1-2, p. 45-52 8 p.Research output: Contribution to journal › Journal article › Research
- Published
Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations
Trnka, H., Palou, A., Panouillot, P. E., Kauppinen, A., Toiviainen, M., Grohganz, Holger, Alcalà, M., Juuti, M., Ketolainen, J. & Rantanen, Jukka, 24 Mar 2014, In: Journal of Pharmaceutical Sciences. 103, 9, p. 2839–2846 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Refining stability and dissolution rate of amorphous drug formulations
Grohganz, Holger, Priemel, P. A., Löbmann, Korbinian, Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In: Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability
Laitinen, R., Löbmann, Korbinian, Grohganz, Holger, Strachan, C. & Rades, Thomas, 7 Jul 2014, In: Molecular Pharmaceutics. 11, 7, p. 2381-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying
Craye, G., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Laitinen, R., 2015, In: Molecules. 20, 12, p. 21532-48 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation mechanism of coamorphous drug−amino acid mixtures
Jensen, K. B. T., Larsen, F. H., Cornett, Claus, Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 2015, In: Molecular Pharmaceutics. 12, 7, p. 2484−2492 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin
Beyer, A., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., 2015, In: Molecules. 20, 10, p. 19571-87 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of polymeric excipients in the stabilization of olanzapine when exposed to aqueous environments
Paisana, M., Wahl, M., Pinto, J., Rades, Thomas (ed.), Grohganz, Holger (ed.) & Löbmann, Korbinian (ed.), 2015, In: Molecules. 20, 12, p. 22634-223282 200649.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Well-plate freeze-drying: a high throughput platform for screening of physical properties of freeze-dried formulations
Trnka, H., Rantanen, Jukka & Grohganz, Holger, 2015, In: Pharmaceutical Development and Technology. 20, 1, p. 65-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media
Heikkinen, A. T., DeClerck, L., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Laitinen, R., Jul 2015, In: Pharmazie. 70, 7, p. 452-457 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin-arginine
Lenz, E., Jensen, K. B. T., Blaabjerg, L. I., Knop, K., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Kleinebudde, P., Oct 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 96, p. 44–52 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Glass forming ability of amorphous drugs investigated by continuous cooling- and isothermal transformation
Blaabjerg, L. I., Lindenberg, E., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 2016, In: Molecular Pharmaceutics. 13, 9, p. 3318-3325 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of variation in molar ratio on co-amorphous drug-amino acid systems
Jensen, K. B. T., Larsen, F. H., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 2016, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 107, p. 32-39 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities
Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage
Sovago, I., Wang, W., Qiu, D., Raijada, D. K., Rantanen, Jukka, Grohganz, Holger, Rades, Thomas, Bond, A. D. & Löbmann, Korbinian, 2016, In: Molecules. 21, 4, p. 1-13 13 p., 509.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1421411
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The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation
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Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations
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The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers
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