Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor

ORCID: 0000-0002-7285-9100

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  1. Published

    Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath

    van Gent, M. E., Kłodzińska, S. N., Severin, M., Ali, M., van Doodewaerd, B. R., Bos, E., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 52, 11 p., 102694.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections

    van Gent, M. E., van Baaren, T., Kłodzińska, S. N., Ali, M., Dolezal, N., van Doodewaerd, B. R., Bos, E., de Waal, A. M., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Pharmaceutics. 15, 2, 20 p., 429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath

    van Gent, M. E., Klodzinska, S. N., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 254-261

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

    de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Corrigendum to "Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites" [J. Colloid Interface Sci. 606(Part 2) (2022) 1928-1939]

    Zhou, X., Galparsoro, D. F., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2023, In: Journal of Colloid and Interface Science. 640, p. 917

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

    Zhou, X., Sinkjær, Anders Wilgaard, Zhang, Min, Pinholt, H. D., Nielsen, Hanne Mørck, Hatzakis, Nikos, van de Weert, Marco & Foderà, Vito, 2023, In: The Journal of Physical Chemistry Letters. 14, 4, p. 912-919

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Polysorbate 80 Controls Morphology, Structure and Stability of Human Insulin Amyloid-Like Spherulites

    Zhou, X., Galparsoro, D. F., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 10 Aug 2021, bioRxiv, 52 p.

    Research output: Working paper › Preprint › Research

  8. Published

    Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites

    Zhou, X., Fennema Galparsoro, D., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2022, In: Journal of Colloid and Interface Science. 606, Pt 2, p. 1928-1939

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

    Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA

    Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

    Research output: Contribution to conference › Conference abstract for conference › Research

  11. Published

    Ca2+-Responsive Glyco-insulin

    Wu, S., Østergaard, M., Fredholt, Freja, Christensen, Niels Johan, Sørensen, K. K., Mishra, N. K., Nielsen, Hanne Mørck & Jensen, Knud Jørgen, 2023, In: Bioconjugate Chemistry. 34, 3, p. 518–528

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration

    Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, 2012, In: Biomacromolecules. 13, p. 905-917

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Development of biodegradable nanocomposite scaffolds for autologous cell therapy

    Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 1 Jan 2011, In: European Cells and Materials. 21, SUPPL.1, 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds

    Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 2011, In: Journal of Controlled Release. 156, 1, p. 11-20

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs

    Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, Sep 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 1, p. 87-98 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration

    Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, L., Møller, E. H. & Nielsen, Hanne Mørck, 2012, In: Biomacromolecules. 13, p. 905-917

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial

    Weiss, A., Delavenne, E., Matias, C., Lagler, H., Simon, D., Li, P., Hansen, J. U., Dos Santos, T. P., Jana, B., Priemel, P., Bangert, C., Bauer, M., Eberl, S., Nussbaumer-Pröll, A., Anne Österreicher, Z., Matzneller, P., Quint, T., Weber, M., Nielsen, H. M., Rades, T. & 17 others, Johansen, Helle Krogh, Westh, Henrik T., Kim, W., Mylonakis, E., Friis, C., Guardabassi, Luca, Pace, J., Lundberg, C. V., M'Zali, F., Butty, P., Sørensen, N., Nielsen, H. B., Toft-Kehler, R., Guttman-Yassky, E., Stingl, G., Zeitlinger, M. & Sommer, M., 2022, In: Clinical and Translational Medicine. 12, 5, e790.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line

    Water, J. J., Foged, C., Franzyk, H. & Nielsen, Hanne Mørck, 2013.

    Research output: Contribution to conference › Poster › Research › peer-review

  19. Published

    Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line

    Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2013.

    Research output: Contribution to conference › Poster › Research › peer-review

  20. Published

    Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics

    Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.

    Research output: Contribution to conference › Poster › Research › peer-review

  21. Published

    Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells

    Water, J. J., Smart, S., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 18 Feb 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92, p. 65-73 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

    Water, J. J., Bohr, A., Bøtker, Johan Peter, Aho, J., Sandler, N., Nielsen, Hanne Mørck & Rantanen, Jukka, 15 Jan 2015, In: Journal of Pharmaceutical Sciences. p. 1099–1107 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics

    Water, J. J., Maltesen, M. J., Foged, C., Franzyk, H. & Nielsen, Hanne Mørck, 2014.

    Research output: Contribution to conference › Poster › Research › peer-review

  24. Published

    Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin

    Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

    Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

    Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    A free-floating mucin layer to investigate the effect of the local microenvironment in lungs on mucin-nanoparticle interactions

    Wan, F., Herzberg, M., Huang, Z., Hassenkam, Tue & Nielsen, Hanne Mørck, 2020, In: Acta Biomaterialia. 104, 1, p. 115-123

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

    Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities

    Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats

    Vargas Christensen, I., Loftager, M., Rode, F., Nielsen, Hanne Mørck, Kreilgaard, M. & Larsen, M. S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 6, p. 964-974 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models

    Tréhin, R., Krauss, U., Beck-Sickinger, A. G., Merkle, H. P. & Nielsen, Hanne Mørck, 2004, In: Pharmaceutical Research. 21, 7, p. 1248-56 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58)

    Tréhin, R., Nielsen, Hanne Mørck, Jahnke, H., Krauss, U., Beck-Sickinger, A. G. & Merkle, H. P., 2004, In: Biochemical Journal. 382, Pt 3, p. 945-56 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals

    Tollemeto, M., Huang, Z., Christensen, Jørn Bolstad, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: ACS Applied Materials and Interfaces. 15, 7, p. 8798–8810

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

    Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, Foged, Camilla, 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  35. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs

    Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

    Research output: Contribution to conference › Poster › Research

  36. Published

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

    Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

    Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.

    Research output: Contribution to conference › Poster › Research

  38. Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.

    Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Ogris, M., Nielsen, Hanne Mørck & Foged, C., 2016.

    Research output: Contribution to conference › Poster › Research

  39. Published

    Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach

    Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

    Te Boekhorst, B. C. M., Jensen, L. B., Colombo, S., Varkouhi, A. K., Schiffelers, R. M., Lammers, T., Storm, G., Nielsen, Hanne Mørck, Strijkers, G. J., Foged, Camilla & Nicolay, K., 2012, In: Journal of controlled release : official journal of the Controlled Release Society. 161, 3, p. 772-80 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

    Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking

    Streck, S., Bohr, S. S., Birch, D., Rades, Thomas, Hatzakis, Nikos, McDowell, A. & Nielsen, Hanne Mørck, 2021, In: ACS Applied Bio Materials. 4, 4, p. 3155-3165 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures

    Streck, S., Neumann, H., Nielsen, Hanne Mørck, Rades, Thomas & McDowell, A., Dec 2019, In: International Journal of Pharmaceutics: X. 1, 9 p., 100030.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering

    Streck, S., Clulow, A. J., Nielsen, Hanne Mørck, Rades, Thomas, Boyd, B. J. & McDowell, A., 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 438-448 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Cyclodextrins: efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems

    Stojanov, M., Nielsen, Hanne Mørck & Larsen, K. L., 2012, In: International Journal of Pharmaceutics. 422, 1-2, p. 349-355

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

    Stie, Mai Bay, Öblom, H., Hansen, Anders Christian Nørgaard, Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

    Stie, Mai Bay, Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 15 Aug 2020, In: Carbohydrate Polymers. 242, 10 p., 116428.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

    Stie, Mai Bay, Corezzi, M., Juncos Bombin, A. D., Ajalloueian, F., Attrill, E., Pagliara, S., Jacobsen, Jette, Chronakis, I. S., Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: ACS Applied Nano Materials. 3, 2, p. 1910–1921

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

    Stie, Mai Bay, Jones, M., Sørensen, H. O., Jacobsen, Jette, Chronakis, I. S. & Nielsen, Hanne Mørck, 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

    Stie, Mai Bay, Gätke, J. R., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1299091