Christian Janfelt
Associate Professor - Promotion Programme
Toxicology and Drug Metabolism
Universitetsparken 2
2100 København Ø
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Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging
Kucharíková, A., Kimáková, K., Janfelt, Christian & Cellárová, E., 2016, In: Physiologia Plantarum. 157, 1, p. 2-12 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct imaging of plant metabolites in leaves and petals by Desorption Electrospray Ionization mass spectrometry
Li, B., Hansen, S. H. & Janfelt, Christian, 2013, In: International Journal of Mass Spectrometry. 348, p. 15-22Research output: Contribution to journal › Journal article › Research › peer-review
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Direct and indirect imaging of secondary metabolites and enzymatic reactions in plant material by Desorption Electrospray Ionization
Li, B., Bjarnholt, Nanna, Knudsen, C., D'Alvise, J., Hansen, S. H. & Janfelt, Christian, 2012.Research output: Contribution to conference › Poster › Research › peer-review
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Visualizing metabolite distribution and enzymatic conversion in plant tissues by desorption electrospray ionization mass spectrometry imaging
Li, B., Baden, C. K., Hansen, N. K. K., Jørgensen, Kirsten, Kannangara, R. M., Bak, Søren, Takos, A. M., Rook, F., Hansen, S. H., Møller, Birger Lindberg, Janfelt, Christian & Bjarnholt, Nanna, 2013, In: Plant Journal. 74, 6, p. 1059-1071 74.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of barley leaf tissue using direct and indirect desorption electrospray ionization imaging mass spectrometry
Li, B., Bjarnholt, Nanna, Hansen, S. H. & Janfelt, Christian, 2011, In: Journal of Mass Spectrometry. 46, 12, p. 1241-1246Research output: Contribution to journal › Journal article › Research › peer-review
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Natural products in Glycyrrhiza glabra (licorice) rhizome imaged at the cellular level by atmospheric pressure matrix-assisted laser desorption/ionization tandem mass spectrometry imaging
Li, B., Bhandari, D. R., Janfelt, Christian, Römpp, A. & Spengler, B., Oct 2014, In: Plant Journal. 80, 1, p. 161-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging
Lorensen, Marcus Daniel B B, Bjarnholt, Nanna, St-Pierre, B., Heinicke, S., Courdavault, V., O'Connor, S. & Janfelt, Christian, 2023, In: Phytochemistry. 209, 15 p., 113620.Research output: Contribution to journal › Journal article › Research › peer-review
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Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids
Lorensen, Marcus Daniel B B, Hayat, S. Y., Wellner, N., Bjarnholt, Nanna & Janfelt, Christian, 2023, In: Phytochemical Analysis. 34, 3, p. 269-279Research output: Contribution to journal › Journal article › Research › peer-review
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Tissue-specific stilbene accumulation is an early response to wounding/grafting as revealed by using spatial and temporal metabolomics
Loupit, G., Fonayet, J. V., Lorensen, Marcus Daniel B B, Franc, C., De Revel, G., Janfelt, Christian & Cookson, S. J., 2023, In: Plant Cell and Environment. 46, 12, p. 3871-3886Research output: Contribution to journal › Journal article › Research › peer-review
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Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging
Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging
Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.Research output: Contribution to journal › Journal article › Research › peer-review
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Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect
Meng-Lund, E., Jacobsen, Jette, Jin, L., Janfelt, Christian, Holm, R., Mullertz, Anette & Nicolazzo, J. A., 15 Feb 2014, In: Journal of Pharmaceutical Sciences. 103, 4, p. 1133-1141 103.Research output: Contribution to journal › Journal article › Research › peer-review
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Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination
Montini, L., Crocoll, C., Gleadow, R. M., Motawia, M. S., Janfelt, Christian & Bjarnholt, Nanna, 2020, In: Plant Physiology. 183, 3, p. 925-942 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice
Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, Harald S. & Janfelt, Christian, 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163Research output: Contribution to journal › Journal article › Research › peer-review
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Characterisation and localisation of the endocannabinoid system components in the adult human testis
Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, Christian, Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, Anders, Chalmel, F., Jégou, B. & Skakkebæk, Niels Erik, 2019, In: Scientific Reports. 9, 1, 14 p., 12866.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia
Nielsen, M. M. B., Lambertsen, K. L., Clausen, B. H., Meyer, M., Bhandari, D. R., Larsen, S. T., Poulsen, Steen Seier, Spengler, B., Janfelt, Christian & Hansen, Harald S., 22 Dec 2016, In: Scientific Reports. 6, p. 1-14 14 p., 39571.Research output: Contribution to journal › Journal article › Research › peer-review
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Nebulization ionization and desorption ionization analysis of reactive organofunctionalized silanes in nanofilm products
Nørgaard, A. W., Janfelt, Christian, Benassi, M., Wolkoff, P. & Lauritsen, F. R., 2011, In: Journal of Mass Spectrometry. 46, 4, p. 402-410Research output: Contribution to journal › Journal article › Research › peer-review
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Release of VOCs and particles during use of nanofilm spray products
Nørgaard, A. W., Jensen, K. A., Janfelt, Christian, Lauritsen, F. R., Clausen, P. A. & Wolkoff, P., 2009, In: Environmental Science and Technology. 43, 20, p. 7824-7830 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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On-line monitoring of VOC emissions from nanofilm coating products using a handheld membrane inlet mass spectrometer
Nørgaard, A. W., Janfelt, Christian, Wolkoff, P., Jensen, K. A. & Lauritsen, F. R., 2008.Research output: Contribution to conference › Poster › Research
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Cryo-sectioning of mice for whole-body imaging of drugs and metabolites with desorption electrospray ionization mass spectrometry imaging - a simplified approach
Okutan, S., Hansen, Harald S. & Janfelt, Christian, Jun 2016, In: Proteomics. 16, 11-12, p. 1633-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of midazolam metabolism in locusts: The role of CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam
Olsen, L. R., Gabel-Jensen, C., Wubshet, S. G., Kongstad, Kenneth Thermann, Janfelt, Christian, Badolo, L. & Hansen, S. H., 2016, In: Xenobiotica. 46, 2, p. 99–107 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of an insect model for drug metabolism by Desorption Electrospray Ionization Mass Spectrometry Imaging
Olsen, L. R., Hansen, S. H. & Janfelt, Christian, Aug 2014.Research output: Contribution to conference › Poster › Research
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Distribution of terfenadine and its metabolites in locusts studied by desorption electrospray ionization mass spectrometry imaging
Olsen, L. R., Hansen, S. H. & Janfelt, Christian, 2015, In: Analytical and Bioanalytical Chemistry. 407, 8, p. 2149–2158 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin
Otterbach, S. L., Yang, T., Kato, L., Janfelt, Christian & Geu-Flores, Fernando, 15 Oct 2019, In: Journal of Experimental Botany. 70, 20, p. 5799-5808Research output: Contribution to journal › Journal article › Research › peer-review
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Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219Research output: Contribution to journal › Journal article › Research › peer-review
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The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier
Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.Research output: Contribution to conference › Poster › Research › peer-review
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Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice
Pihl, Celina, Granborg, J. R., Pinto, F. E., Bjerring, P., Andersen, F., Janfelt, Christian, Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, In: Phytomedicine Plus. 4, 2, 8 p., 100547.Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating the spatial distribution of organic contaminants and their biotransformation products in amphipod tissue by MALDI- and DESI-MS-imaging
Raths, J., Pinto, F. E., Janfelt, Christian & Hollender, J., 2023, In: Ecotoxicology and Environmental Safety. 264, 10 p., 115468.Research output: Contribution to journal › Journal article › Research › peer-review
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Importance of Dietary Uptake for in Situ Bioaccumulation of Systemic Fungicides Using Gammarus pulex as a Model Organism
Raths, J., Schnurr, J., Bundschuh, M., Pinto, F. E., Janfelt, Christian & Hollender, J., 2023, In: Environmental Toxicology and Chemistry. 42, 9, p. 1993-2006Research output: Contribution to journal › Journal article › Research › peer-review
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A Comparison of Human and Porcine Skin in Laser-Assisted Drug Delivery of Chemotherapeutics
Rosenberg, L. K., Bagger, C., Janfelt, Christian, Hædersdal, Merete, Olesen, U. H. & Lerche, Catharina Margrethe, 2021, In: Lasers in Surgery and Medicine. 53, 1, p. 162-170 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High-throughput analysis of drugs in biological fluids by desorption electrospray ionization mass spectrometry coupled with thin liquid membrane extraction
Rosting, C., Pedersen-Bjergaard, Stig, Hansen, S. H. & Janfelt, Christian, 2013, In: Analyst. 138, 20, p. 5965-72 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids
Stander, E. A., Lehka, B., Carqueijeiro, I., Cuello, C., Hansson, F. G., Jansen, H. J., Dugé De Bernonville, T., Birer Williams, C., Vergès, V., Lezin, E., Lorensen, M. D. B. B., Dang, T. T., Oudin, A., Lanoue, A., Durand, M., Giglioli-Guivarc’h, N., Janfelt, C., Papon, N., Dirks, R. P., O’connor, S. E. & 3 others, , 2023, In: Communications Biology . 6, 1, 19 p., 1197.Research output: Contribution to journal › Journal article › Research › peer-review
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Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging
Strindberg, S., Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197Research output: Contribution to journal › Journal article › Research › peer-review
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Combination of MALDI-MSI and cassette dosing for evaluation of drug distribution in human skin explant
Sørensen, I. S., Janfelt, Christian, Nielsen, M. M. B., Mortensen, R. W., Knudsen, N. Ø., Eriksson, A. H., Pedersen, A. J. & Nielsen, K. T., Aug 2017, In: Analytical and Bioanalytical Chemistry. 409, 21, p. 4993-5005 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Topically applied methotrexate is rapidly delivered into skin by fractional laser ablation
Taudorf, E. H., Lerche, C., Vissing, A., Philipsen, P. A., Hannibal, Jens, D'Alvise, U. J. C., Hansen, S. H., Janfelt, Christian, Paasch, U., Anderson, R. R. & Hædersdal, Merete, 2015, In: Expert Opinion on Drug Delivery. 12, 7, p. 1059-1069 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fractional laser-assisted drug delivery: Laser channel depth influences biodistribution and skin deposition of methotrexate
Taudorf, E. H., Lerche, C. M., Erlendsson, A. M., Philipsen, P. A., Hansen, S. H., Janfelt, Christian, Paasch, U., Anderson, R. R. & Hædersdal, Merete, Jul 2016, In: Lasers in Surgery and Medicine. 48, 5, p. 519-529 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone
Thakur, A., Pinto, F. E., Hansen, Harald S., Andersen, Peter, Christensen, D., Janfelt, Christian & Foged, Camilla, 2020, In: Frontiers in Immunology. 11, p. 803Research output: Contribution to journal › Journal article › Research › peer-review
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Liquid-phase microextraction and desorption electrospray ionization mass spectrometry for identification and quantification of basic drugs in human urine
Thunig, J., Flø, L., Pedersen-Bjergaard, Stig, Hansen, S. H. & Janfelt, Christian, 2012, In: Rapid Communications in Massspectrometry. 26, 2, p. 133-140Research output: Contribution to journal › Journal article › Research › peer-review
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Direkte analyse med DESI-MS
Thunig, J., Lauritsen, F. R., Hansen, S. H., Janfelt, Christian & Christophersen, C., 2010, In: Dansk Kemi. 91, 3, p. 21-23 3 p.Research output: Contribution to journal › Journal article › Research
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Analysis of secondary plant metabolites by indirect desorption electrospray ionization imaging mas spectrometry
Thunig, U. J. C., Hansen, S. H. & Janfelt, Christian, 2011, In: Analytical Chemistry. 83, p. 3256-3259Research output: Contribution to journal › Letter › Research › peer-review
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Quantitative Mass Spectrometry Imaging of Bleomycin in Skin Using a Mimetic Tissue Model for Calibration
Traberg, A., Pinto, F. E., Hansen, A. C. N., Hædersdal, Merete, Lerche, Catharina Margrethe & Janfelt, Christian, 2022, In: Pharmaceuticals. 15, 12, 15 p., 1583.Research output: Contribution to journal › Journal article › Research › peer-review
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N-acylation of phosphatidylethanolamine and its biological functions in mammals
Wellner, N., Diep, T. A., Janfelt, Christian & Hansen, Harald S., Mar 2013, In: BBA General Subjects. 1831, 3, p. 652-62 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma
Wenande, E., Hendel, K., Mogensen, Mette, Bagger, C., Mårtensson, Nina Løth, Persson, Daniel Pergament, Lerche, C. M., Husted, Søren, Janfelt, Christian, Togsverd‐bo, K., Anderson, R. R. & Hædersdal, Merete, 2021, In: Lasers in Surgery and Medicine. 53, 1, p. 119-128 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fractional laser-assisted topical delivery leads to enhanced, accelerated and deeper cutaneous 5-fluorouracil uptake
Wenande, E., Olesen, U. H., Nielsen, M. M. B., Janfelt, Christian, Hansen, S. H., Anderson, R. & Hædersdal, Merete, 2017, In: Expert Opinion on Drug Delivery. 14, 3, p. 307-317 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 8407
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The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham.) K. Schum Leaves Analysed by Desorption Electrospray Ionisation Mass Spectrometry Imaging
Research output: Contribution to journal › Journal article › Research › peer-review
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The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia
Research output: Contribution to journal › Journal article › Research › peer-review
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Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging
Research output: Contribution to journal › Journal article › Research › peer-review
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