Vaccine Design and Delivery

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  1. 2024
  2. Published

    Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies

    Eş, I., Thakur, A., Mousavi Khaneghah, A., Foged, Camilla & de la Torre, L. G., 2024, In: Biotechnology Advances. 72, 45 p., 108342.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies

    Eş, I., Thakur, A., Mousavi Khaneghah, A., Foged, Camilla & de la Torre, L. G., 1 May 2024, In: Biotechnology Advances. 72, 108342.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Evolution of the structure of lipid nanoparticles for nucleic acid delivery: From in situ studies of formulation to colloidal stability

    Gilbert, J., Sebastiani, Federica, Arteta, M. Y., Terry, A., Fornell, A., Russell, R., Mahmoudi, N. & Nylander, T., 2024, In: Journal of Colloid and Interface Science. 660, p. 66-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route

    Ongun, Melike, Lokras, Abhijeet, Baghel, Saahil Sandeep, Shi, Zhenning, Schmidt, S. T., Franzyk, Henrik, Rades, Thomas, Sebastiani, Federica, Thakur, A. & Foged, Camilla, 2024, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 198, 10 p., 114266.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies

    Xu, Y., Cañadas, O., Alonso, A., Franzyk, Henrik, Thakur, A., Pérez-gil, J. & Foged, Camilla, 2024, In: Journal of Colloid and Interface Science. 654, Part B, p. 1111-1123

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2023
  8. Published

    Elucidating the nanostructure of small interfering RNA-loaded lipidoid-polymer hybrid nanoparticles

    Aljabbari, Anas Samir Mohammad, Lokras, Abhijeet, Kirkensgaard, Jacob Judas Kain, Rades, Thomas, Franzyk, Henrik, Thakur, A., Zhang, Y. & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 907-922

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Reconstituted Dry Powder Formulations of ZnO-Adjuvanted Ovalbumin Induce Equivalent Serum Antibody Responses to Ovalbumin Adjuvanted with Alhydrogel® or Cationic Adjuvant Formulation 01 (Caf®01)

    Hellfritzsch, M., Christensen, D., Foged, Camilla, Scherließ, R. & Thakur, A., 2023, 41 p. (SSRN Electronic Journal).

    Research output: Working paper › Preprint › Research

  10. Published

    Reconstituted dry powder formulations of ZnO-adjuvanted ovalbumin induce equivalent antigen specific antibodies but lower T cell responses than ovalbumin adjuvanted with Alhydrogel® or cationic adjuvant formulation 01 (CAF®01)

    Hellfritzsch, M., Christensen, D., Foged, Camilla, Scherließ, R. & Thakur, A., 2023, In: International Journal of Pharmaceutics. 648, 15 p., 123581.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Lipid Nanoparticle-Enabled Intracellular Delivery of Prime Editors

    Herrera-Barrera, M., Gautam, M., Lokras, Abhijeet, Vlasova, K., Foged, Camilla & Sahay, G., 2023, In: The AAPS Journal. 25, 4, 10 p., 65.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach

    Maharjan, R., Hada, S., Eun Lee, J., Han, H., Hyun Kim, K., Jin Seo, H., Foged, Camilla & Hoon Jeong, S., 2023, In: International Journal of Pharmaceutics. 640, 13 p., 123012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Pulmonary Administration of the Liposome-Based Adjuvant CAF01: Effect of Surface Charge on Mucosal Adjuvant Function

    Müllertz, O. A. O., Andersen, P., Christensen, D., Foged, Camilla & Thakur, A., 2023, In: Molecular Pharmaceutics. 20, 2, p. 953–970

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Malaria biomimetic for tumor targeted drug delivery

    Pihl, J., Clausen, T. M., Zhou, J., Krishnan, N., Ørum-Madsen, M. S., Gustavsson, Tobias, Dagil, Robert, Daugaard, M., Choudhary, Swati, Foged, Camilla, Esko, J. D., Zhang, L., Fang, R. H. & Salanti, Ali, 2023, In: ACS Nano. 17, 14, p. 13500–13509

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins

    Thakur, A., Wadhwa, A., Lokras, Abhijeet, Amanda Oest Müllertz, O., Christensen, D., Franzyk, Henrik & Foged, Camilla, 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Pulmonary delivery of siRNA-loaded lipid-polymer hybrid nanoparticles: Effect of nanoparticle size

    Wadhwa, A., Bobak, T. R., Bohrmann, L., Geczy, R., Sekar, S., Sathyanarayanan, G., Kutter, Jörg P., Franzyk, Henrik, Foged, Camilla, Saatchi, K. & Häfeli, U. O., 2023, In: OpenNano. 13, 12 p., 100180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant

    Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, Henrik, Pérez-Gil, J., Malmsten, Martin & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Manipulating cell motility by Legionella: Speeding up or slowing down?

    Xu, Y. & Jin, T., 2023, In: Journal of Translational Internal Medicine. 11, 1, p. 24-25

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  19. 2022
  20. Published

    Polysaccharide and monosaccharide guided liver delivery of Sorafenib Tosylate: A nano-strategic approach and comparative assessment of hepatospecificity

    Dhawan, V., Lokras, Abhijeet, Joshi, G., Marwah, M., Venkatraman, M., Mohanty, B., Darshan, K., Chaudhari, P., Warawdekar, U., Saraf, M. & Nagarsenker, M., 2022, In: International Journal of Pharmaceutics. 625, 122039.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    COVID-19: Hvem skal nu vaccineres og hvorfor? Professor giver overblikket: Hvor godt virker vaccinerne? Hvem har især gavn af dem? Og hvad ved vi om bivirkningerne? Professor i vaccinedesign guider dig.

    Foged, Camilla, 16 Sep 2022, In: ForskerZonen. 16.09.2022

    Research output: Contribution to journal › Journal article › Research

  22. Published

    COVID-19: Hvordan sikrer vi, at vores vacciner virker mod de nyeste varianter? Når virus muterer, må vi tilpasse vores vacciner. Hvordan sker det i praksis? Og behøver en vaccine overhovedet være tilpasset den seneste variant for at virke?

    Foged, Camilla, 19 Sep 2022, In: ForskerZonen. 19.09.2022

    Research output: Contribution to journal › Journal article › Communication

  23. Published

    Grand Challenges in Vaccine Delivery: Lessons Learned From the COVID-19 Vaccine Rollout

    Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 4 p., 964298.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    A bifunctional enzyme of Legionella that distinctly regulates phosphoribosyl ubiquitination of the SidE family effectors

    Jiao, J., Ouyang, X., Xu, Y. & Xiong, X., 2022, In: Journal of Translational Internal Medicine. 10, 2, p. 86-88

    Research output: Contribution to journal › Editorial › Research › peer-review

  25. Published

    Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems

    Lokras, Abhijeet, Chakravarty, A., Rades, Thomas, Christensen, D., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Adjuvants, immunomodulators, and adaptogens

    Milicic, A., Reinke, S., Fergusson, J., Lindblad, E. B., Hu, K., Thakur, A., Corby, G., Longet, S., Górska, S., Razim, A., Morein, B., Luchner, M., Christensen, D., Mrenoshki, S., Ceylan, S. E., Gizurarson, S. & Ugwu, M. C., 2022, Vaccinology and Methods in Vaccine Research. Elsevier, p. 223-280

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  27. Published

    Lipid Nanoparticle-Mediated Delivery of Therapeutic and Prophylactic mRNA: Immune Activation by Ionizable Cationic Lipids

    Ongun, Melike, Lokras, Abhijeet, Foged, Camilla & Thakur, A., 2022, Messenger RNA Therapeutics. Springer, p. 237-255 (RNA Technologies, Vol. 13).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  28. Published

    Optimizing the design and dosing of dry powder inhaler formulations of the cationic liposome adjuvant CAF®01 for pulmonary immunization

    Thakur, A., Xu, Y., Cano-Garcia, G., Feng, S., Rose, F., Gerde, P., Andersen, Peter, Christensen, D. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 973599.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability

    Xu, You, Turan, E. T., Shi, Z., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

    Xu, Y., Harinck, L., Lokras, Abhijeet, Gerde, P., Selg, E., Sjöberg, C., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 621, 14 p., 121758.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2021
  32. Published

    Design and evaluation of microemulsion-based efinaconazole formulations for targeted treatment of onychomycosis through transungual route: Ex vivo and nail clipping studies

    Agrawal, V., Patel, R., Patel, M., Thanki, K. & Mishra, S., 2021, In: Colloids and Surfaces B: Biointerfaces. 201, 9 p., 111652.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Polysaccharide conjugates surpass monosaccharide ligands in hepatospecific targeting – Synthesis and comparative in silico and in vitro assessment

    Dhawan, V., Joshi, G., Sutariya, B., Shah, J., Ashtikar, M., Nagarsekar, K., Steiniger, F., Lokras, Abhijeet, Fahr, A., Krishnapriya, M., Warawdekar, U., Saraf, M. & Nagarsenker, M., 2021, In: Carbohydrate Research. 509, 13 p., 108417.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Omikron: Sådan justerer forskerne en mRNA-vaccine

    Foged, Camilla, 3 Dec 2021, In: ForskerZonen. 2021, december

    Research output: Contribution to journal › Journal article › Communication

  35. Published

    Vaccination af børn og unge mod COVID-19: Her er, hvad forskningen viser

    Foged, Camilla, 31 Aug 2021, In: ForskerZonen. 2021, August

    Research output: Contribution to journal › Journal article › Communication

  36. Published

    Delivery of oligonucleotide-based therapeutics: challenges and opportunities

    Hammond, S. M., Aartsma-Rus, A., Alves, S., Borgos, S. E., Buijsen, R. A. M., Collin, R. W. J., Covello, G., Denti, M. A., Desviat, L. R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A. T., Guzowska, M., Holodnuka, I., Jones, D. R., Krause, S., Lehto, T., Montolio, M. & 2 others, Van Roon-Mom, W. & Arechavala-Gomeza, V., 2021, In: EMBO Molecular Medicine. 13, 4, 23 p., e13243.

    Research output: Contribution to journal › Review › Research › peer-review

  37. Published

    Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles Using a Quality-by-Design Approach

    Lokras, Abhijeet, Foged, Camilla & Thakur, A., 2021, Design and Delivery of SiRNA Therapeutics. Ditzel, H. J., Tuttolomondo, M. & Kauppinen, S. (eds.). Humana Press, p. 137-157 (Methods in Molecular Biology, Vol. 2282).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  38. Published

    Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

    Schijns, V., Majhen, D., Van Der Ley, P., Thakur, A., Summerfield, A., Berisio, R., Nativi, C., Fernández-tejada, A., Álverez-dominguez, C., Gizurarson, S., Zamyatina, A., Molinaro, A., Rosano, C., Jakopin, Ž., Gursel, I. & Mcclean, S., 2021, In: Pharmaceutics. 13, 4, 29 p., 501.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Adsorption of protein antigen to the cationic liposome adjuvant CAF®01 is required for induction of Th1 and Th17 responses but not for antibody induction

    Wørzner, K., Hvannastein, J., Tandrup Schmidt, S., Foged, Camilla, Rosenkrands, I., Kristian Pedersen, G. & Christensen, D., 2021, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 165, p. 293-305

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects

    Xu, You, Thakur, A., Zhang, Y. & Foged, Camilla, 2021, In: Pharmaceutics. 13, 2, 35 p., 77.

    Research output: Contribution to journal › Review › Research › peer-review

  41. 2020
  42. Published

    Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

    Bohr, A., Tsapis, N., Foged, Camilla, Andreana, I., Yang, Mingshi & Fattal, E., 2020, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 156, p. 114-120

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

    Frederiksen, L. S. F., Zhang, Y., Foged, Camilla & Thakur, A., 2020, In: Frontiers in Immunology. 11, p. 1817

    Research output: Contribution to journal › Review › Research › peer-review

  44. Published

    Technological Approaches for Improving Vaccination Compliance and Coverage

    Lemoine, C., Thakur, A., Krajišnik, D., Guyon, R., Longet, S., Razim, A., Górska, S., Pantelić, I., Ilić, T., Nikolić, I., Lavelle, E. C., Gamian, A., Savić, S. & Milicic, A., 2020, In: Vaccines. 8, 2, 28 p., 304.

    Research output: Contribution to journal › Review › Research › peer-review

  45. Published

    Epidemiological and clinical characteristics of 2019 novel coronavirus disease (COVID-19) in Jilin, China A descriptive study

    Liu, H., Gao, J., Wang, Y., Jie, J., Luo, J., Xu, Y., Sun, H., Song, L., Li, D., Peng, L. & Hua, S., 2020, In: Medicine. 99, 47, 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

    Lokras, Abhijeet, Thakur, A., Wadhwa, A., Thanki, K., Franzyk, Henrik & Foged, Camilla, 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 601155.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Inflammasome-Mediated Immunogenicity of Clinical and Experimental Vaccine Adjuvants

    Reinke, S., Thakur, A., Gartlan, C., Bezbradica, J. S. & Milicic, A., 2020, In: Vaccines. 8, 3, p. 1-25

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

    Schijns, V., Fernández‐tejada, A., Barjaktarović, Ž., Bouzalas, I., Brimnes, J., Chernysh, S., Gizurarson, S., Gursel, I., Jakopin, Ž., Lawrenz, M., Nativi, C., Paul, S., Pedersen, G. K., Rosano, C., Ruiz‐de‐angulo, A., Slütter, B., Thakur, A., Christensen, D. & Lavelle, E. C., 2020, In: Immunological Reviews. 296, 1, p. 169-190

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

    Thakur, A., Pinto, F. E., Hansen, Harald S., Andersen, Peter, Christensen, D., Janfelt, Christian & Foged, Camilla, 2020, In: Frontiers in Immunology. 11, p. 803

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Woodhead Publishing, p. 603-646 44 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  51. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Mozafari, M. (ed.). 1 ed. Elsevier

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  52. Published

    RP-HPLC method for quantitative estimation of Efinaconazole in topical microemulsion and microemulsion-based-gel formulations and in presence of its degradation products

    Vikas, A., Rashmin, P., Mrunali, P., Sandip, M. & Kaushik, T., 2020, In: Microchemical Journal. 155, 7 p., 104753.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Opportunities and Challenges in the Delivery of mRNA-based Vaccines

    Wadhwa, A., Aljabbari, A., Lokras, Abhijeet, Foged, Camilla & Thakur, A., 28 Jan 2020, In: Pharmaceutics. 12, 2, 27 p., 102.

    Research output: Contribution to journal › Review › Research › peer-review

  54. Published

    Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

    Xu, Y., Liu, H. & Song, L., 2020, In: Journal of Nanobiotechnology. 18, 1, 25 p., 145.

    Research output: Contribution to journal › Review › Research › peer-review

  55. 2019
  56. Published

    Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design

    Borro, B. C., Bohr, A., Bucciarelli, S., Bøtker, Johan Peter, Foged, Camilla, Rantanen, Jukka & Malmsten, Martin, 7 Mar 2019, In: Journal of Colloid and Interface Science. 538, p. 559-568 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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