Vaccine Design and Delivery

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  1. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

    de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation

    Zhang, N., Xu, C., Li, N., Zhang, S., Fu, L., Chu, X., Hua, H., Zeng, X. & Zhao, Y., 23 May 2018, In: Drug Delivery. 25, 1, p. 1182-1191

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

    Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA

    Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

    Research output: Contribution to conference › Conference abstract for conference › Research

  5. Published

    One-pot synthesis and characterization of ovalbumin-conjugated gold nanoparticles: A comparative study of adjuvanticity against the physical mixture of ovalbumin and gold nanoparticles

    Yang, Y., Zhang, Y., Thakur, A., Li, R., Xu, H., Wang, Z., Ghavami, M., Tu, Z. & Liu, H., 25 Nov 2019, In: International Journal of Pharmaceutics. 571, 10 p., 118704.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies

    Xu, Y., Cañadas, O., Alonso, A., Franzyk, Henrik, Thakur, A., Pérez-gil, J. & Foged, Camilla, 2024, In: Journal of Colloid and Interface Science. 654, Part B, p. 1111-1123

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

    Xu, Y., Liu, H. & Song, L., 2020, In: Journal of Nanobiotechnology. 18, 1, 25 p., 145.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Inhalable Composite Microparticles Containing siRNA-Loaded Lipid-Polymer Hybrid Nanoparticles: Saccharides and Leucine Preserve Aerosol Performance and Long-Term Physical Stability

    Xu, You, Turan, E. T., Shi, Z., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 15 p., 945459.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Mechanisms of deformable nanovesicles based on insulin-phospholipid complex for enhancing buccal delivery of insulin

    Xu, You, Zhang, X., Zhang, Y., Ye, J., Wang, H., Xia, X. & Liu, Y., 2018, In: International Journal of Nanomedicine. 13, p. 7319-7331 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Manipulating cell motility by Legionella: Speeding up or slowing down?

    Xu, Y. & Jin, T., 2023, In: Journal of Translational Internal Medicine. 11, 1, p. 24-25

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  11. Published

    Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

    Xu, Y., Harinck, L., Lokras, Abhijeet, Gerde, P., Selg, E., Sjöberg, C., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 621, 14 p., 121758.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Inhaled RNA Therapeutics for Obstructive Airway Diseases: Recent Advances and Future Prospects

    Xu, You, Thakur, A., Zhang, Y. & Foged, Camilla, 2021, In: Pharmaceutics. 13, 2, 35 p., 77.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant

    Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, Henrik, Pérez-Gil, J., Malmsten, Martin & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Adsorption of protein antigen to the cationic liposome adjuvant CAF®01 is required for induction of Th1 and Th17 responses but not for antibody induction

    Wørzner, K., Hvannastein, J., Tandrup Schmidt, S., Foged, Camilla, Rosenkrands, I., Kristian Pedersen, G. & Christensen, D., 2021, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 165, p. 293-305

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

    Wan, F., Larsen, F. H., Nunes Bordallo, Heloisa, Foged, Camilla, Rantanen, Jukka & Yang, Mingshi, 2018, In: A C S Applied Materials and Interfaces. 10, 43, p. 36686-36692

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

    Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    One-Step Production of Protein-Loaded PLGA Microparticles via Spray Drying Using 3-Fluid Nozzle

    Wan, F., Maltesen, M. J., Andersen, S. K., Bjerregaard, S., Foged, Camilla, Rantanen, Jukka & Yang, Mingshi, 19 Feb 2014, In: Pharmaceutical Research. 31, 8, p. 1969-1977 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

    Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Opportunities and Challenges in the Delivery of mRNA-based Vaccines

    Wadhwa, A., Aljabbari, A., Lokras, Abhijeet, Foged, Camilla & Thakur, A., 28 Jan 2020, In: Pharmaceutics. 12, 2, 27 p., 102.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Pulmonary delivery of siRNA-loaded lipid-polymer hybrid nanoparticles: Effect of nanoparticle size

    Wadhwa, A., Bobak, T. R., Bohrmann, L., Geczy, R., Sekar, S., Sathyanarayanan, G., Kutter, Jörg P., Franzyk, Henrik, Foged, Camilla, Saatchi, K. & Häfeli, U. O., 2023, In: OpenNano. 13, 12 p., 100180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    RP-HPLC method for quantitative estimation of Efinaconazole in topical microemulsion and microemulsion-based-gel formulations and in presence of its degradation products

    Vikas, A., Rashmin, P., Mrunali, P., Sandip, M. & Kaushik, T., 2020, In: Microchemical Journal. 155, 7 p., 104753.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells

    Vencken, S., Foged, Camilla, Ramsey, J. M., Sweeney, L., Cryan, S., MacLoughlin, R. J. & Greene, C. M., Apr 2019, In: ERJ Open Research. 5, 2, 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Effects of Aggregate Charge and Subphase Ionic Strength on the Properties of Spread Polyelectrolyte/Surfactant Films at the Air/Water Interface under Static and Dynamic Conditions

    Tummino, A., Toscano, J., Sebastiani, Federica, Noskov, B. A., Varga, I. & Campbell, R. A., 13 Feb 2018, In: Langmuir. 34, 6, p. 2312-2323 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Structural Analysis of Multi-component Amyloid Systems by Chemometric SAXS Data Decomposition

    Trillo, I. F. H., Jensen, M. G., van Maarschalkerweerd, A., Tauler, R., Vestergaard, Bente & Bernadó, P., 3 Jan 2017, In: Structure. 25, 1, p. 5–15 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery

    Thanki, K., Papai, S., Lokras, Abhijeet, Rose, F., Falkenberg, E., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 3, 37.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs

    Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.

    Research output: Contribution to conference › Poster › Research

  27. Published

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

    Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Preparation, Characterization, and In Vitro Evaluation of Lipidoid-Polymer Hybrid Nanoparticles for siRNA Delivery to the Cytosol

    Thanki, K., Zeng, X. & Foged, Camilla, 2019, In: Methods in molecular biology (Clifton, N.J.). 1943, p. 141-152 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities

    Thanki, K., Falkenberg, E., Gangloff, M. & Foged, Camilla, 31 Aug 2018, Immune Effects of Biopharmaceuticals and Nanomedicine. Bawa, R., Szebeni, J. & Audette, G. (eds.). Pan Stanford, 32 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  30. Published

    Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities

    Thanki, K., Blum, K. G., Thakur, A., Rose, F. & Foged, Camilla, Oct 2018, In: Therapeutic Delivery. 9, 10, p. 731-749 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

    Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, Foged, Camilla, 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  32. Published

    Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

    Thakur, A., Ingvarsson, P. T., Schmidt, S. T., Rose, F., Andersen, P., Christensen, D. & Foged, Camilla, 31 May 2018, In: Vaccine. 36, 23, p. 3331-3339 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Woodhead Publishing, p. 603-646 44 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  34. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Mozafari, M. (ed.). 1 ed. Elsevier

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  35. Published

    Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins

    Thakur, A., Wadhwa, A., Lokras, Abhijeet, Amanda Oest Müllertz, O., Christensen, D., Franzyk, Henrik & Foged, Camilla, 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Design of gadoteridol-loaded cationic liposomal adjuvant CAF01 for MRI of lung deposition of intrapulmonary administered particles

    Thakur, A., Rose, F., Ansari, S. R., Koch, P., Martini, V., Ovesen, S. L., Quistorff, B., Maritim, S., Hyder, F., Andersen, Peter, Christensen, D., Mori, Yuki & Foged, Camilla, 2019, In: Molecular Pharmaceutics. 16, 11, p. 4725-4737 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Optimizing the design and dosing of dry powder inhaler formulations of the cationic liposome adjuvant CAF®01 for pulmonary immunization

    Thakur, A., Xu, Y., Cano-Garcia, G., Feng, S., Rose, F., Gerde, P., Andersen, Peter, Christensen, D. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 973599.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies

    Thakur, A., Mikkelsen, H. & Jungersen, G., 2019, In: Journal of Immunology Research. 2019, 24 p., 1356540.

    Research output: Contribution to journal › Review › Research › peer-review

  39. Published

    A study on the prevalence of bovine tuberculosis in farmed dairy cattle in Himachal Pradesh

    Thakur, A., Sharma, M., Katoch, V. C., Dhar, P. & Katoch, R. C., 1 Dec 2010, In: Veterinary World. 3, 9, p. 408-414 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

    Thakur, A., Rodríguez-Rodríguez, C., Saatchi, K., Rose, F., Esposito, T., Nosrati, Z., Andersen, P., Christensen, D., Häfeli, U. O. & Foged, Camilla, 2018, In: Frontiers in Immunology. 9, 21 p., 2825.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

    Thakur, A., Pinto, F. E., Hansen, Harald S., Andersen, Peter, Christensen, D., Janfelt, Christian & Foged, Camilla, 2020, In: Frontiers in Immunology. 11, p. 803

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Bicontinuous cubic liquid crystalline nanoparticles for oral delivery of Doxorubicin: implications on bioavailability, therapeutic efficacy, and cardiotoxicity

    Swarnakar, N. K., Thanki, K. & Jain, S., May 2014, In: Pharmaceutical Research. 31, 5, p. 1219-38 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin

    Swarnakar, N. K., Thanki, K. & Jain, S., Aug 2014, In: Nanomedicine: Nanotechnology, Biology and Medicine. 10, 6, p. 1231-41 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Mixed micellar system stabilized with saponins for oral delivery of vitamin K

    Sun, F., Ye, C., Thanki, K., Leng, D., van Hasselt, P. M., Hennink, W. E. & van Nostrum, C. F., 1 Oct 2018, In: Colloids and Surfaces B: Biointerfaces. 170, p. 521-528 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Simultaneous neutron reflectometry and infrared reflection absorption spectroscopy (IRRAS) study of mixed monolayer reactions at the air-water interface

    Skoda, M. W. A., Thomas, B., Hagreen, M., Sebastiani, Federica & Pfrang, C., 2017, In: RSC Advances.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Complementarity of neutron reflectometry and ellipsometry for the study of atmospheric reactions at the air–water interface

    Sebastiani, Federica, Campbell, R. A. & Pfrang, C., 2015, In: RSC Adv..

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Nighttime oxidation of surfactants at the air–water interface: effects of chain length, head group and saturation

    Sebastiani, Federica, Campbell, R. A., Rastogi, K. & Pfrang, C., 7 Mar 2018, In: Atmospheric Chemistry and Physics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Diffraction studies on natural and model lipid bilayers

    Sebastiani, Federica, Harvey, R., Khanniche, S., Artero, J. B., Haertlein, M. & Fragneto, G., 2012, In: European physical journal-Special topics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

    Schmidt, S. T., Foged, Camilla, Korsholm, K. S., Rades, Thomas & Christensen, D., 10 Mar 2016, In: Pharmaceutics. 8, 1, 22 p., 7.

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile

    Schmidt, S. T., Khadke, S., Korsholm, K. S., Perrie, Y., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 26 Aug 2016, In: Journal of controlled release : official journal of the Controlled Release Society. 239, p. 107-117 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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