Vaccine Design and Delivery

  1. 2018
  2. Published

    Mechanisms of deformable nanovesicles based on insulin-phospholipid complex for enhancing buccal delivery of insulin

    Xu, You, Zhang, X., Zhang, Y., Ye, J., Wang, H., Xia, X. & Liu, Y., 2018, In: International Journal of Nanomedicine. 13, p. 7319-7331 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Potential mucus rheological consequences of off target siRNA loaded nanoparticle deposition in the lungs

    Katuwal, N., Loretz, B., Thanki, K., Hallbrink, M., Lehr, C., Foged, Camilla, Draget, K. & Nordgård, C. T., 2018, ANNUAL TRANSACTIONS OF THE NORDIC RHEOLOGY SOCIETY. Vol. 26.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  4. Published

    Selected contributions from the 10th European Workshop on Particulate Systems, Copenhagen 19th–20th January 2017

    Foged, Camilla, 2018, In: International Journal of Pharmaceutics. 548, 2, p. 729

    Research output: Contribution to journalEditorialResearch

  5. Published

    Temperature-Induced Self-Assembly of the Group B Streptococcus (GBS) Fusion Antigen GBS-NN

    Rose, F., Roovers, S., Fano, M., Rønholt, Stine, Kirkensgaard, Jacob Judas Kain, Hejnaes, K., Fischer, P. & Foged, Camilla, 2018, In: Molecular Pharmaceutics. 15, p. 2584-2593 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522

    Rose, F., Erbo Wern, J., Gavins, F., Andersen, P., Follmann, F. & Foged, Camilla, Feb 2018, In: Journal of Controlled Release. 271, p. 88-97 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Effects of Aggregate Charge and Subphase Ionic Strength on the Properties of Spread Polyelectrolyte/Surfactant Films at the Air/Water Interface under Static and Dynamic Conditions

    Tummino, A., Toscano, J., Sebastiani, Federica, Noskov, B. A., Varga, I. & Campbell, R. A., 13 Feb 2018, In: Langmuir. 34, 6, p. 2312-2323 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

    Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Nighttime oxidation of surfactants at the air–water interface: effects of chain length, head group and saturation

    Sebastiani, Federica, Campbell, R. A., Rastogi, K. & Pfrang, C., 7 Mar 2018, In: Atmospheric Chemistry and Physics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C)

    Schmidt, S. T., Pedersen, G. K., Neustrup, M. A., Korsholm, K. S., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 30 Apr 2018, In: Frontiers in Immunology. 9, 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation

    Zhang, N., Xu, C., Li, N., Zhang, S., Fu, L., Chu, X., Hua, H., Zeng, X. & Zhao, Y., 23 May 2018, In: Drug Delivery. 25, 1, p. 1182-1191

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

    Thakur, A., Ingvarsson, P. T., Schmidt, S. T., Rose, F., Andersen, P., Christensen, D. & Foged, Camilla, 31 May 2018, In: Vaccine. 36, 23, p. 3331-3339 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles

    Rose, F., Karlsen, K., Jensen, P. R., Jakobsen, R. U., Wood, G. K., Rand, Kasper Dyrberg, Godiksen, H., Andersen, P., Follmann, F. & Foged, Camilla, Jun 2018, In: Journal of Pharmaceutical Sciences. 107, 6, p. 1690-1700 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

    de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages

    Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, Mingshi & Nielsen, Hanne Mørck, Aug 2018, In: Journal of Pharmacy and Pharmacology. 70, 8, p. 1009-1021

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities

    Thanki, K., Falkenberg, E., Gangloff, M. & Foged, Camilla, 31 Aug 2018, Immune Effects of Biopharmaceuticals and Nanomedicine. Bawa, R., Szebeni, J. & Audette, G. (eds.). Pan Stanford, 32 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  17. Published

    Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein

    Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, Thomas, Franzyk, Henrik, Pedersen, Anders Elm, Papadakis, C. M., Christensen, D., Winter, G., Foged, Camilla & Hubert, M., 10 Sep 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 285, p. 12-22 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Engineering of budesonide-loaded lipid-polymer hybrid nanoparticles using a quality-by-design approach

    Leng, D., Thanki, K., Fattal, E., Foged, Camilla & Yang, Mingshi, 15 Sep 2018, In: International Journal of Pharmaceutics. 548, 2, p. 740-746

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities

    Thanki, K., Blum, K. G., Thakur, A., Rose, F. & Foged, Camilla, Oct 2018, In: Therapeutic Delivery. 9, 10, p. 731-749 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Mixed micellar system stabilized with saponins for oral delivery of vitamin K

    Sun, F., Ye, C., Thanki, K., Leng, D., van Hasselt, P. M., Hennink, W. E. & van Nostrum, C. F., 1 Oct 2018, In: Colloids and Surfaces B: Biointerfaces. 170, p. 521-528 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Formulating Inhalable Dry Powders Using Two-Fluid and Three-Fluid Nozzle Spray Drying

    Leng, D., Thanki, K., Foged, Camilla & Yang, Mingshi, 1 Nov 2018, In: Pharmaceutical Research. 35, 12, 12 p., 247.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2019
  23. Published

    Application of a Quality-By-Design Approach to Optimise Lipid-Polymer Hybrid Nanoparticles Loaded with a Splice-Correction Antisense Oligonucleotide: Maximising Loading and Intracellular Delivery

    Thanki, K., Papai, S., Lokras, Abhijeet, Rose, F., Falkenberg, E., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 3, 37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design of gadoteridol-loaded cationic liposomal adjuvant CAF01 for MRI of lung deposition of intrapulmonary administered particles

    Thakur, A., Rose, F., Ansari, S. R., Koch, P., Martini, V., Ovesen, S. L., Quistorff, B., Maritim, S., Hyder, F., Andersen, Peter, Christensen, D., Mori, Yuki & Foged, Camilla, 2019, In: Molecular Pharmaceutics. 16, 11, p. 4725-4737 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

    Dormenval, C., Lokras, Abhijeet, Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, Henrik & Foged, Camilla, 2019, In: Pharmaceutical Research. 36, 10, 142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies

    Thakur, A., Mikkelsen, H. & Jungersen, G., 2019, In: Journal of Immunology Research. 2019, 24 p., 1356540.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model

    Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

    Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Preparation, Characterization, and In Vitro Evaluation of Lipidoid-Polymer Hybrid Nanoparticles for siRNA Delivery to the Cytosol

    Thanki, K., Zeng, X. & Foged, Camilla, 2019, In: Methods in molecular biology (Clifton, N.J.). 1943, p. 141-152 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

    Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Design of Inhalable Solid Dosage Forms of Budesonide and Theophylline for Pulmonary Combination Therapy

    Leng, D., Kissi, E. O., Löbmann, Korbinian, Thanki, K., Fattal, E., Rades, Thomas, Foged, Camilla & Yang, Mingshi, 7 Mar 2019, In: AAPS PharmSciTech. 20, 3, 137.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design

    Borro, B. C., Bohr, A., Bucciarelli, S., Bøtker, Johan Peter, Foged, Camilla, Rantanen, Jukka & Malmsten, Martin, 7 Mar 2019, In: Journal of Colloid and Interface Science. 538, p. 559-568 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling

    Hansen, M., Peltier, J., Killy, B., Amin, B., Bodendorfer, B., Härtlova, A., Uebel, S., Bosmann, M., Hofmann, J., Büttner, C., Ekici, A. B., Kuttke, M., Franzyk, Henrik, Foged, Camilla, Beer-Hammer, S., Schabbauer, G., Trost, M. & Lang, R., Apr 2019, In: Molecular and Cellular Proteomics. 18, 4, p. 669-685

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells

    Vencken, S., Foged, Camilla, Ramsey, J. M., Sweeney, L., Cryan, S., MacLoughlin, R. J. & Greene, C. M., Apr 2019, In: ERJ Open Research. 5, 2, 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    One-pot synthesis and characterization of ovalbumin-conjugated gold nanoparticles: A comparative study of adjuvanticity against the physical mixture of ovalbumin and gold nanoparticles

    Yang, Y., Zhang, Y., Thakur, A., Li, R., Xu, H., Wang, Z., Ghavami, M., Tu, Z. & Liu, H., 25 Nov 2019, In: International Journal of Pharmaceutics. 571, 10 p., 118704.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2020
  37. Published

    Epidemiological and clinical characteristics of 2019 novel coronavirus disease (COVID-19) in Jilin, China A descriptive study

    Liu, H., Gao, J., Wang, Y., Jie, J., Luo, J., Xu, Y., Sun, H., Song, L., Li, D., Peng, L. & Hua, S., 2020, In: Medicine. 99, 47, 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Inflammasome-Mediated Immunogenicity of Clinical and Experimental Vaccine Adjuvants

    Reinke, S., Thakur, A., Gartlan, C., Bezbradica, J. S. & Milicic, A., 2020, In: Vaccines. 8, 3, p. 1-25

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published
  40. Published

    Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

    Schijns, V., Fernández‐tejada, A., Barjaktarović, Ž., Bouzalas, I., Brimnes, J., Chernysh, S., Gizurarson, S., Gursel, I., Jakopin, Ž., Lawrenz, M., Nativi, C., Paul, S., Pedersen, G. K., Rosano, C., Ruiz‐de‐angulo, A., Slütter, B., Thakur, A., Christensen, D. & Lavelle, E. C., 2020, In: Immunological Reviews. 296, 1, p. 169-190

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Woodhead Publishing, p. 603-646 44 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  42. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Mozafari, M. (ed.). 1 ed. Elsevier

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  43. Published

    Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

    Xu, Y., Liu, H. & Song, L., 2020, In: Journal of Nanobiotechnology. 18, 1, 25 p., 145.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

    Lokras, Abhijeet, Thakur, A., Wadhwa, A., Thanki, K., Franzyk, Henrik & Foged, Camilla, 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 601155.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    RP-HPLC method for quantitative estimation of Efinaconazole in topical microemulsion and microemulsion-based-gel formulations and in presence of its degradation products

    Vikas, A., Rashmin, P., Mrunali, P., Sandip, M. & Kaushik, T., 2020, In: Microchemical Journal. 155, 7 p., 104753.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Technological Approaches for Improving Vaccination Compliance and Coverage

    Lemoine, C., Thakur, A., Krajišnik, D., Guyon, R., Longet, S., Razim, A., Górska, S., Pantelić, I., Ilić, T., Nikolić, I., Lavelle, E. C., Gamian, A., Savić, S. & Milicic, A., 2020, In: Vaccines. 8, 2, 28 p., 304.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

    Frederiksen, L. S. F., Zhang, Y., Foged, Camilla & Thakur, A., 2020, In: Frontiers in Immunology. 11, p. 1817

    Research output: Contribution to journalReviewResearchpeer-review

  48. Published

    Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

    Bohr, A., Tsapis, N., Foged, Camilla, Andreana, I., Yang, Mingshi & Fattal, E., 2020, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 156, p. 114-120

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Opportunities and Challenges in the Delivery of mRNA-based Vaccines

    Wadhwa, A., Aljabbari, A., Lokras, Abhijeet, Foged, Camilla & Thakur, A., 28 Jan 2020, In: Pharmaceutics. 12, 2, 27 p., 102.

    Research output: Contribution to journalReviewResearchpeer-review

  50. 2021
  51. Published

    Adsorption of protein antigen to the cationic liposome adjuvant CAF®01 is required for induction of Th1 and Th17 responses but not for antibody induction

    Wørzner, K., Hvannastein, J., Tandrup Schmidt, S., Foged, Camilla, Rosenkrands, I., Kristian Pedersen, G. & Christensen, D., 2021, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 165, p. 293-305

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Delivery of oligonucleotide-based therapeutics: challenges and opportunities

    Hammond, S. M., Aartsma-Rus, A., Alves, S., Borgos, S. E., Buijsen, R. A. M., Collin, R. W. J., Covello, G., Denti, M. A., Desviat, L. R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A. T., Guzowska, M., Holodnuka, I., Jones, D. R., Krause, S., Lehto, T., Montolio, M. & 2 others, Van Roon-Mom, W. & Arechavala-Gomeza, V., 2021, In: EMBO Molecular Medicine. 13, 4, 23 p., e13243.

    Research output: Contribution to journalReviewResearchpeer-review

  53. Published

    Design and evaluation of microemulsion-based efinaconazole formulations for targeted treatment of onychomycosis through transungual route: Ex vivo and nail clipping studies

    Agrawal, V., Patel, R., Patel, M., Thanki, K. & Mishra, S., 2021, In: Colloids and Surfaces B: Biointerfaces. 201, 9 p., 111652.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles Using a Quality-by-Design Approach

    Lokras, Abhijeet, Foged, Camilla & Thakur, A., 2021, Design and Delivery of SiRNA Therapeutics. Ditzel, H. J., Tuttolomondo, M. & Kauppinen, S. (eds.). Humana Press, p. 137-157 (Methods in Molecular Biology, Vol. 2282).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review