Vaccine Design and Delivery

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  1. Published

    Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant

    Korsholm, K. S., Hansen, J., Karlsen, K., Filskov, J., Mikkelsen, M., Lindenstrøm, T., Schmidt, S. T., Andersen, P. & Christensen, D., 30 Jun 2014, In: Vaccine. 32, 31, p. 3927-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Technological Approaches for Improving Vaccination Compliance and Coverage

    Lemoine, C., Thakur, A., Krajišnik, D., Guyon, R., Longet, S., Razim, A., Górska, S., Pantelić, I., Ilić, T., Nikolić, I., Lavelle, E. C., Gamian, A., Savić, S. & Milicic, A., 2020, In: Vaccines. 8, 2, 28 p., 304.

    Research output: Contribution to journal › Review › Research › peer-review

  3. Published

    Engineering of budesonide-loaded lipid-polymer hybrid nanoparticles using a quality-by-design approach

    Leng, D., Thanki, K., Fattal, E., Foged, Camilla & Yang, Mingshi, 15 Sep 2018, In: International Journal of Pharmaceutics. 548, 2, p. 740-746

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Formulating Inhalable Dry Powders Using Two-Fluid and Three-Fluid Nozzle Spray Drying

    Leng, D., Thanki, K., Foged, Camilla & Yang, Mingshi, 1 Nov 2018, In: Pharmaceutical Research. 35, 12, 12 p., 247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Design of Inhalable Solid Dosage Forms of Budesonide and Theophylline for Pulmonary Combination Therapy

    Leng, D., Kissi, E. O., Löbmann, Korbinian, Thanki, K., Fattal, E., Rades, Thomas, Foged, Camilla & Yang, Mingshi, 7 Mar 2019, In: AAPS PharmSciTech. 20, 3, 137.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Epidemiological and clinical characteristics of 2019 novel coronavirus disease (COVID-19) in Jilin, China A descriptive study

    Liu, H., Gao, J., Wang, Y., Jie, J., Luo, J., Xu, Y., Sun, H., Song, L., Li, D., Peng, L. & Hua, S., 2020, In: Medicine. 99, 47, 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles Using a Quality-by-Design Approach

    Lokras, Abhijeet, Foged, Camilla & Thakur, A., 2021, Design and Delivery of SiRNA Therapeutics. Ditzel, H. J., Tuttolomondo, M. & Kauppinen, S. (eds.). Humana Press, p. 137-157 (Methods in Molecular Biology, Vol. 2282).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  8. Published

    Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

    Lokras, Abhijeet, Thakur, A., Wadhwa, A., Thanki, K., Franzyk, Henrik & Foged, Camilla, 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 14 p., 601155.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Simultaneous quantification of multiple RNA cargoes co-loaded into nanoparticle-based delivery systems

    Lokras, Abhijeet, Chakravarty, A., Rades, Thomas, Christensen, D., Franzyk, Henrik, Thakur, A. & Foged, Camilla, 2022, In: International Journal of Pharmaceutics. 626, 13 p., 122171.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach

    Maharjan, R., Hada, S., Eun Lee, J., Han, H., Hyun Kim, K., Jin Seo, H., Foged, Camilla & Hoon Jeong, S., 2023, In: International Journal of Pharmaceutics. 640, 13 p., 123012.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Conserved molecular superlattices in a series of homologous synthetic mycobacterial cell-wall lipids forming interdigitated bilayers

    Martin-Bertelsen, Birte, Yaghmur, Anan, Franzyk, Henrik, Justesen, S., Kirkensgaard, Jacob Judas Kain & Foged, Camilla, 7 Nov 2016, In: Langmuir. 32, 48, p. 12693–12701 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: Supramolecular structure and adjuvant efficacy

    Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2016, In: Molecular Pharmaceutics. 13, 8, p. 2771-2781 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The supramolecular structure is decisive for the immunoactivity of a mycobacterial lipid in vitro.

    Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2014. 1 p.

    Research output: Contribution to conference › Poster › Research

  14. Published

    Adjuvants, immunomodulators, and adaptogens

    Milicic, A., Reinke, S., Fergusson, J., Lindblad, E. B., Hu, K., Thakur, A., Corby, G., Longet, S., Górska, S., Razim, A., Morein, B., Luchner, M., Christensen, D., Mrenoshki, S., Ceylan, S. E., Gizurarson, S. & Ugwu, M. C., 2022, Vaccinology and Methods in Vaccine Research. Elsevier, p. 223-280

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15. Published

    Pulmonary Administration of the Liposome-Based Adjuvant CAF01: Effect of Surface Charge on Mucosal Adjuvant Function

    Müllertz, O. A. O., Andersen, P., Christensen, D., Foged, Camilla & Thakur, A., 2023, In: Molecular Pharmaceutics. 20, 2, p. 953–970

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Lipid Nanoparticle-Mediated Delivery of Therapeutic and Prophylactic mRNA: Immune Activation by Ionizable Cationic Lipids

    Ongun, Melike, Lokras, Abhijeet, Foged, Camilla & Thakur, A., 2022, Messenger RNA Therapeutics. Springer, p. 237-255 (RNA Technologies, Vol. 13).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  17. Published

    Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route

    Ongun, Melike, Lokras, Abhijeet, Baghel, Saahil Sandeep, Shi, Zhenning, Schmidt, S. T., Franzyk, Henrik, Rades, Thomas, Sebastiani, Federica, Thakur, A. & Foged, Camilla, 2024, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 198, 10 p., 114266.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Ozonolysis of methyl oleate monolayers at the air-water interface: oxidation kinetics, reaction products and atmospheric implications.

    Pfrang, C., Sebastiani, Federica, Lucas, C., King, M., Hoare, I., Chang, D. & Campbell, R., Jul 2014, In: Phys. Chem. Chem. Phys..

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Malaria biomimetic for tumor targeted drug delivery

    Pihl, J., Clausen, T. M., Zhou, J., Krishnan, N., Ørum-Madsen, M. S., Gustavsson, Tobias, Dagil, Robert, Daugaard, M., Choudhary, Swati, Foged, Camilla, Esko, J. D., Zhang, L., Fang, R. H. & Salanti, Ali, 2023, In: ACS Nano. 17, 14, p. 13500–13509

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages

    Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, Mingshi & Nielsen, Hanne Mørck, Aug 2018, In: Journal of Pharmacy and Pharmacology. 70, 8, p. 1009-1021

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan-poly(ethylene imine) hybrid nanoparticles: A mechanistic insight

    Ragelle, H., Colombo, S., Pourcelle, V., Vanvarenberg, K., Vandermeulen, G., Bouzin, C., Marchand-Brynaert, J., Feron, O., Foged, Camilla & Préat, V., 10 Aug 2015, In: Journal of Controlled Release. 211, p. 1-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Transcutaneous immunization

    Rattanapak, T., Foged, Camilla & Hook, S., 2015, Subunit vaccine delivery. London: Springer, p. 347-369 23 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Inflammasome-Mediated Immunogenicity of Clinical and Experimental Vaccine Adjuvants

    Reinke, S., Thakur, A., Gartlan, C., Bezbradica, J. S. & Milicic, A., 2020, In: Vaccines. 8, 3, p. 1-25

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein

    Rodrigues, L., Raftopoulos, K. N., Tandrup Schmidt, S., Schneider, F., Dietz, H., Rades, Thomas, Franzyk, Henrik, Pedersen, Anders Elm, Papadakis, C. M., Christensen, D., Winter, G., Foged, Camilla & Hubert, M., 10 Sep 2018, In: Journal of controlled release : official journal of the Controlled Release Society. 285, p. 12-22 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach

    Rose, F., Wern, J. E., Ingvarsson, P. T., van de Weert, Marco, Andersen, P., Follmann, F. & Foged, Camilla, 2015, In: Journal of controlled release : official journal of the Controlled Release Society. 210, p. 48-57 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Temperature-Induced Self-Assembly of the Group B Streptococcus (GBS) Fusion Antigen GBS-NN

    Rose, F., Roovers, S., Fano, M., Rønholt, Stine, Kirkensgaard, Jacob Judas Kain, Hejnaes, K., Fischer, P. & Foged, Camilla, 2018, In: Molecular Pharmaceutics. 15, p. 2584-2593 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles

    Rose, F., Karlsen, K., Jensen, P. R., Jakobsen, R. U., Wood, G. K., Rand, Kasper Dyrberg, Godiksen, H., Andersen, P., Follmann, F. & Foged, Camilla, Jun 2018, In: Journal of Pharmaceutical Sciences. 107, 6, p. 1690-1700 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    A strong adjuvant based on glycol-chitosan-coated lipid-polymer hybrid nanoparticles potentiates mucosal immune responses against the recombinant Chlamydia trachomatis fusion antigen CTH522

    Rose, F., Erbo Wern, J., Gavins, F., Andersen, P., Follmann, F. & Foged, Camilla, Feb 2018, In: Journal of Controlled Release. 271, p. 88-97 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation

    Schijns, V., Majhen, D., Van Der Ley, P., Thakur, A., Summerfield, A., Berisio, R., Nativi, C., Fernández-tejada, A., Álverez-dominguez, C., Gizurarson, S., Zamyatina, A., Molinaro, A., Rosano, C., Jakopin, Ž., Gursel, I. & Mcclean, S., 2021, In: Pharmaceutics. 13, 4, 29 p., 501.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

    Schijns, V., Fernández‐tejada, A., Barjaktarović, Ž., Bouzalas, I., Brimnes, J., Chernysh, S., Gizurarson, S., Gursel, I., Jakopin, Ž., Lawrenz, M., Nativi, C., Paul, S., Pedersen, G. K., Rosano, C., Ruiz‐de‐angulo, A., Slütter, B., Thakur, A., Christensen, D. & Lavelle, E. C., 2020, In: Immunological Reviews. 296, 1, p. 169-190

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

    Schmidt, S. T., Foged, Camilla, Korsholm, K. S., Rades, Thomas & Christensen, D., 10 Mar 2016, In: Pharmaceutics. 8, 1, 22 p., 7.

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C)

    Schmidt, S. T., Pedersen, G. K., Neustrup, M. A., Korsholm, K. S., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 30 Apr 2018, In: Frontiers in Immunology. 9, 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile

    Schmidt, S. T., Khadke, S., Korsholm, K. S., Perrie, Y., Rades, Thomas, Andersen, P., Foged, Camilla & Christensen, D., 26 Aug 2016, In: Journal of controlled release : official journal of the Controlled Release Society. 239, p. 107-117 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Diffraction studies on natural and model lipid bilayers

    Sebastiani, Federica, Harvey, R., Khanniche, S., Artero, J. B., Haertlein, M. & Fragneto, G., 2012, In: European physical journal-Special topics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Complementarity of neutron reflectometry and ellipsometry for the study of atmospheric reactions at the air–water interface

    Sebastiani, Federica, Campbell, R. A. & Pfrang, C., 2015, In: RSC Adv..

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Nighttime oxidation of surfactants at the air–water interface: effects of chain length, head group and saturation

    Sebastiani, Federica, Campbell, R. A., Rastogi, K. & Pfrang, C., 7 Mar 2018, In: Atmospheric Chemistry and Physics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Simultaneous neutron reflectometry and infrared reflection absorption spectroscopy (IRRAS) study of mixed monolayer reactions at the air-water interface

    Skoda, M. W. A., Thomas, B., Hagreen, M., Sebastiani, Federica & Pfrang, C., 2017, In: RSC Advances.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Mixed micellar system stabilized with saponins for oral delivery of vitamin K

    Sun, F., Ye, C., Thanki, K., Leng, D., van Hasselt, P. M., Hennink, W. E. & van Nostrum, C. F., 1 Oct 2018, In: Colloids and Surfaces B: Biointerfaces. 170, p. 521-528 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Bicontinuous cubic liquid crystalline nanoparticles for oral delivery of Doxorubicin: implications on bioavailability, therapeutic efficacy, and cardiotoxicity

    Swarnakar, N. K., Thanki, K. & Jain, S., May 2014, In: Pharmaceutical Research. 31, 5, p. 1219-38 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin

    Swarnakar, N. K., Thanki, K. & Jain, S., Aug 2014, In: Nanomedicine: Nanotechnology, Biology and Medicine. 10, 6, p. 1231-41 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Immunological and physical evaluation of the multistage tuberculosis subunit vaccine candidate H56/CAF01 formulated as a spray-dried powder

    Thakur, A., Ingvarsson, P. T., Schmidt, S. T., Rose, F., Andersen, P., Christensen, D. & Foged, Camilla, 31 May 2018, In: Vaccine. 36, 23, p. 3331-3339 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Woodhead Publishing, p. 603-646 44 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  43. Published

    Nanoparticles for mucosal vaccine delivery

    Thakur, A. & Foged, Camilla, 2020, Nanoengineered Biomaterials for Advanced Drug Delivery. Mozafari, M. (ed.). 1 ed. Elsevier

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  44. Published

    Method of manufacturing CAF®09 liposomes affects immune responses induced by adjuvanted subunit proteins

    Thakur, A., Wadhwa, A., Lokras, Abhijeet, Amanda Oest Müllertz, O., Christensen, D., Franzyk, Henrik & Foged, Camilla, 2023, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 189, p. 84-97

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Design of gadoteridol-loaded cationic liposomal adjuvant CAF01 for MRI of lung deposition of intrapulmonary administered particles

    Thakur, A., Rose, F., Ansari, S. R., Koch, P., Martini, V., Ovesen, S. L., Quistorff, B., Maritim, S., Hyder, F., Andersen, Peter, Christensen, D., Mori, Yuki & Foged, Camilla, 2019, In: Molecular Pharmaceutics. 16, 11, p. 4725-4737 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Optimizing the design and dosing of dry powder inhaler formulations of the cationic liposome adjuvant CAF®01 for pulmonary immunization

    Thakur, A., Xu, Y., Cano-Garcia, G., Feng, S., Rose, F., Gerde, P., Andersen, Peter, Christensen, D. & Foged, Camilla, 2022, In: Frontiers in Drug Delivery. 2, 973599.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies

    Thakur, A., Mikkelsen, H. & Jungersen, G., 2019, In: Journal of Immunology Research. 2019, 24 p., 1356540.

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    A study on the prevalence of bovine tuberculosis in farmed dairy cattle in Himachal Pradesh

    Thakur, A., Sharma, M., Katoch, V. C., Dhar, P. & Katoch, R. C., 1 Dec 2010, In: Veterinary World. 3, 9, p. 408-414 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

    Thakur, A., Rodríguez-Rodríguez, C., Saatchi, K., Rose, F., Esposito, T., Nosrati, Z., Andersen, P., Christensen, D., Häfeli, U. O. & Foged, Camilla, 2018, In: Frontiers in Immunology. 9, 21 p., 2825.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

    Thakur, A., Pinto, F. E., Hansen, Harald S., Andersen, Peter, Christensen, D., Janfelt, Christian & Foged, Camilla, 2020, In: Frontiers in Immunology. 11, p. 803

    Research output: Contribution to journal › Journal article › Research › peer-review

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