Toxicology and Drug Metabolism

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  1. 2019
  2. Published

    Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide Α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions

    Kuhlmann, J., Kretschmann, A. C., Bester, K., Bollmann, U. E., Dalhoff, K. & Cedergreen, Nina, 1 Jun 2019, In: Chemosphere. 225, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    State of knowledge on current exposure, fate and potential health effects of contaminants in polar bears from the circumpolar Arctic

    Routti, H., Atwood, T. C., Bechshoft, T., Boltunov, A., Ciesielski, T. M., Desforges, J., Dietz, R., Gabrielsen, G., Jenssen, B. M., Letcher, R. J., McKinney, M. A., Morris, A. D., Riget, F. F., Sonne, C., Styrishave, Bjarne & Tartu, S., 10 May 2019, In: Science of the Total Environment. 664, p. 1063-1083

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

    Handler, A. M., Marxen, E., Jacobsen, Jette & Janfelt, Christian, 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, Christian, Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, Anders, Chalmel, F., Jégou, B. & Skakkebæk, Niels Erik, 2019, In: Scientific Reports. 9, 1, 14 p., 12866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Developing a predictive in vitro dissolution model based on gastrointestinal fluid characterisation in rats

    Christfort, J. F., Strindberg, S., Plum, J., Hall-Andersen, J., Janfelt, Christian, Nielsen, L. H. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 307-314 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

    Bohr, A., Nascimento, T. L., Harmankaya, N., Weisser, J. J., Wang, Y., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 2019, In: Molecules. 24, 2, 13 p., 266.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax

    Munkboel, C. H., Rasmussen, T. B., Elgaard, C., Olesen, M. L. K., Kretschmann, A. C. & Styrishave, Bjarne, 2019, In: Toxicology. 425, 152247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Three versus five days of pivmecillinam for community-acquired uncomplicated lower urinary tract infection: A randomised, double-blind, placebo-controlled superiority trial

    Jansåker, F., Thønnings, S., Hertz, F. B., Kallemose, T., Værnet, J., Bjerrum, Lars, Benfield, Thomas, Frimodt-Møller, N. & Knudsen, J. D., 2019, In: EClinicalMedicine. 12, p. 62-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. 2018
  11. Published

    Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

    Castberg, F. C., Sarbah, E. W., Koram, K. A., Opoku, N., Ofori, M. F., Styrishave, Bjarne, Hviid, Lars & Kurtzhals, Jørgen, 11 Dec 2018, In: Malaria Journal. 17, 1, 464.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

    Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, Harald S. & Janfelt, Christian, 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

    Hansen, S. E., Marxen, E., Janfelt, Christian & Jacobsen, Jette, Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Occurrence, removal and risk assessment of steroid hormones in two wastewater stabilization pond systems in Morogoro, Tanzania

    Damkjaer, K., Weisser, J. J., Msigala, S. C., Mdegela, R. & Styrishave, Bjarne, Dec 2018, In: Chemosphere. 212, p. 1142-1154

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro

    Munkboel, C. H., Christensen, L. R., Islin, J., Bonomo, S., Olsen, L., Jørgensen, Flemming Steen & Styrishave, Bjarne, Oct 2018, In: Biology of Reproduction. 99, 4, p. 888-897

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  17. Published

    Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism

    Munkboel, C. H., Larsen, L. W., Weisser, J. J., Kristensen, D. M. & Styrishave, Bjarne, Jun 2018, In: Toxicological Sciences. 163, 2, p. 609-619

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Occurrence and risk assessment of antibiotics in water and lettuce in Ghana

    Azanu, D., Styrishave, Bjarne, Darko, G., Weisser, J. J. & Abaidoo, R. C., 1 May 2018, In: Science of the Total Environment. 622-23, p. 293-305

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats

    Munkboel, C. H., Baake, M. L. K. & Styrishave, Bjarne, May 2018, In: Archives of Toxicology. 92, 5, p. 1703-1715

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3 beta-HSD inhibition

    Munkboel, C. H., Hasselstrom, S. B., Kristensen, D. M. & Styrishave, Bjarne, Apr 2018, In: Toxicology in Vitro. 48, p. 302-309

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Assessment of the analgesic dipyrone as a possible (anti) androgenic endocrine disruptor

    Passoni, M. T., Kristensen, M. N., Morais, R. N., Woitkowiak, C., Boareto, A. C., da Silva Amaral, B. A., Grechi, N., Dalsenter, P. R., Munkboel, C. H., Styrishave, Bjarne, Kristensen, D. M., Gomes, C., van Ravenzwaay, B. & Martino-Andrade, A. J., 15 Mar 2018, In: Toxicology Letters. 285, p. 139-147

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

    Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, Christian, Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Steroidogenic disruptive effects of the serotonin-noradrenaline reuptake inhibitors duloxetine, venlafaxine and tramadol in the H295R cell assay and in a recombinant CYP17 assay

    Islin, J., Munkboel, C. H. & Styrishave, Bjarne, Mar 2018, In: Toxicology in Vitro. 47, p. 63-71

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

    Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

    Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham.) K. Schum Leaves Analysed by Desorption Electrospray Ionisation Mass Spectrometry Imaging

    Kato, L., Moraes, A. P., de Oliveira, C. M. A., Vaz, B. G., de Almeida Gonçalves, L., E Silva, E. C. & Janfelt, Christian, 2018, In: Phytochemical Analysis. 29, p. 69-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

    Gallage, N. J., Jørgensen, Kirsten, Janfelt, Christian, Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. & Møller, Birger Lindberg, 2018, In: Plant and Cell Physiology. 59, 2, p. 304-318 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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