Toxicology and Drug Metabolism

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  1. Published

    Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

    Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

    Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Comparison of global DNA methylation analysis by whole genome bisulfite sequencing and the Infinium Mouse Methylation BeadChip using fresh and fresh-frozen mouse epidermis

    Meyer, Olivia Luxford, Andersen, M. M., Børsting, Claus, Morling, Niels, Wulf, H. C., Philipsen, P. A., Lerche, Catharina Margrethe & Andersen, Jeppe Dyrberg, 2023, In: Epigenetics. 18, 1, 10 p., 2144574 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination

    Montini, L., Crocoll, C., Gleadow, R. M., Motawia, M. S., Janfelt, Christian & Bjarnholt, Nanna, 2020, In: Plant Physiology. 183, 3, p. 925-942 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

    Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, Harald S. & Janfelt, Christian, 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    LC-MS/MS Method for Determination of Non-opioid Analgesics Adulterants in Herbal Medicines

    Mpanyakavili, A. L., Mwankuna, C. J., Mabiki, F. P. & Styrishave, Bjarne, 2022, In: Chemistry Africa. 5, p. 2149–2162

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro

    Munkboel, C. H., Christensen, L. R., Islin, J., Bonomo, S., Olsen, L., Jørgensen, Flemming Steen & Styrishave, Bjarne, Oct 2018, In: Biology of Reproduction. 99, 4, p. 888-897

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism

    Munkboel, C. H., Larsen, L. W., Weisser, J. J., Kristensen, D. M. & Styrishave, Bjarne, Jun 2018, In: Toxicological Sciences. 163, 2, p. 609-619

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats

    Munkboel, C. H., Baake, M. L. K. & Styrishave, Bjarne, May 2018, In: Archives of Toxicology. 92, 5, p. 1703-1715

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax

    Munkboel, C. H., Rasmussen, T. B., Elgaard, C., Olesen, M. L. K., Kretschmann, A. C. & Styrishave, Bjarne, 2019, In: Toxicology. 425, 152247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3 beta-HSD inhibition

    Munkboel, C. H., Hasselstrom, S. B., Kristensen, D. M. & Styrishave, Bjarne, Apr 2018, In: Toxicology in Vitro. 48, p. 302-309

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Oral anti-diabetic drugs as endocrine disruptors in vitro - No evidence for additive effects in binary mixtures

    Munkboel, C. H., Hansen, H. S., Jessen, J. B., Johannsen, Malene Louise & Styrishave, Bjarne, 2021, In: Toxicology in Vitro. 70, 12 p., 105007.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Optimization of HPLC–MS/MS method for determination of antimalarial adulterants in herbal products

    Mwankuna, C. J., Kiros, F., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Mdegela, R. H. & Styrishave, Bjarne, 2023, In: Analytical Sciences. 39, p. 407-416

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Thin Layer Chromatographic Method for Detection of Conventional Drug Adulterants in Herbal Products

    Mwankuna, C. J., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Styrishave, Bjarne & Mdegela, R. H., 2023, In: Separations. 10, 1, 10 p., 23.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A HPLC-MS/MS method for screening of selected antibiotic adulterants in herbal drugs

    Mwankuna, C. J., Uwamaliya, G. A., Mariki, E. E., Mabiki, F., Malebo, H. M., Mdegela, R. & Styrishave, Bjarne, 2022, In: Analytical Methods. 14, 10, p. 1060-1068

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Mixture Effects of 3 Mechanistically Different Steroidogenic Disruptors (Prochloraz, Genistein, and Ketoconazole) in the H295R Cell Assay

    Nielsen, F. K., Hansen, C. H., Fey, J. A., Hansen, M., Halling-Sørensen, B., Björklund, E. & Styrishave, Bjarne, Nov 2015, In: International Journal of Toxicology. 34, 6, p. 534-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, Christian, Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, Anders, Chalmel, F., Jégou, B. & Skakkebæk, Niels Erik, 2019, In: Scientific Reports. 9, 1, 14 p., 12866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology

    Olesen, U. H., Jacobsen, K., Lerche, Catharina Margrethe & Hædersdal, Merete, 2023, In: Lasers in Surgery and Medicine. 55, 1, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Anti-pd-1 therapy with adjuvant ablative fractional laser improves anti-tumor response in basal cell carcinomas

    Olesen, U. H., Wiinberg, M., Lerche, Catharina Margrethe, Jæhger, D. E., Andresen, T. L. & Hædersdal, Merete, 2021, In: Cancers. 13, 24, 14 p., 6326.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

    Otterbach, S. L., Yang, T., Kato, L., Janfelt, Christian & Geu-Flores, Fernando, 15 Oct 2019, In: Journal of Experimental Botany. 70, 20, p. 5799-5808

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  23. Published

    Assessment of the analgesic dipyrone as a possible (anti) androgenic endocrine disruptor

    Passoni, M. T., Kristensen, M. N., Morais, R. N., Woitkowiak, C., Boareto, A. C., da Silva Amaral, B. A., Grechi, N., Dalsenter, P. R., Munkboel, C. H., Styrishave, Bjarne, Kristensen, D. M., Gomes, C., van Ravenzwaay, B. & Martino-Andrade, A. J., 15 Mar 2018, In: Toxicology Letters. 285, p. 139-147

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Ablative fractional laser treatment reduces hedgehog pathway gene expression in murine basal cell carcinomas

    Pedersen, K. K., Granborg, J. R., Lerche, Catharina Margrethe, Litman, Thomas, Olesen, U. H. & Hædersdal, Merete, 2024, In: Lasers in Medical Science. 39, 1, 9 p., 55.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice

    Pihl, Celina, Granborg, J. R., Pinto, F. E., Bjerring, P., Andersen, F., Janfelt, Christian, Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, In: Phytomedicine Plus. 4, 2, 8 p., 100547.

    Research output: Contribution to journal › Journal article › Research › peer-review

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