Toxicology and Drug Metabolism

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  1. Published

    Few X-ray and PUVA treatments accelerate photocarcinogenesis in hairless mice

    Lerche, Catharina Margrethe, Al-Chaer, R. N., Glud, M., Philipsen, P. A. & Wulf, H. C., 2021, In: Photochemical and Photobiological Sciences. 20, 10, p. 1299-1307

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Follicular fluid steroid hormones and in vitro embryo development in Duroc and Landrace pigs

    Jochems, R., Gaustad, A. H., Styrishave, Bjarne, Zak, L. J., Oskam, I. C., Grindflek, E., Myromslien, F. D., Kommisrud, E. & Krogenæs, A. K., 2022, In: Theriogenology. 190, p. 15-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

    Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, Christian, Hansen, S. H., Hædersdal, Merete & Lerche, C. M., Dec 2019, In: Drug Delivery. 26, 1, p. 244-251 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    High Oral Vitamin D3 Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice

    Lerche, Catharina Margrethe, Pinto, F. E., Philipsen, P. A., Bech, E. S., Jakobsen, J., Hædersdal, Merete & Wulf, H. C., 2022, In: Anticancer Research. 42, 10, p. 5083-5090

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    High oral vitamin D intake does not protect against UVR-induced squamous cell carcinoma in hairless mice

    Lerche, Catharina Margrethe, Pinto, F. E., Philipsen, P. A., Bech, E., Jakobsen, J., Hædersdal, Merete & Wulf, H. C., 2022, In: Anticancer Research. 42, 4, p. 2205-2205

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  6. Published

    High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer

    Li, Y., Ling Ma, N., Chen, H., Zhong, J., Zhang, D., Peng, W., Shiung Lam, S., Yang, Y., Yue, X., Yan, L., Wang, T., Styrishave, Bjarne, Maciej Ciesielski, T. & Sonne, C., 2023, In: Environment International. 181, 10 p., 108279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Importance of Dietary Uptake for in Situ Bioaccumulation of Systemic Fungicides Using Gammarus pulex as a Model Organism

    Raths, J., Schnurr, J., Bundschuh, M., Pinto, F. E., Janfelt, Christian & Hollender, J., 2023, In: Environmental Toxicology and Chemistry. 42, 9, p. 1993-2006

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry

    Bik, L., van Doorn, M., Hansen, Anders Christian Nørgaard, Janfelt, Christian, Olesen, U. H., Hædersdal, Merete, Lerche, Catharina Margrethe & Hendel, K., 2022, In: Expert Opinion on Drug Delivery. 19, 2, p. 213-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

    Thakur, A., Pinto, F. E., Hansen, Harald S., Andersen, Peter, Christensen, D., Janfelt, Christian & Foged, Camilla, 2020, In: Frontiers in Immunology. 11, p. 803

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Is the unique benzodiazepine structure interacting with CYP enzymes to affect steroid synthesis in vitro?

    Johannsen, Malene Louise, Munkboel, C. H., Jørgensen, Flemming Steen & Styrishave, Bjarne, 2021, In: Journal of Steroid Biochemistry and Molecular Biology. 205, 10 p., 105765.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Isolation and elucidation of antibacterial compounds from roots and stems of Synadenium glaucescens Pax

    Rwegoshora, F., Msengwa, Z., Mabiki, F., Machumi, F., Chacha, M., Styrishave, Bjarne & Cornett, Claus, 2023, In: East African Journal of Science, Technology and Innovation. 4, 2, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax

    Rwegoshora, F., Mabiki, F., Machumi, F., Chacha, M., Styrishave, Bjarne & Cornett, Claus, 2022, In: The Journal of Phytopharmacology. 11, 5, p. 347-352

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins

    Pihl, Celina, Togsverd-Bo, K., Andersen, F., Hædersdal, Merete, Bjerring, P. & Lerche, Catharina Margrethe, 2021, In: Cancers. 13, 15, 29 p., 3684.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    LC-MS/MS Method for Determination of Non-opioid Analgesics Adulterants in Herbal Medicines

    Mpanyakavili, A. L., Mwankuna, C. J., Mabiki, F. P. & Styrishave, Bjarne, 2022, In: Chemistry Africa. 5, p. 2149–2162

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids

    Lorensen, Marcus Daniel B B, Hayat, S. Y., Wellner, N., Bjarnholt, Nanna & Janfelt, Christian, 2023, In: Phytochemical Analysis. 34, 3, p. 269-279

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

    Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, Christian, Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients

    Handler, A. M., Fallah, M., Just Pedersen, A., Pommergaard Pedersen, G., Troensegaard Nielsen, K. & Janfelt, Christian, 2020, In: International Journal of Pharmaceutics. 590, 119949.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

    Castberg, F. C., Sarbah, E. W., Koram, K. A., Opoku, N., Ofori, M. F., Styrishave, Bjarne, Hviid, Lars & Kurtzhals, Jørgen, 11 Dec 2018, In: Malaria Journal. 17, 1, 464.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Mass spectrometry imaging in drug distribution and drug metabolism studies: Principles, applications and perspectives

    Granborg, J. R., Handler, A. M. & Janfelt, Christian, 2022, In: Trends in Analytical Chemistry. 146, 13 p., 116482.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Mass spectrometry imaging of oligosaccharides following in situ enzymatic treatment of maize kernels

    Granborg, J. R., Kaasgaard, S. G. & Janfelt, Christian, 2022, In: Carbohydrate Polymers. 275, 10 p., 118693.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination

    Montini, L., Crocoll, C., Gleadow, R. M., Motawia, M. S., Janfelt, Christian & Bjarnholt, Nanna, 2020, In: Plant Physiology. 183, 3, p. 925-942 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Measuring and validating concentrations of steroid hormones in the skin of bottlenose dolphins (Tursiops truncatus)

    Bechshoft, T., Wright, A. J., Styrishave, Bjarne & Houser, D., 2020, In: Conservation Physiology. 8, 1, 13 p., 032.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

    Mallia, V., Verhaegen, S., Styrishave, Bjarne, Eriksen, G. S., Johannsen, Malene Louise, Ropstad, E. & Uhlig, S., 2020, In: PLoS ONE. 15, 12, 18 p., 0244000.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Mixture Effects of 3 Mechanistically Different Steroidogenic Disruptors (Prochloraz, Genistein, and Ketoconazole) in the H295R Cell Assay

    Nielsen, F. K., Hansen, C. H., Fey, J. A., Hansen, M., Halling-Sørensen, B., Björklund, E. & Styrishave, Bjarne, Nov 2015, In: International Journal of Toxicology. 34, 6, p. 534-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production

    Wardman, Jonathan Henry, Jensen, Mette Nyholm, Andreassen, Søren Norge, Styrishave, Bjarne, Wilhjelm, J. E., Sinclair, A. J. & MacAulay, Nanna, 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 44.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

    Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, Mai Bay, Nielsen, Hanne Mørck, Janfelt, Christian, Hatton, P. V. & Jacobsen, Jette, Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

    Stie, Mai Bay, Öblom, H., Hansen, Anders Christian Nørgaard, Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Nicotinamide and phytochemicals phloroglucinol and syringic acid delay uvr-induced squamous cell carcinoma onset in hairless mice

    Pihl, Celina, Andersen, F., Bjerring, P., Hædersdal, Merete & Lerche, Catharina Margrethe, 2022, In: Anticancer Research. 42, 4, p. 2207-2207

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. Published

    Non-aqueous electrophoresis integrated with electrospray ionization mass spectrometry on a thiol-ene polymer-based microchip device

    Lu, N., Petersen, Nickolaj J., Kretschmann, A. C. & Kutter, Jörg P., 2021, In: Analytical and Bioanalytical Chemistry. 413, p. 4195–4205

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Occurrence and risk assessment of antibiotics in water and lettuce in Ghana

    Azanu, D., Styrishave, Bjarne, Darko, G., Weisser, J. J. & Abaidoo, R. C., 1 May 2018, In: Science of the Total Environment. 622-23, p. 293-305

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Occurrence, removal and risk assessment of steroid hormones in two wastewater stabilization pond systems in Morogoro, Tanzania

    Damkjaer, K., Weisser, J. J., Msigala, S. C., Mdegela, R. & Styrishave, Bjarne, Dec 2018, In: Chemosphere. 212, p. 1142-1154

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Optimization of HPLC–MS/MS method for determination of antimalarial adulterants in herbal products

    Mwankuna, C. J., Kiros, F., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Mdegela, R. H. & Styrishave, Bjarne, 2023, In: Analytical Sciences. 39, p. 407-416

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Accepted/In press

    Oral Squamous Cell Carcinoma Lipid Evaluation in Gingiva Tissue Stored in TRIzol via Shotgun Lipidomics and MALDI Mass Spectrometry Imaging

    Bernardo, R. A., de Oliveira Júnior, C. I., Roque, J. V., Costa, N. D. L., Roriz, V. M., Sorgi, C. A., Janfelt, Christian, Vaz, B. G. & Chaves, A. R., 2023, (Accepted/In press) In: Journal of Proteome Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice

    Pihl, Celina, Granborg, J. R., Pinto, F. E., Bjerring, P., Andersen, F., Janfelt, Christian, Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, In: Phytomedicine Plus. 4, 2, 8 p., 100547.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Oral anti-diabetic drugs as endocrine disruptors in vitro - No evidence for additive effects in binary mixtures

    Munkboel, C. H., Hansen, H. S., Jessen, J. B., Johannsen, Malene Louise & Styrishave, Bjarne, 2021, In: Toxicology in Vitro. 70, 12 p., 105007.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Oral intake of bucillamine, carvedilol, metformin, or phenformin does not protect against UVR-induced squamous cell carcinomas in hairless mice

    Pihl, Celina, Bjerring, P., Andersen, F., Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, In: Photochemical and Photobiological Sciences. 23, p. 517-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Oral phytochemicals as photoprotectants in UVR exposed hairless mice: A study of hesperidin methyl chalcone, phloroglucinol, and syringic acid

    Pihl, Celina, Bendtsen, K. M. S., Jensen, Henrik Elvang, Andersen, F., Bjerring, P., Hædersdal, Merete & Lerche, Catharina Margrethe, 2023, In: Journal of Photochemistry and Photobiology B: Biology. 246, 112760.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

    Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Phototesting in erythropoietic protoporphyria trials: A systematic review

    Heerfordt, I. M., Philipsen, P. A., Lerche, Catharina Margrethe & Wulf, H. C., 2023, In: Experimental Dermatology. 32, 7, p. 1042-1047

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    Protection against visible light by dihydroxyacetone in erythropoietic protoporphyria

    Heerfordt, I. M., Philipsen, P. A., Lerche, Catharina Margrethe & Wulf, H. C., 2023, In: Photodiagnosis and Photodynamic Therapy. 41, 5 p., 103302.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Quantification of Urinary Thymidine Dimers in Volunteers After Ultraviolet Radiation Using a New UPLC-MS/MS-based Method

    Lerche, Catharina Margrethe, Philipsen, P. A., Hermansson, S., Heydenreich, J. & Wulf, H. C., 2022, In: Anticancer Research. 42, 10, p. 5069-5076

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Quantifying urinary thymine dimers based on LC-MS/MS

    Lerche, Catharina Margrethe, Philipsen, P. A., Hermansson, S., Heydenreich, J. & Wulf, H. C., 2022, In: Anticancer Research. 42, 4, p. 2204-2204 22.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  44. Published

    Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin

    Handler, A. M., Pedersen, G. P., Nielsen, K. T., Janfelt, Christian, Pedersen, A. J. & Clench, M. R., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 159, p. 1-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Quantitative Mass Spectrometry Imaging of Bleomycin in Skin Using a Mimetic Tissue Model for Calibration

    Traberg, A., Pinto, F. E., Hansen, Anders Christian Nørgaard, Hædersdal, Merete, Lerche, Catharina Margrethe & Janfelt, Christian, 2022, In: Pharmaceuticals. 15, 12, 15 p., 1583.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

    Otterbach, S. L., Yang, T., Kato, L., Janfelt, Christian & Geu-Flores, Fernando, 15 Oct 2019, In: Journal of Experimental Botany. 70, 20, p. 5799-5808

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology

    Olesen, U. H., Jacobsen, K., Lerche, Catharina Margrethe & Hædersdal, Merete, 2023, In: Lasers in Surgery and Medicine. 55, 1, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Reservoir of Antibiotic Residues and Resistant Coagulase Negative Staphylococci in a Healthy Population in the Greater Accra Region, Ghana

    Bekoe, S. O., Hane-Weijman, S., Trads, S. L., Orman, E., Opintan, J., Hansen, M., Frimodt-Møller, N. & Styrishave, Bjarne, 2022, In: Antibiotics. 11, 1, 12 p., 119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism

    Munkboel, C. H., Larsen, L. W., Weisser, J. J., Kristensen, D. M. & Styrishave, Bjarne, Jun 2018, In: Toxicological Sciences. 163, 2, p. 609-619

    Research output: Contribution to journal › Journal article › Research › peer-review

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