Toxicology and Drug Metabolism

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  1. Published

    Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

    Strindberg, S., Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

    Handler, A. M., Marxen, E., Jacobsen, Jette & Janfelt, Christian, 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Visualization of penetration of topical antifungal drug substances through mycosis-infected nails by matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI)

    Joly-Tonetti, N., Pinto, F. E., Bagger, C., Osman-Ponchet, H. & Janfelt, Christian, 2021, In: Journal of the American Academy of Dermatology. 85, 3, p. AB191-AB191 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  4. Published

    Visualisation of penetration of topical antifungal drug substances through mycosis-infected nails by matrix-assisted laser desorption ionisation mass spectrometry imaging

    Endringer Pinto, F., Bagger, C., Kunze, G., Joly-Tonetti, N., Thenot, J., Osman-Ponchet, H. & Janfelt, Christian, 2020, In: Mycoses. 63, 8, p. 869-875 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Variation in oligosaccharide profiles observed with AP-MALDI in different regions of maize kernels after treatment with xylanases

    Granborg, J. R., Kaasgaard, S. G. & Janfelt, Christian, 2023, In: Journal of Cereal Science. 109, 10 p., 103586.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Accepted/In press

    Urinary thymidine dimer excretion reflects personal ultraviolet radiation exposure levels

    Lerche, Catharina Margrethe, Frederiksen, N. J. S., Thorsteinsson, I. S., Køster, B., Nybo, Lars, Flouris, A. D., Heydenreich, J., Philipsen, P. A., Hædersdal, Merete, Wulf, H. C. & Granborg, J. R., 2024, (Accepted/In press) In: Photochemical and Photobiological Sciences.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Tumor Clearance and Immune Cell Recruitment in UV-Induced Murine Squamous Cell Carcinoma Exposed to Ablative Fractional Laser and Imiquimod Treatment

    Fontenete, S., Lerche, Catharina Margrethe, Paasch, U., Perez-Moreno, Mirna, Olesen, U. H. & Hædersdal, Merete, 2021, In: Lasers in Surgery and Medicine. 53, 9, p. 1227-1237 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Towards a microfluidic H295R steroidogenesis assay—biocompatibility study and steroid detection on a thiol-ene-based chip

    Despicht, C., Munkboel, C. H., Chou, H. N., Ertl, P., Rothbauer, M., Kutter, Jörg P., Styrishave, Bjarne & Kretschmann, A., 2023, In: Analytical and Bioanalytical Chemistry. 415, p. 5421–5436

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Topical Brimonidine Delays Ultraviolet Radiation-Induced Squamous Cell Carcinoma in Hairless Mice

    Pinto, F. E., Olsen, P., Glud, M., Wulf, H. C. & Lerche, Catharina Margrethe, 2022, In: Photochemistry and Photobiology. 98, 6, p. 1390-1394

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Tissue-specific stilbene accumulation is an early response to wounding/grafting as revealed by using spatial and temporal metabolomics

    Loupit, G., Fonayet, J. V., Lorensen, Marcus Daniel B B, Franc, C., De Revel, G., Janfelt, Christian & Cookson, S. J., 2023, In: Plant Cell and Environment. 46, 12, p. 3871-3886

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Tissue distribution and metabolic profiling of cyclosporine (CsA) in mouse and rat investigated by DESI and MALDI mass spectrometry imaging (MSI) of whole-body and single organ cryo-sections

    Holm, N. B., Deryabina, M., Knudsen, C. B. & Janfelt, Christian, 2022, In: Analytical and Bioanalytical Chemistry. 414, p. 7167–7177

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Three versus five days of pivmecillinam for community-acquired uncomplicated lower urinary tract infection: A randomised, double-blind, placebo-controlled superiority trial

    Jansåker, F., Thønnings, S., Hertz, F. B., Kallemose, T., Værnet, J., Bjerrum, Lars, Benfield, Thomas, Frimodt-Møller, N. & Knudsen, J. D., 2019, In: EClinicalMedicine. 12, p. 62-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Thin Layer Chromatographic Method for Detection of Conventional Drug Adulterants in Herbal Products

    Mwankuna, C. J., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Styrishave, Bjarne & Mdegela, R. H., 2023, In: Separations. 10, 1, 10 p., 23.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis

    Fonnes, S., Weisser, J. J., Holzknecht, Barbara Juliane, Arpi, M. & Rosenberg, Jacob, 2020, In: Fundamental and Clinical Pharmacology. 34, 4, p. 504-512 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture

    Johannsen, Malene Louise, Poulsen, L. C., Mamsen, L. S., Grøndahl, M. L., Englund, A. L. M., Lauritsen, N. L., Carstensen, E. C., Styrishave, Bjarne & tcg964, tcg964, 2024, In: Human Reproduction. 39, 3, p. 578-585

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

    Gallage, N. J., Jørgensen, Kirsten, Janfelt, Christian, Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. & Møller, Birger Lindberg, 2018, In: Plant and Cell Physiology. 59, 2, p. 304-318 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  18. Published

    The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax

    Munkboel, C. H., Rasmussen, T. B., Elgaard, C., Olesen, M. L. K., Kretschmann, A. C. & Styrishave, Bjarne, 2019, In: Toxicology. 425, 152247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro

    Munkboel, C. H., Christensen, L. R., Islin, J., Bonomo, S., Olsen, L., Jørgensen, Flemming Steen & Styrishave, Bjarne, Oct 2018, In: Biology of Reproduction. 99, 4, p. 888-897

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The aerial epidermis is a major site of quinolizidine alkaloid biosynthesis in narrow-leafed lupin

    Frick, Karen Michiko, Lorensen, Marcus Daniel B B, Esteban, E., Pasha, A., Schulz, Alexander, Provart, N. J., Janfelt, Christian, Nour-Eldin, Hussam Hassan & Geu-Flores, Fernando, 2023, bioRxiv, 18 p.

    Research output: Working paper › Preprint › Research

  21. Published

    The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham.) K. Schum Leaves Analysed by Desorption Electrospray Ionisation Mass Spectrometry Imaging

    Kato, L., Moraes, A. P., de Oliveira, C. M. A., Vaz, B. G., de Almeida Gonçalves, L., E Silva, E. C. & Janfelt, Christian, 2018, In: Phytochemical Analysis. 29, p. 69-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

    Stander, E. A., Lehka, B., Carqueijeiro, I., Cuello, C., Hansson, F. G., Jansen, H. J., Dugé De Bernonville, T., Birer Williams, C., Vergès, V., Lezin, E., Lorensen, M. D. B. B., Dang, T. T., Oudin, A., Lanoue, A., Durand, M., Giglioli-Guivarc’h, N., Janfelt, C., Papon, N., Dirks, R. P., O’connor, S. E. & 3 others, Jensen, M. K., Besseau, S. & Courdavault, V., 2023, In: Communications Biology . 6, 1, 19 p., 1197.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The Acute and Chronic Effects of Acetazolamide and Topiramate on Intracranial Pressure and CSF Secretion

    Westgate, C., Kamp-Jensen, C., Israelsen, I., Toft-Bertelsen, Trine Lisberg, Wardman, Jonathan Henry, Jensen, C., Styrishave, Bjarne, MacAulay, Nanna, Jensen, Rasmus Herlo Beenfeldt & Eftekhari, S., 2022, In: Journal of Headache and Pain. 23, Suppl. 1, 1 p., P218.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  24. Published

    Testosterone and persistent organic pollutants in East Greenland male polar bears (Ursus maritimus)

    Ciesielski, T. M., Sonne, C., Smette, E. I., Villanger, G. D., Styrishave, Bjarne, Letcher, R. J., Hitchcock, D. J., Dietz, R. & Jenssen, B. M., 2023, In: Heliyon. 9, 3, 10 p., e13263.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Steroidogenic disruptive effects of the serotonin-noradrenaline reuptake inhibitors duloxetine, venlafaxine and tramadol in the H295R cell assay and in a recombinant CYP17 assay

    Islin, J., Munkboel, C. H. & Styrishave, Bjarne, Mar 2018, In: Toxicology in Vitro. 47, p. 63-71

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    State of knowledge on current exposure, fate and potential health effects of contaminants in polar bears from the circumpolar Arctic

    Routti, H., Atwood, T. C., Bechshoft, T., Boltunov, A., Ciesielski, T. M., Desforges, J., Dietz, R., Gabrielsen, G., Jenssen, B. M., Letcher, R. J., McKinney, M. A., Morris, A. D., Riget, F. F., Sonne, C., Styrishave, Bjarne & Tartu, S., 10 May 2019, In: Science of the Total Environment. 664, p. 1063-1083

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging

    Lorensen, Marcus Daniel B B, Bjarnholt, Nanna, St-Pierre, B., Heinicke, S., Courdavault, V., O'Connor, S. & Janfelt, Christian, 2023, In: Phytochemistry. 209, 15 p., 113620.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models

    Christensen, S. L., Rasmussen, Rikke Holm, Cour, S. L., Ernstsen, C., Hansen, Thomas Folkmann, Kogelman, L. J. A., Lauritzen, S. P., Guzaite, G., Styrishave, Bjarne, Janfelt, Christian, Christensen, Søren Tvorup, Aziz, Q., Tinker, A., Jansen-Olesen, I., Olesen, Jes & Kristensen, D. M., 2022, In: Cephalalgia. 42, 2, p. 93-107

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Sled Dogs as Sentinel Species for Monitoring Arctic Ecosystem Health

    Sonne, C., Letcher, R. J., Jenssen, B. M., Desforges, J., Eulaers, I., Andersen-Ranberg, E., Gustavson, K., Bossi, R., Styrishave, Bjarne, Sinding, Mikkel Holger Strander & Dietz, R., 2020, Pets as Sentinels, Forecasters and Promoters of Human Health. Pastorinho, M. R. & Sousa, A. C. A. (eds.). Springer, p. 21-45 25 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  30. Published

    Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism

    Munkboel, C. H., Larsen, L. W., Weisser, J. J., Kristensen, D. M. & Styrishave, Bjarne, Jun 2018, In: Toxicological Sciences. 163, 2, p. 609-619

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Reservoir of Antibiotic Residues and Resistant Coagulase Negative Staphylococci in a Healthy Population in the Greater Accra Region, Ghana

    Bekoe, S. O., Hane-Weijman, S., Trads, S. L., Orman, E., Opintan, J., Hansen, M., Frimodt-Møller, N. & Styrishave, Bjarne, 2022, In: Antibiotics. 11, 1, 12 p., 119.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology

    Olesen, U. H., Jacobsen, K., Lerche, Catharina Margrethe & Hædersdal, Merete, 2023, In: Lasers in Surgery and Medicine. 55, 1, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

    Otterbach, S. L., Yang, T., Kato, L., Janfelt, Christian & Geu-Flores, Fernando, 15 Oct 2019, In: Journal of Experimental Botany. 70, 20, p. 5799-5808

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Quantitative Mass Spectrometry Imaging of Bleomycin in Skin Using a Mimetic Tissue Model for Calibration

    Traberg, A., Pinto, F. E., Hansen, Anders Christian Nørgaard, Hædersdal, Merete, Lerche, Catharina Margrethe & Janfelt, Christian, 2022, In: Pharmaceuticals. 15, 12, 15 p., 1583.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin

    Handler, A. M., Pedersen, G. P., Nielsen, K. T., Janfelt, Christian, Pedersen, A. J. & Clench, M. R., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 159, p. 1-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Quantifying urinary thymine dimers based on LC-MS/MS

    Lerche, Catharina Margrethe, Philipsen, P. A., Hermansson, S., Heydenreich, J. & Wulf, H. C., 2022, In: Anticancer Research. 42, 4, p. 2204-2204 22.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  38. Published

    Quantification of Urinary Thymidine Dimers in Volunteers After Ultraviolet Radiation Using a New UPLC-MS/MS-based Method

    Lerche, Catharina Margrethe, Philipsen, P. A., Hermansson, S., Heydenreich, J. & Wulf, H. C., 2022, In: Anticancer Research. 42, 10, p. 5069-5076

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Protection against visible light by dihydroxyacetone in erythropoietic protoporphyria

    Heerfordt, I. M., Philipsen, P. A., Lerche, Catharina Margrethe & Wulf, H. C., 2023, In: Photodiagnosis and Photodynamic Therapy. 41, 5 p., 103302.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Phototesting in erythropoietic protoporphyria trials: A systematic review

    Heerfordt, I. M., Philipsen, P. A., Lerche, Catharina Margrethe & Wulf, H. C., 2023, In: Experimental Dermatology. 32, 7, p. 1042-1047

    Research output: Contribution to journal › Review › Research › peer-review

  41. Published

    Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

    Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Oral phytochemicals as photoprotectants in UVR exposed hairless mice: A study of hesperidin methyl chalcone, phloroglucinol, and syringic acid

    Pihl, Celina, Bendtsen, K. M. S., Jensen, Henrik Elvang, Andersen, F., Bjerring, P., Hædersdal, Merete & Lerche, Catharina Margrethe, 2023, In: Journal of Photochemistry and Photobiology B: Biology. 246, 112760.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Oral intake of bucillamine, carvedilol, metformin, or phenformin does not protect against UVR-induced squamous cell carcinomas in hairless mice

    Pihl, Celina, Bjerring, P., Andersen, F., Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, In: Photochemical and Photobiological Sciences. 23, p. 517-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Oral anti-diabetic drugs as endocrine disruptors in vitro - No evidence for additive effects in binary mixtures

    Munkboel, C. H., Hansen, H. S., Jessen, J. B., Johannsen, Malene Louise & Styrishave, Bjarne, 2021, In: Toxicology in Vitro. 70, 12 p., 105007.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Oral administration of quercetin and fisetin potentiates photocarcinogenesis in UVR-exposed hairless mice

    Pihl, Celina, Granborg, J. R., Pinto, F. E., Bjerring, P., Andersen, F., Janfelt, Christian, Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, In: Phytomedicine Plus. 4, 2, 8 p., 100547.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Accepted/In press

    Oral Squamous Cell Carcinoma Lipid Evaluation in Gingiva Tissue Stored in TRIzol via Shotgun Lipidomics and MALDI Mass Spectrometry Imaging

    Bernardo, R. A., de Oliveira Júnior, C. I., Roque, J. V., Costa, N. D. L., Roriz, V. M., Sorgi, C. A., Janfelt, Christian, Vaz, B. G. & Chaves, A. R., 2023, (Accepted/In press) In: Journal of Proteome Research.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Optimization of HPLC–MS/MS method for determination of antimalarial adulterants in herbal products

    Mwankuna, C. J., Kiros, F., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Mdegela, R. H. & Styrishave, Bjarne, 2023, In: Analytical Sciences. 39, p. 407-416

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Occurrence, removal and risk assessment of steroid hormones in two wastewater stabilization pond systems in Morogoro, Tanzania

    Damkjaer, K., Weisser, J. J., Msigala, S. C., Mdegela, R. & Styrishave, Bjarne, Dec 2018, In: Chemosphere. 212, p. 1142-1154

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Occurrence and risk assessment of antibiotics in water and lettuce in Ghana

    Azanu, D., Styrishave, Bjarne, Darko, G., Weisser, J. J. & Abaidoo, R. C., 1 May 2018, In: Science of the Total Environment. 622-23, p. 293-305

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Non-aqueous electrophoresis integrated with electrospray ionization mass spectrometry on a thiol-ene polymer-based microchip device

    Lu, N., Petersen, Nickolaj J., Kretschmann, A. C. & Kutter, Jörg P., 2021, In: Analytical and Bioanalytical Chemistry. 413, p. 4195–4205

    Research output: Contribution to journal › Journal article › Research › peer-review

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