Toxicology and Drug Metabolism

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  1. Published

    The aerial epidermis is a major site of quinolizidine alkaloid biosynthesis in narrow-leafed lupin

    Frick, Karen Michiko, Lorensen, Marcus Daniel B B, Esteban, E., Pasha, A., Schulz, Alexander, Provart, N. J., Janfelt, Christian, Nour-Eldin, Hussam Hassan & Geu-Flores, Fernando, 2023, bioRxiv, 18 p.

    Research output: Working paper › Preprint › Research

  2. Published

    Effects of empagliflozin on erythropoiesis in heart failure: data from the Empire HF trial

    Fuchs Andersen, C., Omar, M., Glenthøj, Andreas Birkedal, Fassi, Daniel El , Møller, H. J., Kurtzhals, Jørgen, Styrishave, Bjarne, Kistorp, Caroline Michaela Nervil, Tuxen, C., Poulsen, M. K., Faber, Jens, Køber, Lars Valeur, Gustafsson, Finn, Møller, J. E., Schou, Morten & Jensen, J., 2023, In: European Journal of Heart Failure. 25, 2, p. 226-234

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia

    Gallage, N. J., Jørgensen, Kirsten, Janfelt, Christian, Nielsen, A. J. Z., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. & Møller, Birger Lindberg, 2018, In: Plant and Cell Physiology. 59, 2, p. 304-318 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Mass spectrometry imaging of oligosaccharides following in situ enzymatic treatment of maize kernels

    Granborg, J. R., Kaasgaard, S. G. & Janfelt, Christian, 2022, In: Carbohydrate Polymers. 275, 10 p., 118693.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Variation in oligosaccharide profiles observed with AP-MALDI in different regions of maize kernels after treatment with xylanases

    Granborg, J. R., Kaasgaard, S. G. & Janfelt, Christian, 2023, In: Journal of Cereal Science. 109, 10 p., 103586.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Mass spectrometry imaging in drug distribution and drug metabolism studies: Principles, applications and perspectives

    Granborg, J. R., Handler, A. M. & Janfelt, Christian, 2022, In: Trends in Analytical Chemistry. 146, 13 p., 116482.

    Research output: Contribution to journal › Review › Research › peer-review

  7. Published

    A randomized, placebo-controlled, trial to assess the photosensitizing, phototoxic and carcinogenic potential of hydrochlorothiazide in healthy volunteers

    Götzinger, F., Hohl, M., Lauder, L., Millenaar, D., Kunz, M., Meyer, M. R., Ukena, C., Lerche, Catharina Margrethe, Philipsen, P. A., Reichrath, J., Böhm, M. & Mahfoud, F., 2023, In: Journal of Hypertension. 41, 11, p. 1853-1862

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

    Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, Christian, Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients

    Handler, A. M., Fallah, M., Just Pedersen, A., Pommergaard Pedersen, G., Troensegaard Nielsen, K. & Janfelt, Christian, 2020, In: International Journal of Pharmaceutics. 590, 119949.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Quantitative MALDI mass spectrometry imaging for exploring cutaneous drug delivery of tofacitinib in human skin

    Handler, A. M., Pedersen, G. P., Nielsen, K. T., Janfelt, Christian, Pedersen, A. J. & Clench, M. R., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 159, p. 1-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

    Handler, A. M., Marxen, E., Jacobsen, Jette & Janfelt, Christian, 15 Jan 2019, In: European Journal of Pharmaceutical Sciences. 127, p. 276-281 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging

    Handler, A. M., Eirefelt, S., Lambert, M., Johansson, F., Hollesen Schefe, L., Knudsen, N. Ø., Bodenlenz, M., Birngruber, T., Sinner, F., Eriksson, A. H., Pedersen, G. P., Janfelt, Christian & Troensegaard Nielsen, K., 2021, In: Molecular Pharmaceutics. 18, 8, p. 3063-3072

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Baseline Hepcidin Does Not Predict the Response to Iron Therapy in Pregnant Women with Iron Deficiency

    Hansen, R., Kurtzhals, Jørgen, Styrishave, Bjarne & Bischof, Charlotte Holm, 2021, In: Blood. 138, Suppl 1, 3076.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  14. Published

    Buccal delivery of small molecules - Impact of levulinic acid, oleic acid, sodium dodecyl sulfate and hypotonicity on ex vivo permeability and spatial distribution in mucosa

    Hansen, S. E., Marxen, E., Janfelt, Christian & Jacobsen, Jette, Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 250-257

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review

    Heerfordt, I. M., Lerche, Catharina Margrethe, Philipsen, P. A. & Wulf, H. C., 2023, In: Biomedicine and Pharmacotherapy. 158, 11 p., 114132.

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Detection of cutaneous malignant melanoma using RNA sampled by tape strips: A study protocol

    Heerfordt, I. M., Andersen, Jeppe Dyrberg, Philipsen, P. A., Langhans, L., Tvedebrink, Torben, Schmidt, G., Poulsen, T., Lerche, Catharina Margrethe, Morling, Niels & Wulf, H. C., 2022, In: PLoS ONE. 17, 9 , 11 p., e0274413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Distribution of protoporphyrin IX in erythrocytes in a case of acquired erythropoietic protoporphyria

    Heerfordt, I. M., Fontenete, S., Lerche, Catharina Margrethe & Wulf, H. C., 2022, In: Photodiagnosis and Photodynamic Therapy. 37, 3 p., 102629.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Protection against visible light by dihydroxyacetone in erythropoietic protoporphyria

    Heerfordt, I. M., Philipsen, P. A., Lerche, Catharina Margrethe & Wulf, H. C., 2023, In: Photodiagnosis and Photodynamic Therapy. 41, 5 p., 103302.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Cimetidine for erythropoietic protoporphyria

    Heerfordt, I. M., Lerche, Catharina Margrethe & Wulf, H. C., 2022, In: Photodiagnosis and Photodynamic Therapy. 38, 5 p., 102793.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Phototesting in erythropoietic protoporphyria trials: A systematic review

    Heerfordt, I. M., Philipsen, P. A., Lerche, Catharina Margrethe & Wulf, H. C., 2023, In: Experimental Dermatology. 32, 7, p. 1042-1047

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: in vivo investigations with mass spectrometry imaging

    Hendel, K., Hansen, Anders Christian Nørgaard, Bik, L., Bagger, C., van Doorn, M. B. A., Janfelt, Christian, Olesen, U. H., Hædersdal, Merete & Lerche, Catharina Margrethe, 1 Jan 2021, In: Drug Delivery. 28, 1, p. 1141-1149 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

    Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, Christian, Hansen, S. H., Hædersdal, Merete & Lerche, C. M., Dec 2019, In: Drug Delivery. 26, 1, p. 244-251 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    FK506-Binding Protein 2 Participates in Proinsulin Folding

    Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, Borowiak, M., Wierer, M., MacDonald, P. E., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2023, In: Biomolecules. 13, 1, 20 p., 152.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Tissue distribution and metabolic profiling of cyclosporine (CsA) in mouse and rat investigated by DESI and MALDI mass spectrometry imaging (MSI) of whole-body and single organ cryo-sections

    Holm, N. B., Deryabina, M., Knudsen, C. B. & Janfelt, Christian, 2022, In: Analytical and Bioanalytical Chemistry. 414, p. 7167–7177

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Steroidogenic disruptive effects of the serotonin-noradrenaline reuptake inhibitors duloxetine, venlafaxine and tramadol in the H295R cell assay and in a recombinant CYP17 assay

    Islin, J., Munkboel, C. H. & Styrishave, Bjarne, Mar 2018, In: Toxicology in Vitro. 47, p. 63-71

    Research output: Contribution to journal › Journal article › Research › peer-review

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