Toxicology and Drug Metabolism

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  1. Published

    Nicotinamide and phytochemicals phloroglucinol and syringic acid delay uvr-induced squamous cell carcinoma onset in hairless mice

    Pihl, Celina, Andersen, F., Bjerring, P., Hædersdal, Merete & Lerche, Catharina Margrethe, 2022, In: Anticancer Research. 42, 4, p. 2207-2207

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  2. Published

    Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

    Stie, Mai Bay, Öblom, H., Hansen, A. C. N., Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

    Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, Mai Bay, Nielsen, Hanne Mørck, Janfelt, Christian, Hatton, P. V. & Jacobsen, Jette, Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production

    Wardman, Jonathan Henry, Jensen, Mette Nyholm, Andreassen, Søren Norge, Styrishave, Bjarne, Wilhjelm, J. E., Sinclair, A. J. & MacAulay, Nanna, 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 44.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Mixture Effects of 3 Mechanistically Different Steroidogenic Disruptors (Prochloraz, Genistein, and Ketoconazole) in the H295R Cell Assay

    Nielsen, F. K., Hansen, C. H., Fey, J. A., Hansen, M., Halling-Sørensen, B., Björklund, E. & Styrishave, Bjarne, Nov 2015, In: International Journal of Toxicology. 34, 6, p. 534-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

    Mallia, V., Verhaegen, S., Styrishave, Bjarne, Eriksen, G. S., Johannsen, Malene Louise, Ropstad, E. & Uhlig, S., 2020, In: PLoS ONE. 15, 12, 18 p., 0244000.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Measuring and validating concentrations of steroid hormones in the skin of bottlenose dolphins (Tursiops truncatus)

    Bechshoft, T., Wright, A. J., Styrishave, Bjarne & Houser, D., 2020, In: Conservation Physiology. 8, 1, 13 p., 032.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination

    Montini, L., Crocoll, C., Gleadow, R. M., Motawia, M. S., Janfelt, Christian & Bjarnholt, Nanna, 2020, In: Plant Physiology. 183, 3, p. 925-942 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Mass spectrometry imaging of oligosaccharides following in situ enzymatic treatment of maize kernels

    Granborg, J. R., Kaasgaard, S. G. & Janfelt, Christian, 2022, In: Carbohydrate Polymers. 275, 10 p., 118693.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Mass spectrometry imaging in drug distribution and drug metabolism studies: Principles, applications and perspectives

    Granborg, J. R., Handler, A. M. & Janfelt, Christian, 2022, In: Trends in Analytical Chemistry. 146, 13 p., 116482.

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

    Castberg, F. C., Sarbah, E. W., Koram, K. A., Opoku, N., Ofori, M. F., Styrishave, Bjarne, Hviid, Lars & Kurtzhals, Jørgen, 11 Dec 2018, In: Malaria Journal. 17, 1, 464.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients

    Handler, A. M., Fallah, M., Just Pedersen, A., Pommergaard Pedersen, G., Troensegaard Nielsen, K. & Janfelt, Christian, 2020, In: International Journal of Pharmaceutics. 590, 119949.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    MALDI imaging of enzymatic degradation of glycerides by lipase on textile surface

    Hall-Andersen, J., Kaasgaard, S. G. & Janfelt, Christian, Mar 2018, In: Chemistry and Physics of Lipids. 211, p. 100-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids

    Lorensen, Marcus Daniel B B, Hayat, S. Y., Wellner, N., Bjarnholt, Nanna & Janfelt, Christian, 2023, In: Phytochemical Analysis. 34, 3, p. 269-279

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    LC-MS/MS Method for Determination of Non-opioid Analgesics Adulterants in Herbal Medicines

    Mpanyakavili, A. L., Mwankuna, C. J., Mabiki, F. P. & Styrishave, Bjarne, 2022, In: Chemistry Africa. 5, p. 2149–2162

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins

    Pihl, Celina, Togsverd-Bo, K., Andersen, F., Hædersdal, Merete, Bjerring, P. & Lerche, Catharina Margrethe, 2021, In: Cancers. 13, 15, 29 p., 3684.

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax

    Rwegoshora, F., Mabiki, F., Machumi, F., Chacha, M., Styrishave, Bjarne & Cornett, Claus, 2022, In: The Journal of Phytopharmacology. 11, 5, p. 347-352

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Isolation and elucidation of antibacterial compounds from roots and stems of Synadenium glaucescens Pax

    Rwegoshora, F., Msengwa, Z., Mabiki, F., Machumi, F., Chacha, M., Styrishave, Bjarne & Cornett, Claus, 2023, In: East African Journal of Science, Technology and Innovation. 4, 2, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Is the unique benzodiazepine structure interacting with CYP enzymes to affect steroid synthesis in vitro?

    Johannsen, Malene Louise, Munkboel, C. H., Jørgensen, Flemming Steen & Styrishave, Bjarne, 2021, In: Journal of Steroid Biochemistry and Molecular Biology. 205, 10 p., 105765.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

    Thakur, A., Pinto, F. E., Hansen, Harald S., Andersen, Peter, Christensen, D., Janfelt, Christian & Foged, Camilla, 2020, In: Frontiers in Immunology. 11, p. 803

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry

    Bik, L., van Doorn, M., Hansen, A. C. N., Janfelt, Christian, Olesen, U. H., Hædersdal, Merete, Lerche, Catharina Margrethe & Hendel, K., 2022, In: Expert Opinion on Drug Delivery. 19, 2, p. 213-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Importance of Dietary Uptake for in Situ Bioaccumulation of Systemic Fungicides Using Gammarus pulex as a Model Organism

    Raths, J., Schnurr, J., Bundschuh, M., Pinto, F. E., Janfelt, Christian & Hollender, J., 2023, In: Environmental Toxicology and Chemistry. 42, 9, p. 1993-2006

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer

    Li, Y., Ling Ma, N., Chen, H., Zhong, J., Zhang, D., Peng, W., Shiung Lam, S., Yang, Y., Yue, X., Yan, L., Wang, T., Styrishave, Bjarne, Maciej Ciesielski, T. & Sonne, C., 2023, In: Environment International. 181, 10 p., 108279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    High oral vitamin D intake does not protect against UVR-induced squamous cell carcinoma in hairless mice

    Lerche, Catharina Margrethe, Pinto, F. E., Philipsen, P. A., Bech, E., Jakobsen, J., Hædersdal, Merete & Wulf, H. C., 2022, In: Anticancer Research. 42, 4, p. 2205-2205

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  26. Published

    High Oral Vitamin D3 Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice

    Lerche, Catharina Margrethe, Pinto, F. E., Philipsen, P. A., Bech, E. S., Jakobsen, J., Hædersdal, Merete & Wulf, H. C., 2022, In: Anticancer Research. 42, 10, p. 5083-5090

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

    Hendel, K. K., Bagger, C., Olesen, U. H., Janfelt, Christian, Hansen, S. H., Hædersdal, Merete & Lerche, C. M., Dec 2019, In: Drug Delivery. 26, 1, p. 244-251 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Follicular fluid steroid hormones and in vitro embryo development in Duroc and Landrace pigs

    Jochems, R., Gaustad, A. H., Styrishave, Bjarne, Zak, L. J., Oskam, I. C., Grindflek, E., Myromslien, F. D., Kommisrud, E. & Krogenæs, A. K., 2022, In: Theriogenology. 190, p. 15-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Few X-ray and PUVA treatments accelerate photocarcinogenesis in hairless mice

    Lerche, Catharina Margrethe, Al-Chaer, R. N., Glud, M., Philipsen, P. A. & Wulf, H. C., 2021, In: Photochemical and Photobiological Sciences. 20, 10, p. 1299-1307

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    FK506-Binding Protein 2 Participates in Proinsulin Folding

    Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, Borowiak, M., Wierer, M., MacDonald, P. E., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2023, In: Biomolecules. 13, 1, 20 p., 152.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus

    Kamp-Jensen, Christina, Donslund, L. N., Styrishave, Bjarne, Jensen, Rigmor Højland & Westgate, C. S. J., 2024, In: Toxicology and Applied Pharmacology. 486, 11 p., 116919.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Exposure of consumers to substandard antibiotics from selected authorised and unauthorised medicine sales outlets in Ghana

    Bekoe, S. O., Ahiabu, M. A., Orman, E., Tersbøl, Britt Pinkowski, Adosraku, R. K., Hansen, M., Frimodt-Møller, N. & Styrishave, Bjarne, 2020, In: Tropical Medicine and International Health. 25, 8, p. 962-975 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review

    Heerfordt, I. M., Lerche, Catharina Margrethe, Philipsen, P. A. & Wulf, H. C., 2023, In: Biomedicine and Pharmacotherapy. 158, 11 p., 114132.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide Α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions

    Kuhlmann, J., Kretschmann, A. C., Bester, K., Bollmann, U. E., Dalhoff, K. & Cedergreen, Nina, 1 Jun 2019, In: Chemosphere. 225, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Elucidating the spatial distribution of organic contaminants and their biotransformation products in amphipod tissue by MALDI- and DESI-MS-imaging

    Raths, J., Pinto, F. E., Janfelt, Christian & Hollender, J., 2023, In: Ecotoxicology and Environmental Safety. 264, 10 p., 115468.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

    Kalouta, Kleopatra, Stie, Mai Bay, Janfelt, Christian, Chronakis, I. S., Jacobsen, Jette, Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

    Bohr, A., Nascimento, T. L., Harmankaya, N., Weisser, J. J., Wang, Y., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 2019, In: Molecules. 24, 2, 13 p., 266.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. E-pub ahead of print

    Efficacy of combinational treatment versus nicotinamide monotherapy in the prevention of ultraviolet radiation-induced skin cancer

    Pihl, Celina, Andersen, F., Bjerring, P., Hædersdal, Merete & Lerche, Catharina Margrethe, 2024, (E-pub ahead of print) In: Dermatology. 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma

    Wenande, E., Hendel, K., Mogensen, Mette, Bagger, C., Mårtensson, Nina Løth, Persson, Daniel Pergament, Lerche, C. M., Husted, Søren, Janfelt, Christian, Togsverd‐bo, K., Anderson, R. R. & Hædersdal, Merete, 2021, In: Lasers in Surgery and Medicine. 53, 1, p. 119-128 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Effects of iron supplements in individuals with erythropoietic protoporphyria

    Heerfordt, I. M., Lerche, Catharina Margrethe, Philipsen, P. A. & Wulf, H. C., 2024, In: Photodiagnosis and Photodynamic Therapy. 47, 5 p., 104211.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Effects of empagliflozin on erythropoiesis in heart failure: data from the Empire HF trial

    Fuchs Andersen, C., Omar, M., Glenthøj, Andreas Birkedal, Fassi, Daniel El , Møller, H. J., Kurtzhals, Jørgen, Styrishave, Bjarne, Kistorp, Caroline Michaela Nervil, Tuxen, C., Poulsen, M. K., Faber, Jens, Køber, Lars Valeur, Gustafsson, Finn, Møller, J. E., Schou, Morten & Jensen, J., 2023, In: European Journal of Heart Failure. 25, 2, p. 226-234

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3 beta-HSD inhibition

    Munkboel, C. H., Hasselstrom, S. B., Kristensen, D. M. & Styrishave, Bjarne, Apr 2018, In: Toxicology in Vitro. 48, p. 302-309

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

    Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?

    Lerche, Catharina Margrethe, Al-Chaer, R. N. & Wulf, H. C., 2023, In: Experimental Dermatology. 32, 4, p. 341-347

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Distribution of protoporphyrin IX in erythrocytes in a case of acquired erythropoietic protoporphyria

    Heerfordt, I. M., Fontenete, S., Lerche, Catharina Margrethe & Wulf, H. C., 2022, In: Photodiagnosis and Photodynamic Therapy. 37, 3 p., 102629.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Developing a predictive in vitro dissolution model based on gastrointestinal fluid characterisation in rats

    Christfort, J. F., Strindberg, S., Plum, J., Hall-Andersen, J., Janfelt, Christian, Nielsen, L. H. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 307-314 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Detection of cutaneous malignant melanoma using RNA sampled by tape strips: A study protocol

    Heerfordt, I. M., Andersen, Jeppe Dyrberg, Philipsen, P. A., Langhans, L., Tvedebrink, Torben, Schmidt, G., Poulsen, T., Lerche, Catharina Margrethe, Morling, Niels & Wulf, H. C., 2022, In: PLoS ONE. 17, 9 , 11 p., e0274413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Detection and quantification of antibiotic residues in urine samples of healthy individuals from rural and urban communities in Ghana using a validated SPE-LC-MS/MS method

    Bekoe, S. O., Orman, E., Asare-Nkansah, S., Sorensen, A. M. L., Bjorklund, E., Adosraku, R. K., Hansen, M. & Styrishave, Bjarne, 2020, In: SN Applied Sciences. 2, 11, 11 p., 1903.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography

    Jacobsen, S. C., Speth, N. R., Xiong, M., Herth, Matthias Manfred, Kristensen, Jesper Langgaard, Palner, M. & Janfelt, Christian, 2021, In: Molecular Imaging and Biology. 23, p. 676–685

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

    Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, Harald S. & Janfelt, Christian, 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

    Research output: Contribution to journal › Journal article › Research › peer-review

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