Toxicology and Drug Metabolism

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  1. Published

    Tissue distribution and metabolic profiling of cyclosporine (CsA) in mouse and rat investigated by DESI and MALDI mass spectrometry imaging (MSI) of whole-body and single organ cryo-sections

    Holm, N. B., Deryabina, M., Knudsen, C. B. & Janfelt, Christian, 2022, In: Analytical and Bioanalytical Chemistry. 414, p. 7167–7177

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Steroidogenic disruptive effects of the serotonin-noradrenaline reuptake inhibitors duloxetine, venlafaxine and tramadol in the H295R cell assay and in a recombinant CYP17 assay

    Islin, J., Munkboel, C. H. & Styrishave, Bjarne, Mar 2018, In: Toxicology in Vitro. 47, p. 63-71

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Cycle-dependent sex differences in expression of membrane proteins involved in cerebrospinal fluid secretion at rat choroid plexus

    Israelsen, I. M. E., Kamp-Jensen, C., Westgate, C. S. J., Styrishave, Bjarne, Jensen, Rigmor Højland & Eftekhari, S., 2023, In: BMC Neuroscience. 24, 1, 11 p., 60.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography

    Jacobsen, S. C., Speth, N. R., Xiong, M., Herth, Matthias Manfred, Kristensen, Jesper Langgaard, Palner, M. & Janfelt, Christian, 2021, In: Molecular Imaging and Biology. 23, p. 676–685

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Three versus five days of pivmecillinam for community-acquired uncomplicated lower urinary tract infection: A randomised, double-blind, placebo-controlled superiority trial

    Jansåker, F., Thønnings, S., Hertz, F. B., Kallemose, T., Værnet, J., Bjerrum, Lars, Benfield, Thomas, Frimodt-Møller, N. & Knudsen, J. D., 2019, In: EClinicalMedicine. 12, p. 62-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Follicular fluid steroid hormones and in vitro embryo development in Duroc and Landrace pigs

    Jochems, R., Gaustad, A. H., Styrishave, Bjarne, Zak, L. J., Oskam, I. C., Grindflek, E., Myromslien, F. D., Kommisrud, E. & Krogenæs, A. K., 2022, In: Theriogenology. 190, p. 15-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    The intrafollicular concentrations of biologically active cortisol in women rise abruptly shortly before ovulation and follicular rupture

    Johannsen, Malene Louise, Poulsen, L. C., Mamsen, L. S., Grøndahl, M. L., Englund, A. L. M., Lauritsen, N. L., Carstensen, E. C., Styrishave, Bjarne & tcg964, tcg964, 2024, In: Human Reproduction. 39, 3, p. 578-585

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Is the unique benzodiazepine structure interacting with CYP enzymes to affect steroid synthesis in vitro?

    Johannsen, Malene Louise, Munkboel, C. H., Jørgensen, Flemming Steen & Styrishave, Bjarne, 2021, In: Journal of Steroid Biochemistry and Molecular Biology. 205, 10 p., 105765.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Visualization of penetration of topical antifungal drug substances through mycosis-infected nails by matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI)

    Joly-Tonetti, N., Pinto, F. E., Bagger, C., Osman-Ponchet, H. & Janfelt, Christian, 2021, In: Journal of the American Academy of Dermatology. 85, 3, p. AB191-AB191 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  10. Published

    Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

    Kalouta, Kleopatra, Stie, Mai Bay, Janfelt, Christian, Chronakis, I. S., Jacobsen, Jette, Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus

    Kamp-Jensen, Christina, Donslund, L. N., Styrishave, Bjarne, Jensen, Rigmor Højland & Westgate, C. S. J., 2024, In: Toxicology and Applied Pharmacology. 486, 11 p., 116919.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham.) K. Schum Leaves Analysed by Desorption Electrospray Ionisation Mass Spectrometry Imaging

    Kato, L., Moraes, A. P., de Oliveira, C. M. A., Vaz, B. G., de Almeida Gonçalves, L., E Silva, E. C. & Janfelt, Christian, 2018, In: Phytochemical Analysis. 29, p. 69-76

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Enantioselective mixture toxicity of the azole fungicide imazalil with the insecticide Α-cypermethrin in Chironomus riparius: Investigating the importance of toxicokinetics and enzyme interactions

    Kuhlmann, J., Kretschmann, A. C., Bester, K., Bollmann, U. E., Dalhoff, K. & Cedergreen, Nina, 1 Jun 2019, In: Chemosphere. 225, p. 166-173

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Quantification of Urinary Thymidine Dimers in Volunteers After Ultraviolet Radiation Using a New UPLC-MS/MS-based Method

    Lerche, Catharina Margrethe, Philipsen, P. A., Hermansson, S., Heydenreich, J. & Wulf, H. C., 2022, In: Anticancer Research. 42, 10, p. 5069-5076

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Quantifying urinary thymine dimers based on LC-MS/MS

    Lerche, Catharina Margrethe, Philipsen, P. A., Hermansson, S., Heydenreich, J. & Wulf, H. C., 2022, In: Anticancer Research. 42, 4, p. 2204-2204 22.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  16. Published

    High Oral Vitamin D3 Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice

    Lerche, Catharina Margrethe, Pinto, F. E., Philipsen, P. A., Bech, E. S., Jakobsen, J., Hædersdal, Merete & Wulf, H. C., 2022, In: Anticancer Research. 42, 10, p. 5083-5090

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Few X-ray and PUVA treatments accelerate photocarcinogenesis in hairless mice

    Lerche, Catharina Margrethe, Al-Chaer, R. N., Glud, M., Philipsen, P. A. & Wulf, H. C., 2021, In: Photochemical and Photobiological Sciences. 20, 10, p. 1299-1307

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?

    Lerche, Catharina Margrethe, Al-Chaer, R. N. & Wulf, H. C., 2023, In: Experimental Dermatology. 32, 4, p. 341-347

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    High oral vitamin D intake does not protect against UVR-induced squamous cell carcinoma in hairless mice

    Lerche, Catharina Margrethe, Pinto, F. E., Philipsen, P. A., Bech, E., Jakobsen, J., Hædersdal, Merete & Wulf, H. C., 2022, In: Anticancer Research. 42, 4, p. 2205-2205

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  20. Accepted/In press

    Urinary thymidine dimer excretion reflects personal ultraviolet radiation exposure levels

    Lerche, Catharina Margrethe, Frederiksen, N. J. S., Thorsteinsson, I. S., Køster, B., Nybo, Lars, Flouris, A. D., Heydenreich, J., Philipsen, P. A., Hædersdal, Merete, Wulf, H. C. & Granborg, J. R., 2024, (Accepted/In press) In: Photochemical and Photobiological Sciences.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer

    Li, Y., Ling Ma, N., Chen, H., Zhong, J., Zhang, D., Peng, W., Shiung Lam, S., Yang, Y., Yue, X., Yan, L., Wang, T., Styrishave, Bjarne, Maciej Ciesielski, T. & Sonne, C., 2023, In: Environment International. 181, 10 p., 108279.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging

    Lorensen, Marcus Daniel B B, Bjarnholt, Nanna, St-Pierre, B., Heinicke, S., Courdavault, V., O'Connor, S. & Janfelt, Christian, 2023, In: Phytochemistry. 209, 15 p., 113620.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids

    Lorensen, Marcus Daniel B B, Hayat, S. Y., Wellner, N., Bjarnholt, Nanna & Janfelt, Christian, 2023, In: Phytochemical Analysis. 34, 3, p. 269-279

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Tissue-specific stilbene accumulation is an early response to wounding/grafting as revealed by using spatial and temporal metabolomics

    Loupit, G., Fonayet, J. V., Lorensen, Marcus Daniel B B, Franc, C., De Revel, G., Janfelt, Christian & Cookson, S. J., 2023, In: Plant Cell and Environment. 46, 12, p. 3871-3886

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    A thiol-ene microfluidic device enabling continuous enzymatic digestion and electrophoretic separation as front-end to mass spectrometric peptide analysis

    Lu, N., Sticker, Drago, Kretschmann, A., Petersen, Nickolaj J. & Kutter, Jörg P., Jun 2020, In: Analytical and Bioanalytical Chemistry. 412, 15, p. 3559-3571 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Non-aqueous electrophoresis integrated with electrospray ionization mass spectrometry on a thiol-ene polymer-based microchip device

    Lu, N., Petersen, Nickolaj J., Kretschmann, A. C. & Kutter, Jörg P., 2021, In: Analytical and Bioanalytical Chemistry. 413, p. 4195–4205

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

    Mallia, V., Verhaegen, S., Styrishave, Bjarne, Eriksen, G. S., Johannsen, Malene Louise, Ropstad, E. & Uhlig, S., 2020, In: PLoS ONE. 15, 12, 18 p., 0244000.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging

    Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging

    Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Comparison of global DNA methylation analysis by whole genome bisulfite sequencing and the Infinium Mouse Methylation BeadChip using fresh and fresh-frozen mouse epidermis

    Meyer, Olivia Luxford, Andersen, M. M., Børsting, Claus, Morling, Niels, Wulf, H. C., Philipsen, P. A., Lerche, Catharina Margrethe & Andersen, Jeppe Dyrberg, 2023, In: Epigenetics. 18, 1, 10 p., 2144574 .

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Metabolites during Sorghum Germination

    Montini, L., Crocoll, C., Gleadow, R. M., Motawia, M. S., Janfelt, Christian & Bjarnholt, Nanna, 2020, In: Plant Physiology. 183, 3, p. 925-942 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice

    Morineau, L., Jacobsen, S. C., Kleberg, K., Hansen, Harald S. & Janfelt, Christian, 2 Dec 2018, In: Expert Opinion on Drug Delivery. 15, 12, p. 1157-1163

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    LC-MS/MS Method for Determination of Non-opioid Analgesics Adulterants in Herbal Medicines

    Mpanyakavili, A. L., Mwankuna, C. J., Mabiki, F. P. & Styrishave, Bjarne, 2022, In: Chemistry Africa. 5, p. 2149–2162

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro

    Munkboel, C. H., Christensen, L. R., Islin, J., Bonomo, S., Olsen, L., Jørgensen, Flemming Steen & Styrishave, Bjarne, Oct 2018, In: Biology of Reproduction. 99, 4, p. 888-897

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism

    Munkboel, C. H., Larsen, L. W., Weisser, J. J., Kristensen, D. M. & Styrishave, Bjarne, Jun 2018, In: Toxicological Sciences. 163, 2, p. 609-619

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats

    Munkboel, C. H., Baake, M. L. K. & Styrishave, Bjarne, May 2018, In: Archives of Toxicology. 92, 5, p. 1703-1715

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax

    Munkboel, C. H., Rasmussen, T. B., Elgaard, C., Olesen, M. L. K., Kretschmann, A. C. & Styrishave, Bjarne, 2019, In: Toxicology. 425, 152247.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3 beta-HSD inhibition

    Munkboel, C. H., Hasselstrom, S. B., Kristensen, D. M. & Styrishave, Bjarne, Apr 2018, In: Toxicology in Vitro. 48, p. 302-309

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Oral anti-diabetic drugs as endocrine disruptors in vitro - No evidence for additive effects in binary mixtures

    Munkboel, C. H., Hansen, H. S., Jessen, J. B., Johannsen, Malene Louise & Styrishave, Bjarne, 2021, In: Toxicology in Vitro. 70, 12 p., 105007.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Optimization of HPLC–MS/MS method for determination of antimalarial adulterants in herbal products

    Mwankuna, C. J., Kiros, F., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Mdegela, R. H. & Styrishave, Bjarne, 2023, In: Analytical Sciences. 39, p. 407-416

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Thin Layer Chromatographic Method for Detection of Conventional Drug Adulterants in Herbal Products

    Mwankuna, C. J., Mariki, E. E., Mabiki, F. P., Malebo, H. M., Styrishave, Bjarne & Mdegela, R. H., 2023, In: Separations. 10, 1, 10 p., 23.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    A HPLC-MS/MS method for screening of selected antibiotic adulterants in herbal drugs

    Mwankuna, C. J., Uwamaliya, G. A., Mariki, E. E., Mabiki, F., Malebo, H. M., Mdegela, R. & Styrishave, Bjarne, 2022, In: Analytical Methods. 14, 10, p. 1060-1068

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Mixture Effects of 3 Mechanistically Different Steroidogenic Disruptors (Prochloraz, Genistein, and Ketoconazole) in the H295R Cell Assay

    Nielsen, F. K., Hansen, C. H., Fey, J. A., Hansen, M., Halling-Sørensen, B., Björklund, E. & Styrishave, Bjarne, Nov 2015, In: International Journal of Toxicology. 34, 6, p. 534-42 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Nielsen, J. E., Rolland, A. D., Rajpert-De Meyts, E., Janfelt, Christian, Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, Anders, Chalmel, F., Jégou, B. & Skakkebæk, Niels Erik, 2019, In: Scientific Reports. 9, 1, 14 p., 12866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Repeated exposure to fractional CO2 laser delays squamous cell carcinoma formation and prevents clinical and subclinical photodamage visualized by line-field confocal optical coherence tomography and histology

    Olesen, U. H., Jacobsen, K., Lerche, Catharina Margrethe & Hædersdal, Merete, 2023, In: Lasers in Surgery and Medicine. 55, 1, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Anti-pd-1 therapy with adjuvant ablative fractional laser improves anti-tumor response in basal cell carcinomas

    Olesen, U. H., Wiinberg, M., Lerche, Catharina Margrethe, Jæhger, D. E., Andresen, T. L. & Hædersdal, Merete, 2021, In: Cancers. 13, 24, 14 p., 6326.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

    Otterbach, S. L., Yang, T., Kato, L., Janfelt, Christian & Geu-Flores, Fernando, 15 Oct 2019, In: Journal of Experimental Botany. 70, 20, p. 5799-5808

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  50. Published

    Assessment of the analgesic dipyrone as a possible (anti) androgenic endocrine disruptor

    Passoni, M. T., Kristensen, M. N., Morais, R. N., Woitkowiak, C., Boareto, A. C., da Silva Amaral, B. A., Grechi, N., Dalsenter, P. R., Munkboel, C. H., Styrishave, Bjarne, Kristensen, D. M., Gomes, C., van Ravenzwaay, B. & Martino-Andrade, A. J., 15 Mar 2018, In: Toxicology Letters. 285, p. 139-147

    Research output: Contribution to journal › Journal article › Research › peer-review

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