Physiological Pharmaceutics

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  1. 2021
  2. Published

    Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion

    Heerup, C., Ebbesen, M. F., Geng, X., Madsen, S. F., Berthelsen, R. & Mullertz, Anette , 2021, In: Food & Function. 12, 7, p. 2938-2949 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method

    Klitgaard, Mette, Mullertz, Anette & Berthelsen, R., 2021, In: Pharmaceutics. 13, 4, 14 p., 489.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films

    He, S., Jacobsen, Jette, Nielsen, C. U., Genina, Natalja, Østergaard, Jesper & Mu, Huiling, 2021, In: European Journal of Pharmaceutical Sciences. 163, 10 p., 105867.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates: Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools

    Bennett-Lenane, H., Jørgensen, J. R., Koehl, N. J., Henze, L. J., O'Shea, J. P., Mullertz, Anette & Griffin, B. T., 2021, In: European Journal of Pharmaceutical Sciences. 161, 11 p., 105778.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol

    Madsen, C. M., Plum, J., Hens, B., Augustijns, P., Mullertz, Anette & Rades, Thomas, 2021, In: Journal of Pharmaceutical Sciences. 110, 6, p. 2479-2488 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

    Dahlgren, D., Venczel, M., Ridoux, J. P., Skjöld, C., Mullertz, Anette , Holm, R., Augustijns, P., Hellström, P. M. & Lennernäs, H., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 163, p. 240-251

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Formulation optimization, anesthetic activity, skin permeation, and transportation pathway of Alpinia galanga oil SNEDDS in zebrafish (Danio rerio)

    Khumpirapang, N., Jørgensen, Louise von Gersdorff, Mullertz, Anette , Rades, Thomas & Okonogi, S., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 165, p. 193-202 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film

    Abid, Z., Andreoli, F., Kristensen, M. N., Petersen, R. S., Mullertz, Anette , Boisen, A. & Keller, S. S., 2021, In: Biomedical Microdevices. 23, 11 p., 37.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    INFOGEST inter-laboratory recommendations for assaying gastric and pancreatic lipases activities prior to in vitro digestion studies

    Grundy, M. M. L., Abrahamse, E., Almgren, A., Alminger, M., Andres, A., Ariëns, R. M. C., Bastiaan-Net, S., Bourlieu-Lacanal, C., Brodkorb, A., Bronze, M. R., Comi, I., Couëdelo, L., Dupont, D., Durand, A., El, S. N., Grauwet, T., Heerup, C., Heredia, A., Infantes Garcia, M. R., Jungnickel, C. & 26 others, Kłosowska-Chomiczewska, I. E., Létisse, M., Macierzanka, A., Mackie, A. R., McClements, D. J., Menard, O., Meynier, A., Michalski, M. C., Mulet-Cabero, A. I., Mullertz, Anette , Payeras Perelló, F. M., Peinado, I., Robert, M., Secouard, S., Serra, A. T., Silva, S. D., Thomassen, G., Tullberg, C., Undeland, I., Vaysse, C., Vegarud, G. E., Verkempinck, S. H. E., Viau, M., Zahir, M., Zhang, R. & Carrière, F., 2021, In: Journal of Functional Foods. 82, 104497.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops

    Mullertz, O., Nagstrup, Anne Hedengran, Mouhammad, Zaynab Ahmad, Freiberg, Josefine, Nagymihaly, R., Jacobsen, Jette, Larsen, Susan Weng, Bair, J., Utheim, T., Dartt, D. A., Heegaard, Steffen, Petrovski, G. & Kolko, Miriam, 2021, In: BMJ Open Ophthalmology. 6, 1, 7 p., 000892.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Microwave induced in situ amorphisation facilitated by crystalline hydrates

    Holm, T. P., Knopp, M. M., Löbmann, Korbinian & Berthelsen, R., 2021, In: European Journal of Pharmaceutical Sciences. 163, 9 p., 105858.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Microwave-Induced in Situ Drug Amorphization Using a Mixture of Polyethylene Glycol and Polyvinylpyrrolidone

    Hempel, N. J., Knopp, Matthias Manne, Zeitler, J. A., Berthelsen, R. & Löbmann, Korbinian, 2021, In: Journal of Pharmaceutical Sciences. 110, 9, p. 3221-3229

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Monitoring the Isothermal Dehydration of Crystalline Hydrates Using Low-Frequency Raman Spectroscopy

    Robert, C., Fraser-Miller, S. J., Bērziņš, Kārlis, Okeyo, P. O., Rantanen, Jukka, Rades, Thomas & Gordon, K. C., 2021, In: Molecular Pharmaceutics. 18, 3, p. 1264-1276

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir

    He, S., Radeke, C., Jacobsen, Jette, Lind, J. U. & Mu, Huiling, 2021, In: International Journal of Pharmaceutics. 610, 9 p., 121236.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model

    Falavigna, M., Klitgaard, Mette, Berthelsen, R., Mullertz, Anette & Flaten, G. E., 2021, In: Journal of Pharmaceutical Sciences. 110, 1, p. 208-216 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Predicting in vivo performance of fenofibrate amorphous solid dispersions using in vitro non-sink dissolution and dissolution permeation setup

    Lentz, K. A., Plum, J., Steffansen, B., Arvidsson, P. O., Omkvist, D. H., Pedersen, A. J., Sennbro, C. J., Pedersen, G. P. & Jacobsen, Jette, 2021, In: International Journal of Pharmaceutics. 610, 8 p., 121174.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs

    Falavigna, M., Brurok, S., Klitgaard, Mette & Flaten, G. E., 2021, In: International Journal of Pharmaceutics. 596, 9 p., 120258.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Studying the impact of the temperature and sorbed water during microwave-induced In Situ amorphization: A case study of celecoxib and polyvinylpyrrolidone

    Hempel, N. J., Knopp, Matthias Manne, Löbmann, Korbinian & Berthelsen, R., 2021, In: Pharmaceutics. 13, 6, 13 p., 886.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The Barriers and Facilitators of Different Stakeholders When Deprescribing Benzodiazepine Receptor Agonists in Older Patients-A Systematic Review

    Rasmussen, A. F., Poulsen, S. S., Oldenburg, L. I. K. & Vermehren, Charlotte, 2021, In: Metabolites. 11, 4, 12 p., 254.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    The Influence of Drug-Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

    Hempel, N., Merkl, P., Knopp, Matthias Manne, Berthelsen, R., Teleki, A., Sotiriou, G. A. & Löbmann, Korbinian, 2021, In: Pharmaceutics. 13, 6, 12 p., 917.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations

    Moller, A., Schultz, H. B., Meola, T. R., Mullertz, Anette & Prestidge, C. A., 2021, In: European Journal of Pharmaceutical Sciences. 157, 10 p., 105640.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The Influence of Temperature and Viscosity of Polyethylene Glycol on the Rate of Microwave-Induced In Situ Amorphization of Celecoxib

    Hempel, N., Dao, T., Knopp, Matthias Manne, Berthelsen, R. & Löbmann, Korbinian, 2021, In: Molecules. 26, 1, 8 p., 110.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The Use of Glycerol as an Enabling Excipient for Microwave-Induced In Situ Drug Amorphization

    Hempel, N., Morsch, F., Knopp, Matthias Manne, Berthelsen, R. & Löbmann, Korbinian, 2021, In: Journal of Pharmaceutical Sciences. 110, 1, p. 155-163 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Towards analyzing the potential of exosomes to deliver microRNA therapeutics

    Giassafaki, L. N., Siqueira, S., Panteris, E., Psatha, K., Chatzopoulou, F., Aivaliotis, M., Tzimagiorgis, G., Mullertz, Anette , Fatouros, D. G. & Vizirianakis, I. S., 2021, In: Journal of Cellular Physiology. 236, 2, p. 1529-1544 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Towards functional characterization of excipients for oral solid dosage forms using UV-vis imaging. Liberation, release and dissolution

    Li, Z., Sun, Y., Bar-Shalom, Daniel, Mu, Huiling, Larsen, Susan Weng, Jensen, H. & Østergaard, Jesper, 2021, In: Journal of Pharmaceutical and Biomedical Analysis. 194, 9 p., 113789.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

    Hempel, N. J., Merkl, P., Asad, S., Knopp, M. M., Berthelsen, R., Bergström, C. A. S., Teleki, A., Sotiriou, G. A. & Löbmann, Korbinian, 2021, In: Molecular Pharmaceutics. 18, 6, p. 2254–2262

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

    Strindberg, S., Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices

    Kjeldsen, R. B., Kristensen, M. N., Gundlach, C., Thamdrup, L. H. E., Mullertz, Anette , Rades, Thomas, Nielsen, L. H., Zór, K. & Boisen, A., 2021, In: ACS Biomaterials Science and Engineering. 7, 6, p. 2538–2547

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. 2020
  31. Published

    Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

    Stie, Mai Bay, Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 15 Aug 2020, In: Carbohydrate Polymers. 242, 10 p., 116428.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Six years of progress in the oral biopharmaceutics area – A summary from the IMI OrBiTo project

    Abrahamsson, B., Mcallister, M., Augustijns, P., Zane, P., Butler, J., Holm, R., Langguth, P., Lindahl, A., Mullertz, Anette , Pepin, X., Rostami-hodjegan, A., Sjögren, E., Berntsson, M. & Lennernäs, H., 1 Jul 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 236-247 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor

    Strindberg, S., Plum, J., Stie, Mai Bay, Christiansen, M. L., Nielsen, L. H., Rades, Thomas & Mullertz, Anette , Jun 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 108-115

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    The influence of drug and polymer particle size on the in situ amorphization using microwave irradiation

    Hempel, N. J., Knopp, Matthias Manne, Berthelsen, R., Zeitler, J. A. & Löbmann, Korbinian, Apr 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 149, p. 77-84 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

    Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In: Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Poorly soluble drugs

    Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In: International Journal of Pharmaceutics. 577, 119055.

    Research output: Contribution to journal › Editorial › Research

  37. Published

    In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

    Jørgensen, J. R., Yu, F., Ramakrishnan, V., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In: Pharmaceutics. 12, 1, 14 p., 48.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Comparison of induction methods for supersaturation: pH shift versus solvent shift

    Plum, J., Bavnhoj, C., Palmelund, H., Perez-Alos, L., Mullertz, Anette & Rades, Thomas, 5 Jan 2020, In: International Journal of Pharmaceutics. 573, 8 p., 118862.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

    Christensen, B., Karlsen, N. J., Jorgensen, S. D. S., Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In: Journal of Dairy Science. 103, 1, p. 42-51

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Achieving delayed release of freeze-dried probiotic strains by extrusion, spheronization and fluid bed coating - evaluated using a three-step in vitro model

    Jacobsen, N. M. Y., Caglayan, I., Caglayan, A., Bar-Shalom, Daniel & Mullertz, Anette , 2020, In: International Journal of Pharmaceutics. 591, 7 p., 120022.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Adding a Gastric Step to the Intestinal In Vitro Digestion Model Improves the Prediction of Pharmacokinetic Data in Beagle Dogs of Two Lipid-Based Drug Delivery Systems

    Klitgaard, Mette, Beilles, S., Sassene, P. J., Berthelsen, R. & Mullertz, Anette , 2020, In: Molecular Pharmaceutics. 17, 9, p. 3214-3222 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    An Ingestible Self-Polymerizing System for Targeted Sampling of Gut Microbiota and Biomarkers

    Chen, L., Gruzinskyte, L., Jorgensen, S. L., Boisen, A. & Srivastava, S. K., 2020, In: ACS Nano. 14, 9, p. 12072-12081 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Betaxolol Ophthalmic Solution as Alternative Treatment for Patients with Timolol Allergy: A Case Report

    Müllertz, O., Jacobsen, Jette, Thyssen, Jacob Pontoppidan, Horwitz, Anna & Kolko, Miriam, 2020, In: Reports — Medical Cases, Images, and Videos. 3, 3, 4 p., 21.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge

    Treldal, C., Petersen, Janne, Mogensen, S., Therkildsen, C., Jacobsen, Jette, Andersen, Ove & Pedersen, Anne Marie Lynge, 2020, In: Oral Diseases. 26, 3, p. 656-669 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Comparison of induction methods for supersaturation: Amorphous dissolution versus solvent shift

    Plum, J., Bavnhoj, C. G., Eliasen, Jannik Nicklas, Rades, Thomas & Mullertz, Anette , 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 35-43 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Convection-Induced vs. Microwave Radiation-Induced in situ Drug Amorphization

    Hempel, N., Knopp, Matthias Manne, Berthelsen, R. & Löbmann, Korbinian, 2020, In: Molecules. 25, 5, 7 p., 1068.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Direct Measurement of Lateral Molecular Diffusivity on the Surface of Supersaturated Amorphous Solid Dispersions by Atomic Force Microscopy

    Bannow, J., Karl, M., Larsen, P. E., Hwu, E. T. & Rades, Thomas, 2020, In: Molecular Pharmaceutics. 17, 5, p. 1715-1722 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Effect of centrifugation speed on the measured equilibrium solubility of poorly water-soluble compounds in viscous solvents

    Liu, X., Mullertz, Anette , Bar-Shalom, Daniel & Berthelsen, R., 2020, In: Journal of Drug Delivery Science and Technology. 59, 8 p., 101853.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

    Kalouta, Kleopatra, Stie, Mai Bay, Janfelt, Christian, Chronakis, I. S., Jacobsen, Jette, Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Enhancing Stability and Tooth Bleaching Activity of Carbamide Peroxide by Electrospun Nanofibrous Film

    Okonogi, S., Kaewpinta, A., Rades, Thomas, Mullertz, Anette , Yang, Mingshi, Khongkhunthian, S. & Chaijareenont, P., 2020, In: Pharmaceuticals. 13, 11, 20 p., 381.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Evaluating side-by-side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

    Eliasen, Jannik Nicklas, Berthelsen, R., Slot, A. L. & Mullertz, Anette , 2020, In: Journal of Pharmacy and Pharmacology. 72, 3, p. 371-384

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Evaluation of self -emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis

    Liu, J., Hirschberg, C., Fano, M., Mu, Huiling & Mullertz, Anette , 2020, In: European Journal of Pharmaceutical Sciences. 147, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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