- Published
In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B
Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., 2020, In: Pharmaceutics. 12, 8, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies
Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In: Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of oral gavage technique of drug-containing microcontainers on the gastrointestinal transit and absorption in rats
Kristensen, M. N., Rades, Thomas, Boisen, A. & Mullertz, Anette , 2022, In: International Journal of Pharmaceutics. 618, 121630.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)
Kubackova, J., Holas, O., Zbytovska, J., Vranikova, B., Zeng, G., Pavek, P. & Mullertz, Anette , Apr 2021, In: Pharmaceutics. 13, 4, 27 p., 459.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predicting in vivo performance of fenofibrate amorphous solid dispersions using in vitro non-sink dissolution and dissolution permeation setup
Lentz, K. A., Plum, J., Steffansen, B., Arvidsson, P. O., Omkvist, D. H., Pedersen, A. J., Sennbro, C. J., Pedersen, G. P. & Jacobsen, Jette, 2021, In: International Journal of Pharmaceutics. 610, 8 p., 121174.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading
Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In: International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers
Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2743-51 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Towards functional characterization of excipients for oral solid dosage forms using UV-vis imaging. Liberation, release and dissolution
Li, Z., Sun, Y., Bar-Shalom, Daniel, Mu, Huiling, Larsen, Susan Weng, Jensen, H. & Østergaard, Jesper, 2021, In: Journal of Pharmaceutical and Biomedical Analysis. 194, 9 p., 113789.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems
Liu, J., Hwu, E., Bannow, J., Grohganz, Holger & Rades, Thomas, 2022, In: Molecular Pharmaceutics. 19, 4, p. 1183-1190Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of self -emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis
Liu, J., Hirschberg, C., Fano, M., Mu, Huiling & Mullertz, Anette , 2020, In: European Journal of Pharmaceutical Sciences. 147, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats
Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, Lasse, Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In: International Journal of Pharmaceutics. 560, p. 377-384Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amphotericin B and monoacyl-phosphatidylcholine form a stable amorphous complex
Liu, X., Berthelsen, R., Bar-Shalom, Daniel, Kjellerup Lind, T., Doutch, J. & Mullertz, Anette , 2023, In: International Journal of Pharmaceutics. 633, 10 p., 122601.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of centrifugation speed on the measured equilibrium solubility of poorly water-soluble compounds in viscous solvents
Liu, X., Mullertz, Anette , Bar-Shalom, Daniel & Berthelsen, R., 2020, In: Journal of Drug Delivery Science and Technology. 59, 8 p., 101853.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads: Experimental studies and molecular dynamics analysis
Lugtu-Pe, J. A., Zhang, X., Mirzaie, S., Chang, H. H. R., AL-Mousawi, N., Chen, K., Li, Y., Kane, A., Bar-Shalom, Daniel & Wu, X. Y., 2024, (Accepted/In press) In: Acta Pharmaceutica Sinica B.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The interplay between trehalose and dextran as spray drying precursors for cationic liposomes
Lutta, A., Knopp, Matthias Manne, Tollemeto, M., Pedersen, Gabriel Kristian, Schmidt, S. T., Grohganz, Holger & Hagner Nielsen, L., 2024, In: International Journal of Pharmaceutics. 652, 10 p., 123798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol
Madsen, C. M., Plum, J., Hens, B., Augustijns, P., Mullertz, Anette & Rades, Thomas, 2021, In: Journal of Pharmaceutical Sciences. 110, 6, p. 2479-2488 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments
Madsen, C. M., Feng, K., Leithead, A., Canfield, N., Jørgensen, S. A., Mullertz, Anette & Rades, Thomas, Jan 2018, In: European Journal of Pharmaceutical Sciences. 111, p. 311-319 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Permeability Barriers for Nicotine and Mannitol in Porcine Buccal. Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging
Marxen, E., Jacobsen, Jette, Hyrup, B. & Janfelt, Christian, 5 Feb 2018, In: Molecular Pharmaceutics. 15, 2, p. 519-526Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging
Marxen, E., Jin, L., Jacobsen, Jette, Janfelt, Christian, Hyrup, B. & Nicolazzo, J. A., 21 Feb 2018, In: Pharmaceutical Research. 35, 3, 12 p., 70.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymeric Lids for Microcontainers for Oral Protein Delivery
Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, J. R., Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In: Macromolecular Bioscience. 19, 5, 1900004.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs
Meng-Lund, E., Jacobsen, Jette, Mullertz, Anette , Jørgensen, E. B. & Holm, R., 30 Sep 2016, In: International Journal of Pharmaceutics. 515, 1-2, p. 125-131 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functionalized calcium carbonate (FCC) as a novel carrier to solidify supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)
Merchant, J., Mullertz, Anette , Rades, Thomas & Bannow, J., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 198-207Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats
Michaelsen, M. H., Siqueira Jørgensen, S. D., Abdi, I. M., Wasan, K. M., Rades, Thomas & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 258-264 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects
Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations
Moller, A., Schultz, H. B., Meola, T. R., Mullertz, Anette & Prestidge, C. A., 2021, In: European Journal of Pharmaceutical Sciences. 157, 10 p., 105640.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid lipid nanocarriers in drug delivery: characterization and design
Mu, Huiling & Holm, R., Aug 2018, In: Expert Opinion on Drug Delivery. 15, 8, p. 771-785 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops
Mullertz, O., Nagstrup, Anne Hedengran, Mouhammad, Zaynab Ahmad, Freiberg, Josefine, Nagymihaly, R., Jacobsen, Jette, Larsen, Susan Weng, Bair, J., Utheim, T., Dartt, D. A., Heegaard, Steffen, Petrovski, G. & Kolko, Miriam, 2021, In: BMJ Open Ophthalmology. 6, 1, 7 p., 000892.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Influence of Blonanserin Supersaturation in Liquid and Silica Stabilised Self-Nanoemulsifying Drug Delivery Systems on In Vitro Solubilisation
Møller, Amalie Lykkemark, Schultz, H. B., Meola, T. R., Joyce, P., Mullertz, Anette & Prestidge, C. A., 2023, In: Pharmaceutics. 15, 1, 14 p., 284.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Betaxolol Ophthalmic Solution as Alternative Treatment for Patients with Timolol Allergy: A Case Report
Müllertz, O., Jacobsen, Jette, Thyssen, Jacob Pontoppidan, Horwitz, A. & Kolko, Miriam, 2020, In: Reports — Medical Cases, Images, and Videos. 3, 3, 4 p., 21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The physicochemical properties of preserved and preservative-free latanoprost eye drops and their impact on human conjunctival goblet cells
Müllertz, O. A. O., Nagstrup, Anne Hedengran, Mouhammad, Zaynab Ahmad, Freiberg, Josefine, Nagymihály, R., Jacobsen, Jette, Larsen, Susan Weng, Bair, J. A., Utheim, T. P., Dartt, D. A., Heegaard, Steffen, Petrovski, G. & Kolko, Miriam, 2022, In: Acta Ophthalmologica. 100, S267Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug
Nora, G., Venkatasubramanian, R., Strindberg, S., Siqueira-Jørgensen, S. D., Pagano, L., Romanski, F. S., Swarnakar, N. K., Rades, Thomas & Mullertz, Anette , 2022, In: Journal of Controlled Release. 349, p. 206-212Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in inorganic porous excipients
Ogadah, C. U., Mrštná, K., Matysová, L., Mullertz, Anette , Rades, Thomas, Niederquell, A., Šklubalová, Z. & Vraníková, B., 2024, In: International Journal of Pharmaceutics. 650, 10 p., 123702.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single particles as resonators for thermomechanical analysis
Okeyo, P. O., Larsen, P. E., Kissi, E. O., Ajalloueian, F., Rades, Thomas, Rantanen, Jukka & Boisen, A., 2020, In: Nature Communications. 11, 1, 11 p., 1235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Imaging of dehydration in particulate matter using Raman line-focus microscopy
Okeyo, P. O., Ilchenko, O., Slipets, R., Larsen, P. E., Boisen, A., Rades, Thomas & Rantanen, Jukka, 17 May 2019, In: Scientific Reports. 9, 11 p., 7525.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans
Okonogi, S., Phumat, P., Khongkhunthian, S., Chaijareenont, P., Rades, Thomas & Mullertz, Anette , 2021, In: Pharmaceutics. 13, 2, 16 p., 167.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enhancing Stability and Tooth Bleaching Activity of Carbamide Peroxide by Electrospun Nanofibrous Film
Okonogi, S., Kaewpinta, A., Rades, Thomas, Mullertz, Anette , Yang, Mingshi, Khongkhunthian, S. & Chaijareenont, P., 2020, In: Pharmaceuticals. 13, 11, 20 p., 381.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of the analgesic dipyrone as a possible (anti) androgenic endocrine disruptor
Passoni, M. T., Kristensen, M. N., Morais, R. N., Woitkowiak, C., Boareto, A. C., da Silva Amaral, B. A., Grechi, N., Dalsenter, P. R., Munkboel, C. H., Styrishave, Bjarne, Kristensen, D. M., Gomes, C., van Ravenzwaay, B. & Martino-Andrade, A. J., 15 Mar 2018, In: Toxicology Letters. 285, p. 139-147Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine
Pedersen, P. B., Berthelsen, R., Rades, Thomas, Jørgensen, S. A., Vilmann, Peter, Bar-Shalom, Daniel, Baldursdottir, S. & Mullertz, Anette , 2022, In: International Journal of Pharmaceutics. 622, 7 p., 121856.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Digestive Enzyme Corona Formed in the Gastrointestinal Tract and Its Impact on Epithelial Cell Uptake of Nanoparticles
Peng, Q., Liu, J., Zhang, T., Zhang, T., Zhang, C. & Mu, Huiling, 8 Apr 2019, In: Biomacromolecules. 20, 4, p. 1789-1797 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of induction methods for supersaturation: pH shift versus solvent shift
Plum, J., Bavnhoj, C., Palmelund, H., Perez-Alos, L., Mullertz, Anette & Rades, Thomas, 5 Jan 2020, In: International Journal of Pharmaceutics. 573, 8 p., 118862.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of induction methods for supersaturation: Amorphous dissolution versus solvent shift
Plum, J., Bavnhoj, C. G., Eliasen, Jannik Nicklas, Rades, Thomas & Mullertz, Anette , 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 35-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nutritional properties and oxidation of marine lipid: Effects of dietary triacylglycerol structure on plasma and liver lipid levels in rats fed low-fat diets containing n-3 polyunsaturated fatty acids of marine origin
Porsgaard, T., Xu, X. & Mu, Huiling, 1 Dec 2006, Seafood Research from Fish to Dish: Quality, Safety and Processing of Wild and Farmed Seafood. Wageningen Academic Publishers, p. 29-40 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Drug Dissolution in Oral Drug Absorption: Workshop Report
Raines, K., Agarwal, P., Augustijns, P., Alayoubi, A., Attia, L., Bauer-Brandl, A., Brandl, M., Chatterjee, P., Chen, H., Yu, Y. C., Coutant, C., Coutinho, A. L., Curran, D., Dressman, J., Ericksen, B., Falade, L., Gao, Y., Gao, Z., Ghosh, D., Ghosh, T. & 26 others, , 2023, In: AAPS Journal. 25, 6, 20 p., 103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Barriers and Facilitators of Different Stakeholders When Deprescribing Benzodiazepine Receptor Agonists in Older Patients-A Systematic Review
Rasmussen, A. F., Poulsen, S. S., Oldenburg, L. I. K. & Vermehren, Charlotte, 2021, In: Metabolites. 11, 4, 12 p., 254.Research output: Contribution to journal › Review › Research › peer-review
- Published
Monitoring the Isothermal Dehydration of Crystalline Hydrates Using Low-Frequency Raman Spectroscopy
Robert, C., Fraser-Miller, S. J., Bērziņš, Kārlis, Okeyo, P. O., Rantanen, Jukka, Rades, Thomas & Gordon, K. C., 2021, In: Molecular Pharmaceutics. 18, 3, p. 1264-1276Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement
Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems
Sassene, P. J., Michaelsen, M. H., Mosgaard, M. D., Klitgaard, Mette, Van Den Broek, E., Wasan, K. M., Mu, Huiling, Rades, Thomas & Mullertz, Anette , 3 Oct 2016, In: Molecular Pharmaceutics. 13, 10, p. 3417-3426 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate
Sassene, P. J., Knopp, Matthias Manne, Hesselkilde, J. Z., Koradia, V., Larsen, A., Rades, Thomas & Mullertz, Anette , 2010, In: Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products [incl, correction]
Selen, A., Mullertz, Anette , Kesisoglou, F., Ho, R. J. Y., Cook, J. A., Dickinson, P. A. & Flanagan, T., 2020, In: AAPS Journal. 22, 5, 20 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development of a Microgram Scale Video-Microscopic Method to Investigate Dissolution Behavior of Poorly Water-Soluble Drugs
Senniksen, M. B., Christfort, J. F., Marabini, R., Spillum, E., Matthews, W., Da Vià, L., Plum, J., Rades, Thomas & Mullertz, Anette , 2022, In: AAPS PharmSciTech. 23, 6, 173.Research output: Contribution to journal › Journal article › Research › peer-review
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Rhamnogalacturonan-I based microcapsules for targeted drug release
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Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease
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Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil
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The interplay between trehalose and dextran as spray drying precursors for cationic liposomes
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