[99mTc]diphosphonate uptake and hemodynamics in experimental arthritis: effect of naproxen in the canine carrageenan injection model
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The impact of naproxen treatment on juxta-articular hemodynamics and bone metabolism in experimental juvenile arthritis was studied in the articular carrageenan injection model. Unilateral gonarthritis was induced for 12 weeks in eight dogs receiving naproxen (dosage, 2 mg/kg) and eight controls. Regional blood flow was assessed by the microsphere method, plasma volume by the distribution space of [125I]fibrinogen, and bone metabolism by the 2-h uptake of [99mTc]diphosphonate ([99mTc]DPD). Synovial effusion was less prominent with naproxen treatment as judged by joint fluid volume and pressure. Naproxen reduced the arthritic capsular hyperemia, almost normalized a severe blood flow increase in patella and both juxta-articular epiphyses, ameliorated an expansion of plasma volume in the patella and the distal femoral epiphysis, and normalized an increased [99mTc]DPD uptake in subchondral femoral bone and the tibial cortex. Significantly increased arteriovenous shunting in the arthritic extremity was unaffected by naproxen. The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation.
Original language | English |
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Journal | Journal of Orthopaedic Research |
Volume | 10 |
Issue number | 5 |
Pages (from-to) | 647-56 |
Number of pages | 10 |
ISSN | 0736-0266 |
DOIs | |
Publication status | Published - Sep 1992 |
- Animals, Arthritis/chemically induced, Bone and Bones/blood supply, Capillary Permeability/physiology, Carrageenan/administration & dosage, Diphosphonates/pharmacokinetics, Disease Models, Animal, Dogs, Growth Plate/blood supply, Hemodynamics/drug effects, Homeostasis, Injections, Microspheres, Naproxen/pharmacology, Regional Blood Flow, Technetium/pharmacokinetics, Technetium Compounds
Research areas
ID: 244280179