Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats

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Standard

Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats. / Mu, Huiling; Høy, Carl-Erik.

In: Lipids, Vol. 37, No. 3, 2002, p. 329-31.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mu, H & Høy, C-E 2002, 'Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats', Lipids, vol. 37, no. 3, pp. 329-31.

APA

Mu, H., & Høy, C-E. (2002). Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats. Lipids, 37(3), 329-31.

Vancouver

Mu H, Høy C-E. Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats. Lipids. 2002;37(3):329-31.

Author

Mu, Huiling ; Høy, Carl-Erik. / Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats. In: Lipids. 2002 ; Vol. 37, No. 3. pp. 329-31.

Bibtex

@article{4e924f5cc33c4d9598dcbbe40634d7e6,
title = "Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats",
abstract = "Structured TAG (STAG) containing medium-chain FA (MCFA) in the sn-1,3 positions and essential FA in the sn-2 position were synthesized by lipase-catalyzed acidolysis. In our previous studies we found that part of the MCFA from STAG could be absorbed in the small intestine; however, it was unclear how they were absorbed. In order to get a better understanding of the metabolism of STAG to improve future design and application of STAG, in the present study lymph lipids collected after feeding STAG were fractionated into different classes and the FA composition of each lipid class was studied by GC after methylation to FAME. Caprylic acid was detected in the fraction of TAG only after administration of 1,3-dioctanoyl-2-linoleyl-sn-glycerol (8:0/18:2/8:0), whereas lauric acid was detected in TAG, DAG, and FFA as well as phospholipids after administration of 1,3-didodecanoyl-2-linoleyl-sn-glycerol (12:0/18:2/12:0). We conclude that the enterocyte has the ability to reacylate the MCFA into TAG and that the intestinal absorption of MCFA from STAG mainly occurs by resynthesis of TAG. Caprylic acid from STAG is not incorporated into phospholipids, whereas lauric acid from STAG can be incorporated into phospholipids.",
author = "Huiling Mu and Carl-Erik H{\o}y",
year = "2002",
language = "English",
volume = "37",
pages = "329--31",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats

AU - Mu, Huiling

AU - Høy, Carl-Erik

PY - 2002

Y1 - 2002

N2 - Structured TAG (STAG) containing medium-chain FA (MCFA) in the sn-1,3 positions and essential FA in the sn-2 position were synthesized by lipase-catalyzed acidolysis. In our previous studies we found that part of the MCFA from STAG could be absorbed in the small intestine; however, it was unclear how they were absorbed. In order to get a better understanding of the metabolism of STAG to improve future design and application of STAG, in the present study lymph lipids collected after feeding STAG were fractionated into different classes and the FA composition of each lipid class was studied by GC after methylation to FAME. Caprylic acid was detected in the fraction of TAG only after administration of 1,3-dioctanoyl-2-linoleyl-sn-glycerol (8:0/18:2/8:0), whereas lauric acid was detected in TAG, DAG, and FFA as well as phospholipids after administration of 1,3-didodecanoyl-2-linoleyl-sn-glycerol (12:0/18:2/12:0). We conclude that the enterocyte has the ability to reacylate the MCFA into TAG and that the intestinal absorption of MCFA from STAG mainly occurs by resynthesis of TAG. Caprylic acid from STAG is not incorporated into phospholipids, whereas lauric acid from STAG can be incorporated into phospholipids.

AB - Structured TAG (STAG) containing medium-chain FA (MCFA) in the sn-1,3 positions and essential FA in the sn-2 position were synthesized by lipase-catalyzed acidolysis. In our previous studies we found that part of the MCFA from STAG could be absorbed in the small intestine; however, it was unclear how they were absorbed. In order to get a better understanding of the metabolism of STAG to improve future design and application of STAG, in the present study lymph lipids collected after feeding STAG were fractionated into different classes and the FA composition of each lipid class was studied by GC after methylation to FAME. Caprylic acid was detected in the fraction of TAG only after administration of 1,3-dioctanoyl-2-linoleyl-sn-glycerol (8:0/18:2/8:0), whereas lauric acid was detected in TAG, DAG, and FFA as well as phospholipids after administration of 1,3-didodecanoyl-2-linoleyl-sn-glycerol (12:0/18:2/12:0). We conclude that the enterocyte has the ability to reacylate the MCFA into TAG and that the intestinal absorption of MCFA from STAG mainly occurs by resynthesis of TAG. Caprylic acid from STAG is not incorporated into phospholipids, whereas lauric acid from STAG can be incorporated into phospholipids.

M3 - Journal article

C2 - 11942486

VL - 37

SP - 329

EP - 331

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 3

ER -

ID: 44091348