Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa
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Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa. / Zhang, Qicheng; Zhang, Ming; Huang, Zheng; Sun, Yi; Ye, Lei.
In: ACS Applied Polymer Materials, Vol. 5, No. 4, 2023, p. 3055–3064.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa
AU - Zhang, Qicheng
AU - Zhang, Ming
AU - Huang, Zheng
AU - Sun, Yi
AU - Ye, Lei
N1 - Funding Information: The authors are grateful for financial support from the Swedish Research Council VR (grant number 2019-04228) and the Novo Nordisk Foundation of Denmark (grant NNF21OC0066562). Q.Z. was awarded a Ph.D. fellowship by the China Scholarship Council. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.
PY - 2023
Y1 - 2023
N2 - Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseudomonas aeruginosa was selected as a template due to its cis-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function and imprinting efficiency. The combination of bacteria-imprinting with photothermal ability allowed PMIP to deactivate target bacteria with enhanced precision and efficiency. Taken together, our study offers a promising strategy to design synthetic materials for targeting and treating pathogens for various infectious diseases and expands the application of molecular imprinting technology in the field of antimicrobials.
AB - Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseudomonas aeruginosa was selected as a template due to its cis-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function and imprinting efficiency. The combination of bacteria-imprinting with photothermal ability allowed PMIP to deactivate target bacteria with enhanced precision and efficiency. Taken together, our study offers a promising strategy to design synthetic materials for targeting and treating pathogens for various infectious diseases and expands the application of molecular imprinting technology in the field of antimicrobials.
KW - Bacteria
KW - Boronate affinity
KW - Lipopolysaccharide
KW - Molecular imprinting
KW - Photothermal agent
U2 - 10.1021/acsapm.3c00204
DO - 10.1021/acsapm.3c00204
M3 - Journal article
AN - SCOPUS:85152200521
VL - 5
SP - 3055
EP - 3064
JO - ACS Applied Polymer Materials
JF - ACS Applied Polymer Materials
SN - 2637-6105
IS - 4
ER -
ID: 344707980