α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring. / Guo, Xiong; Liu, Yunen; Bera, Hriday; Zhang, Haotian; Chen, Yang; Cun, Dongmei; Foderà, Vito; Yang, Mingshi.

In: A C S Applied Materials and Interfaces, Vol. 12, No. 41, 2020, p. 45702-45713.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Guo, X, Liu, Y, Bera, H, Zhang, H, Chen, Y, Cun, D, Foderà, V & Yang, M 2020, 'α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring', A C S Applied Materials and Interfaces, vol. 12, no. 41, pp. 45702-45713. https://doi.org/10.1021/acsami.0c05175

APA

Guo, X., Liu, Y., Bera, H., Zhang, H., Chen, Y., Cun, D., Foderà, V., & Yang, M. (2020). α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring. A C S Applied Materials and Interfaces, 12(41), 45702-45713. https://doi.org/10.1021/acsami.0c05175

Vancouver

Guo X, Liu Y, Bera H, Zhang H, Chen Y, Cun D et al. α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring. A C S Applied Materials and Interfaces. 2020;12(41):45702-45713. https://doi.org/10.1021/acsami.0c05175

Author

Guo, Xiong ; Liu, Yunen ; Bera, Hriday ; Zhang, Haotian ; Chen, Yang ; Cun, Dongmei ; Foderà, Vito ; Yang, Mingshi. / α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring. In: A C S Applied Materials and Interfaces. 2020 ; Vol. 12, No. 41. pp. 45702-45713.

Bibtex

@article{17e3a72683034f7493d4bd29251188da,
title = "α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring",
abstract = "Skin wound especially burn injury is a major threat for public health. One of the pursuits in the current wound healing research is to identify new promising biological materials, which can not only promote tissue repair but also reduce scar formation. In this current study, the potentials of α-lactalbumin (ALA), a tryptophan-rich dietary protein acting as a precursor of neurotransmitter serotonin, to promote the burn wound healing and reduce the scar formation were investigated. The ALA was initially electrospun with polycaprolactone (PCL) to accomplish electrospun nanofibrous mats (ENMs), subsequently assessed for their physicochemical attributes and wound healing efficiency on a burn rat model, and then their healing mechanisms at cellular and molecular levels were explored. The results showed that ALA and PCL were physicochemically compatible in ENMs. The average diameter of various nanofibers was within 183-344 nm. Their wettability and mechanical properties could be readily modulated by adjusting the mass ratios of ALA and PCL from 1/9 to 1/2. The selected ENMs exhibited negligible cytotoxicity and satisfactory adhesion to fibroblasts and promoting the proliferation of the fibroblasts. As compared to pristine PCL based ENMs, the composite scaffolds could accelerate the wound healing process and exhibit effects comparable to a marketed wound dressing over 16 days. Moreover, the ALA/PCL based ENMs could increase the synthesis of type I collagen and decrease the expression of α-smooth muscle actin, conferring that the novel wound dressings could reduce the formation of scars. Collectively, this study demonstrates that the ALA is a promising biological material and could promote the regeneration of burn skins with reduced scar formation, when being loaded on ultrafine fibrous scaffolds, mimicking the structure of the natural extra cellular matrix.",
author = "Xiong Guo and Yunen Liu and Hriday Bera and Haotian Zhang and Yang Chen and Dongmei Cun and Vito Foder{\`a} and Mingshi Yang",
year = "2020",
doi = "10.1021/acsami.0c05175",
language = "English",
volume = "12",
pages = "45702--45713",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "41",

}

RIS

TY - JOUR

T1 - α-Lactalbumin-Based Nanofiber Dressings Improve Burn Wound Healing and Reduce Scarring

AU - Guo, Xiong

AU - Liu, Yunen

AU - Bera, Hriday

AU - Zhang, Haotian

AU - Chen, Yang

AU - Cun, Dongmei

AU - Foderà, Vito

AU - Yang, Mingshi

PY - 2020

Y1 - 2020

N2 - Skin wound especially burn injury is a major threat for public health. One of the pursuits in the current wound healing research is to identify new promising biological materials, which can not only promote tissue repair but also reduce scar formation. In this current study, the potentials of α-lactalbumin (ALA), a tryptophan-rich dietary protein acting as a precursor of neurotransmitter serotonin, to promote the burn wound healing and reduce the scar formation were investigated. The ALA was initially electrospun with polycaprolactone (PCL) to accomplish electrospun nanofibrous mats (ENMs), subsequently assessed for their physicochemical attributes and wound healing efficiency on a burn rat model, and then their healing mechanisms at cellular and molecular levels were explored. The results showed that ALA and PCL were physicochemically compatible in ENMs. The average diameter of various nanofibers was within 183-344 nm. Their wettability and mechanical properties could be readily modulated by adjusting the mass ratios of ALA and PCL from 1/9 to 1/2. The selected ENMs exhibited negligible cytotoxicity and satisfactory adhesion to fibroblasts and promoting the proliferation of the fibroblasts. As compared to pristine PCL based ENMs, the composite scaffolds could accelerate the wound healing process and exhibit effects comparable to a marketed wound dressing over 16 days. Moreover, the ALA/PCL based ENMs could increase the synthesis of type I collagen and decrease the expression of α-smooth muscle actin, conferring that the novel wound dressings could reduce the formation of scars. Collectively, this study demonstrates that the ALA is a promising biological material and could promote the regeneration of burn skins with reduced scar formation, when being loaded on ultrafine fibrous scaffolds, mimicking the structure of the natural extra cellular matrix.

AB - Skin wound especially burn injury is a major threat for public health. One of the pursuits in the current wound healing research is to identify new promising biological materials, which can not only promote tissue repair but also reduce scar formation. In this current study, the potentials of α-lactalbumin (ALA), a tryptophan-rich dietary protein acting as a precursor of neurotransmitter serotonin, to promote the burn wound healing and reduce the scar formation were investigated. The ALA was initially electrospun with polycaprolactone (PCL) to accomplish electrospun nanofibrous mats (ENMs), subsequently assessed for their physicochemical attributes and wound healing efficiency on a burn rat model, and then their healing mechanisms at cellular and molecular levels were explored. The results showed that ALA and PCL were physicochemically compatible in ENMs. The average diameter of various nanofibers was within 183-344 nm. Their wettability and mechanical properties could be readily modulated by adjusting the mass ratios of ALA and PCL from 1/9 to 1/2. The selected ENMs exhibited negligible cytotoxicity and satisfactory adhesion to fibroblasts and promoting the proliferation of the fibroblasts. As compared to pristine PCL based ENMs, the composite scaffolds could accelerate the wound healing process and exhibit effects comparable to a marketed wound dressing over 16 days. Moreover, the ALA/PCL based ENMs could increase the synthesis of type I collagen and decrease the expression of α-smooth muscle actin, conferring that the novel wound dressings could reduce the formation of scars. Collectively, this study demonstrates that the ALA is a promising biological material and could promote the regeneration of burn skins with reduced scar formation, when being loaded on ultrafine fibrous scaffolds, mimicking the structure of the natural extra cellular matrix.

U2 - 10.1021/acsami.0c05175

DO - 10.1021/acsami.0c05175

M3 - Journal article

C2 - 32667794

VL - 12

SP - 45702

EP - 45713

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

SN - 1944-8244

IS - 41

ER -

ID: 250377266