Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals

Research output: Contribution to journal › Review › Research › peer-review

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Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. / Kristensen, Mie; Nielsen, Hanne Mørck.

In: Tissue Barriers, Vol. 4, No. 2, e1178369, 2016.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Kristensen, M & Nielsen, HM 2016, 'Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals', Tissue Barriers, vol. 4, no. 2, e1178369. https://doi.org/10.1080/21688370.2016.1178369

APA

Kristensen, M., & Nielsen, H. M. (2016). Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. Tissue Barriers, 4(2), [e1178369]. https://doi.org/10.1080/21688370.2016.1178369

Vancouver

Kristensen M, Nielsen HM. Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. Tissue Barriers. 2016;4(2). e1178369. https://doi.org/10.1080/21688370.2016.1178369

Author

Kristensen, Mie ; Nielsen, Hanne Mørck. / Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals. In: Tissue Barriers. 2016 ; Vol. 4, No. 2.

Bibtex

@article{c7dc9accc37c4c10bd7d0251bbf001b7,
title = "Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals",
abstract = "Non-injectable delivery of peptide and protein drugs is hampered by their labile nature, hydrophilicity, and large molecular size; thus limiting their permeation across mucosae, which represent major biochemical and physical barriers to drugs administered via e.g. the oral, nasal, and pulmonary routes. However, in recent years cell-penetrating peptides (CPP) have emerged as promising tools to enhance mucosal delivery of co-administered or conjugated peptide and protein cargo and more advanced CPP-cargo formulations are emerging. CPPs act as transepithelial delivery vectors, but the mechanism(s) by which CPPs mediate cargo translocation across an epithelium is so far poorly understood; both due to the fact that multiple factors influence the resulting uptake and trafficking mechanisms as well as to the complicated nature of sensitive studies of this. In addition to a proper mechanistic understanding, documentation of CPP-mediated delivery in higher animal species than rodent as well as extensive toxicological studies are necessary for CPP-containing non-injectable DDSs to reach the clinic.",
author = "Mie Kristensen and Nielsen, {Hanne M{\o}rck}",
year = "2016",
doi = "10.1080/21688370.2016.1178369",
language = "English",
volume = "4",
journal = "Tissue Barriers",
issn = "2168-8370",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals

AU - Kristensen, Mie

AU - Nielsen, Hanne Mørck

PY - 2016

Y1 - 2016

N2 - Non-injectable delivery of peptide and protein drugs is hampered by their labile nature, hydrophilicity, and large molecular size; thus limiting their permeation across mucosae, which represent major biochemical and physical barriers to drugs administered via e.g. the oral, nasal, and pulmonary routes. However, in recent years cell-penetrating peptides (CPP) have emerged as promising tools to enhance mucosal delivery of co-administered or conjugated peptide and protein cargo and more advanced CPP-cargo formulations are emerging. CPPs act as transepithelial delivery vectors, but the mechanism(s) by which CPPs mediate cargo translocation across an epithelium is so far poorly understood; both due to the fact that multiple factors influence the resulting uptake and trafficking mechanisms as well as to the complicated nature of sensitive studies of this. In addition to a proper mechanistic understanding, documentation of CPP-mediated delivery in higher animal species than rodent as well as extensive toxicological studies are necessary for CPP-containing non-injectable DDSs to reach the clinic.

AB - Non-injectable delivery of peptide and protein drugs is hampered by their labile nature, hydrophilicity, and large molecular size; thus limiting their permeation across mucosae, which represent major biochemical and physical barriers to drugs administered via e.g. the oral, nasal, and pulmonary routes. However, in recent years cell-penetrating peptides (CPP) have emerged as promising tools to enhance mucosal delivery of co-administered or conjugated peptide and protein cargo and more advanced CPP-cargo formulations are emerging. CPPs act as transepithelial delivery vectors, but the mechanism(s) by which CPPs mediate cargo translocation across an epithelium is so far poorly understood; both due to the fact that multiple factors influence the resulting uptake and trafficking mechanisms as well as to the complicated nature of sensitive studies of this. In addition to a proper mechanistic understanding, documentation of CPP-mediated delivery in higher animal species than rodent as well as extensive toxicological studies are necessary for CPP-containing non-injectable DDSs to reach the clinic.

U2 - 10.1080/21688370.2016.1178369

DO - 10.1080/21688370.2016.1178369

M3 - Review

C2 - 27358757

VL - 4

JO - Tissue Barriers

JF - Tissue Barriers

SN - 2168-8370

IS - 2

M1 - e1178369

ER -

ID: 164828215