Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa. / Stie, Mai Bay; Gätke, Johan Ring; Wan, Feng; Chronakis, Ioannis S.; Jacobsen, Jette; Nielsen, Hanne Mørck.

In: Carbohydrate Polymers, Vol. 242, 116428, 15.08.2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stie, MB, Gätke, JR, Wan, F, Chronakis, IS, Jacobsen, J & Nielsen, HM 2020, 'Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa', Carbohydrate Polymers, vol. 242, 116428. https://doi.org/10.1016/j.carbpol.2020.116428

APA

Stie, M. B., Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, J., & Nielsen, H. M. (2020). Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa. Carbohydrate Polymers, 242, [116428]. https://doi.org/10.1016/j.carbpol.2020.116428

Vancouver

Stie MB, Gätke JR, Wan F, Chronakis IS, Jacobsen J, Nielsen HM. Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa. Carbohydrate Polymers. 2020 Aug 15;242. 116428. https://doi.org/10.1016/j.carbpol.2020.116428

Author

Stie, Mai Bay ; Gätke, Johan Ring ; Wan, Feng ; Chronakis, Ioannis S. ; Jacobsen, Jette ; Nielsen, Hanne Mørck. / Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa. In: Carbohydrate Polymers. 2020 ; Vol. 242.

Bibtex

@article{70f1de1e9958448095f081dce924c529,
title = "Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa",
abstract = "Mucoadhesive chitosan-based electrospun nanofibers are promising candidates for overcoming challenges associated with sublingual drug delivery, yet studies focusing on evaluating the mucoadhesive properties of nanofibers for sublingual administration are limited. The aim was to elucidate the mucoadhesive properties of chitosan/polyethylene oxide (PEO) nanofibers focusing on how the degree of deacetylation (DDA, 53–96 %) of chitosan influenced their morphological and mucoadhesive properties. The mechanism of mucoadhesion was explained by the intermolecular interactions of chitosan with mucin from bovine submaxillary glands using quartz-crystal microbalance with dissipation monitoring and by adhesion of the nanofibers to ex vivo porcine sublingual mucosa. An increase in chitosan DDA improved the morphological stability of the nanofibers in water, but did not contribute to altered mucoadhesive properties. This study demonstrates excellent mucoadhesive properties of chitosan/PEO nanofibers and shows that the strong mucoadhesiveness of the nanofibers is attributed to their swelling ability.",
keywords = "Chitosan, Electrospun nanofibers, Mucoadhesion, Sublingual drug delivery",
author = "Stie, {Mai Bay} and G{\"a}tke, {Johan Ring} and Feng Wan and Chronakis, {Ioannis S.} and Jette Jacobsen and Nielsen, {Hanne M{\o}rck}",
year = "2020",
month = aug,
day = "15",
doi = "10.1016/j.carbpol.2020.116428",
language = "English",
volume = "242",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

AU - Stie, Mai Bay

AU - Gätke, Johan Ring

AU - Wan, Feng

AU - Chronakis, Ioannis S.

AU - Jacobsen, Jette

AU - Nielsen, Hanne Mørck

PY - 2020/8/15

Y1 - 2020/8/15

N2 - Mucoadhesive chitosan-based electrospun nanofibers are promising candidates for overcoming challenges associated with sublingual drug delivery, yet studies focusing on evaluating the mucoadhesive properties of nanofibers for sublingual administration are limited. The aim was to elucidate the mucoadhesive properties of chitosan/polyethylene oxide (PEO) nanofibers focusing on how the degree of deacetylation (DDA, 53–96 %) of chitosan influenced their morphological and mucoadhesive properties. The mechanism of mucoadhesion was explained by the intermolecular interactions of chitosan with mucin from bovine submaxillary glands using quartz-crystal microbalance with dissipation monitoring and by adhesion of the nanofibers to ex vivo porcine sublingual mucosa. An increase in chitosan DDA improved the morphological stability of the nanofibers in water, but did not contribute to altered mucoadhesive properties. This study demonstrates excellent mucoadhesive properties of chitosan/PEO nanofibers and shows that the strong mucoadhesiveness of the nanofibers is attributed to their swelling ability.

AB - Mucoadhesive chitosan-based electrospun nanofibers are promising candidates for overcoming challenges associated with sublingual drug delivery, yet studies focusing on evaluating the mucoadhesive properties of nanofibers for sublingual administration are limited. The aim was to elucidate the mucoadhesive properties of chitosan/polyethylene oxide (PEO) nanofibers focusing on how the degree of deacetylation (DDA, 53–96 %) of chitosan influenced their morphological and mucoadhesive properties. The mechanism of mucoadhesion was explained by the intermolecular interactions of chitosan with mucin from bovine submaxillary glands using quartz-crystal microbalance with dissipation monitoring and by adhesion of the nanofibers to ex vivo porcine sublingual mucosa. An increase in chitosan DDA improved the morphological stability of the nanofibers in water, but did not contribute to altered mucoadhesive properties. This study demonstrates excellent mucoadhesive properties of chitosan/PEO nanofibers and shows that the strong mucoadhesiveness of the nanofibers is attributed to their swelling ability.

KW - Chitosan

KW - Electrospun nanofibers

KW - Mucoadhesion

KW - Sublingual drug delivery

U2 - 10.1016/j.carbpol.2020.116428

DO - 10.1016/j.carbpol.2020.116428

M3 - Journal article

C2 - 32564847

VL - 242

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

M1 - 116428

ER -

ID: 243471748