Epithelial permeation and absorption mechanisms of biopharmaceuticals
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Epithelial permeation and absorption mechanisms of biopharmaceuticals. / Nielsen, Hanne Morck.
Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Vol. 9781461495246 Springer US, 2014. p. 99-122.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Epithelial permeation and absorption mechanisms of biopharmaceuticals
AU - Nielsen, Hanne Morck
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Delivery of biopharmaceuticals to local or systemic target sites via administration to mucosal surfaces is considered advantageous for several reasons, and is continuously explored by using optimized therapeutic molecules, novel excipients, and innovative formulation designs. However, the transport of biopharmaceuticals into and across epithelia in, for example, the airways and the intestine are limited due to their inherent instability and large molecular size. Thus, detailed knowledge about the properties of the epithelial barrier and the transport pathways that may be explored for delivery of peptides, proteins, and nucleotide-based drugs is a prerequisite for proper interpretation of the results of any experimental approach aiming at mucosal delivery of biopharmaceuticals. The present chapter describes the transport pathways and mechanisms relevant for epithelia in mucosal tissue providing examples of the drug delivery approaches taken to deliver biopharmaceuticals via the paracellular and/or transcellular pathways. Also, methodologies used to monitor and assess the delivery are critically discussed.
AB - Delivery of biopharmaceuticals to local or systemic target sites via administration to mucosal surfaces is considered advantageous for several reasons, and is continuously explored by using optimized therapeutic molecules, novel excipients, and innovative formulation designs. However, the transport of biopharmaceuticals into and across epithelia in, for example, the airways and the intestine are limited due to their inherent instability and large molecular size. Thus, detailed knowledge about the properties of the epithelial barrier and the transport pathways that may be explored for delivery of peptides, proteins, and nucleotide-based drugs is a prerequisite for proper interpretation of the results of any experimental approach aiming at mucosal delivery of biopharmaceuticals. The present chapter describes the transport pathways and mechanisms relevant for epithelia in mucosal tissue providing examples of the drug delivery approaches taken to deliver biopharmaceuticals via the paracellular and/or transcellular pathways. Also, methodologies used to monitor and assess the delivery are critically discussed.
KW - Analysis
KW - Complexes
KW - Lipid-based drug delivery systems
KW - Paracellular transport
KW - Particles
KW - Pathway inhibitors
KW - Permeability enhancers
KW - Polymer-based drug delivery systems
KW - Tight junction modulators
KW - Transcellular transport
KW - Transcytosis
UR - http://www.scopus.com/inward/record.url?scp=84930024302&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-9524-6_4
DO - 10.1007/978-1-4614-9524-6_4
M3 - Book chapter
AN - SCOPUS:84930024302
SN - 1461495237
SN - 9781461495239
VL - 9781461495246
SP - 99
EP - 122
BT - Mucosal Delivery of Biopharmaceuticals
PB - Springer US
ER -
ID: 239817745