Colloidal Systems in Drug Delivery
The goal of the Surface and Colloid Chemistry Group is to advance the knowledge of interactions of host defense peptides and nanomaterial carriers, with membranes and membrane components of cells and bacteria. Through this, as well as innovative approaches for performing such studies, the aim is to translate our research into further therapeutic development.
The Surface and Colloid Chemistry Group focuses its research on physicochemical aspects of drug delivery, particularly for amphiphilic host defense peptides and nanoparticulate delivery systems. For these systems, we employ a range of surface and colloid chemistry techniques, including ATR-FTIR, QCM-D, SAXS, and light scattering.
In addition, we have expanded our research to include neutron scattering, mainly neutron reflection but also SANS, e.g., for studies of the interactions of amphiphilic peptides and nanoparticulate delivery systems with model lipid membranes. Such physicochemical studies are matched with biological experiments so that key structural and dynamic issues determining the biological performance of systems can be elucidated.
“Our vision is to provide the mechanistic foundation to further the much needed development of novel peptide therapeutics in this age of emerging resistance of bacteria towards conventional antibiotics,” says Martin Malmsten.
Interaction of Laponite with Membrane Components - Consequences for Bacterial Aggregation and Infection Confinement
S. Malekkhaiat Häffner, L. Nyström, K. Browning, H. Mørck Nielsen, A. Strömstedt, M.J.A. van der Plas, A. Schmidtchen, and M. Malmsten
ACS Applied Materials Interfaces, 2019. 11,(17), 15389-15400
https://doi.org/10.1021/acsami.9b03527
Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes. Journal of Colloid and Interface Science
Parra Ortiz, Elisa; Browning, Kathryn; S. E. Damgaard, Liv Nordström, Randi; Micciulla, Samantha; Bucciarelli, Saskia; Malmsten, Martin.
Journal of Colloid and Interface Science, 2018.
https://doi.org/10.1016/j.jcis.2018.12.007
Microfluidics-based self-assembly of peptide-loaded microgels : Effect of three dimensional (3D) printed micromixer design.
Borro, Bruno C; Bohr, Adam; Bucciarelli, Saskia; Boetker, Johan P; Foged, Camilla; Rantanen, Jukka; Malmsten, Martin.
Journal of Colloid and Interface Science, Vol. 538, 07.03.2019, p. 559-568.
https://doi.org/10.1016/j.jcis.2018.12.010
Group members
Internal researchers
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