Pharmaceutical Physical and Analytical Chemistry
Universitetsparken 2, 2100 København Ø, 13, Building: 13-5-525
Primary fields of research
Scientific Focus area
Of particular interest is the possible utilization of colloidal aqueous dispersions of lipids with confined inner nanostructures (such as cubosomes, hexosomes, and micellar cubosomes) as safe and efficient drug nanocarriers. The optimal utilization of these dispersions requires studying the impact of loading drugs on their internal nanostructures, and fully comprehending the interaction of these drug-loaded dispersed particles with the biological environment to ensure the efficient transportation of the solubilized drugs. In addition, it is of our interest to address the challenges of enhancing the stability of the dispersed particles under different conditions, and of modulating their nanostructure in order to optimize their loading of different drugs.
- Cubosomes and hexosomes as drug nanocarriers
- Formation and characterization of drug nanocarriers
- Characterization of stimuli-responsive self-assembled drug nanocarriers.
- Hierarchically organized aqueous dispersions of self-assembled lipid phases: cubosomes, hexosomes, and emulsified microemulsions.
- Formulation and characterization of O/W and W/O microemulsions.
Fields of interest
Safe and efficient self-assembled drug nanocarriers
Lipid-based nano-structured drug delivery systems:
Cubosomes and hexosomes as drug nanocarriers
In situ characterization of drug formulations based on liquid crystalline phases
Current PhD students:
Shen Helvig: NANOLYMPH: NANO-engineered LYMphotropic Cubosomes and Hexosomes
The project is financed by the Danish Council for Independent Research | Technology and Production Sciences
MAX4ESSFUN grant: Co-financing 6 months SAXS experiments by the Interreg project ESS & MAX IV Cross Border Science and Society
Gizem Bor: BRAIN-PENNANO project: BRAIN PENetrating cubosomal and hexosomal NANOcarriers for glioma-targeting delivery. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences (FTP).
Mark Gontsarik: PhD project with Dr. Stefan Salentinig as main supervisor (group leader at EMPA, St. Gallen, Switzerland) based on collaboration agreement between Empa and KU
Current Master students:
Begüm Nur Ödevci
Former Postdocs and students:
Ghulam Rasool Sadat (Master student)
Raghib Ghazal (Master student)
Xianrong Shao (Master student)
Rama Prajapati (Master student)
Sabah Al-Hosayni (Master student)
Boi Vi Tran (Master student)
Umar Asghar (Master student)
Wael Alhalaq (Master student)
Firas Alturk (Master student)
Hasan Ammar Akram (Master student)
Christa Nilsson (PhD student): Cuboosmes and hexosomes as theranostic nanocarriers
Intan Diana Mat Azmi (Postdoc & PhD student):
Postdoc Project: NANO-engineered LYMphotropic Cubosomes and Hexosomes
PhD Project: Safe Cubosome and Hexosome Nanocarrier Design for Drug Delivery
The project was supported by the Staff Tranining Program (University of Puta Malaysia, UPM)
Aghiad Ghazal (Phd student): Formulation of soft self-assembled nano-pharmaceuticals (CONEXT project with Prof. Kell Mortensen)
Helene Andersen (Postdoc):NANO-engineered LYMphotropic Cubosomes and Hexosomes
Kirstin Khaliqi (Master student)
Mohammed-Jawad Tahir (Master student)
Erdal Avci (Master student)
Simon Pham (Master student)
Tadeusz Induszewski (Research assistant and Master student)
Ali Kazem (Master student)
Ömer Faruk Özdemir (Master student)
Sophie Schulha (Master student)
Selma Keceli (Master student)
Gültekin Caliskan (Master student)
Mark Gontsarik (Master student)
Sofie Fogh Hedegaard (Master student): Lipidic nanostructured aqueous dispersions as novel drug nanocarriers
Exchange/Guest student: Laura Woythe
1. INP project 2019 & 2020 (Microfluidic Platforms for Drug Delivery Applications): 217.179 kr. Co-applicant: Associate Prof. Ozlem Yesil Celiktas (Bioengineering Department, Ege University, Izmir, Turkey). A grant from the Danish Agency for Science and Higher Education for initiating and exploring new networking and collaboration opportunities between Danish and Turkish research institutions
2. BRAIN-PENNANO project 2017-2020: 2.591.817 kr. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences (FTP).
3. NANOLYMPH project 2013-2017: 5.432.056 DKK. The project is financed by the Danish Council for Independent Research | Technology and Production Sciences (Det Frie Forskningsråd for Teknologi og Produktion (FTP))
4. CoNEXT PhD project: PhD student Aghiad Ghazal
Project related to the UCPH Excellence Research Program with Kell Mortensen (Niels Bohr Institiute, Science), Susan Weng Larsen and Camilla Foged (Department of Pharmacy, Faculty of Health and Medical Sciences)
5. Danscatt: Financial support for SAXS experiments
6. Financial support for 2013-2016: 130000 DKK/year from the Ministry of Higher Education Malaysia (Intan's PhD project).
Articles with open access
Physical Chemistry, Lectures and class teaching
Physical Chemistry, Laboratory Course
Academic Awards and Honors
Årets Underviser 2011: the teacher of the Year 2011 award from the Faculty of Health and Medical Sciecnes (KU).
Lise-Meitner Fellowship (2003 & 2004) from FWF (the Austrian Science Funds).