UV imaging for in vitro dissolution and release studies: Initial experiences

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

UV imaging for in vitro dissolution and release studies: Initial experiences. / Østergaard, Jesper; Lenke, James; Jensen, Sabrine Smedegaard; Sun, Yu; Ye, Fengbin.

In: Dissolution Technologies, Vol. 21, No. 4, 2014, p. 27-38.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Østergaard, J, Lenke, J, Jensen, SS, Sun, Y & Ye, F 2014, 'UV imaging for in vitro dissolution and release studies: Initial experiences', Dissolution Technologies, vol. 21, no. 4, pp. 27-38. https://doi.org/10.14227/DT210414P27

APA

Østergaard, J., Lenke, J., Jensen, S. S., Sun, Y., & Ye, F. (2014). UV imaging for in vitro dissolution and release studies: Initial experiences. Dissolution Technologies, 21(4), 27-38. https://doi.org/10.14227/DT210414P27

Vancouver

Østergaard J, Lenke J, Jensen SS, Sun Y, Ye F. UV imaging for in vitro dissolution and release studies: Initial experiences. Dissolution Technologies. 2014;21(4):27-38. https://doi.org/10.14227/DT210414P27

Author

Østergaard, Jesper ; Lenke, James ; Jensen, Sabrine Smedegaard ; Sun, Yu ; Ye, Fengbin. / UV imaging for in vitro dissolution and release studies: Initial experiences. In: Dissolution Technologies. 2014 ; Vol. 21, No. 4. pp. 27-38.

Bibtex

@article{30868e384d5046cb967cc9f69657fd8c,
title = "UV imaging for in vitro dissolution and release studies: Initial experiences",
abstract = "UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug oncentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current strumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including etermination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.",
author = "Jesper {\O}stergaard and James Lenke and Jensen, {Sabrine Smedegaard} and Yu Sun and Fengbin Ye",
year = "2014",
doi = "10.14227/DT210414P27",
language = "English",
volume = "21",
pages = "27--38",
journal = "Dissolution Technologies",
issn = "1521-298X",
publisher = "Dissolution Technologies, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - UV imaging for in vitro dissolution and release studies: Initial experiences

AU - Østergaard, Jesper

AU - Lenke, James

AU - Jensen, Sabrine Smedegaard

AU - Sun, Yu

AU - Ye, Fengbin

PY - 2014

Y1 - 2014

N2 - UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug oncentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current strumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including etermination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.

AB - UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug oncentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current strumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including etermination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.

U2 - 10.14227/DT210414P27

DO - 10.14227/DT210414P27

M3 - Journal article

VL - 21

SP - 27

EP - 38

JO - Dissolution Technologies

JF - Dissolution Technologies

SN - 1521-298X

IS - 4

ER -

ID: 137599207