TY - JOUR

T1 - Using ion-selective electrodes to study the drug release from porous cellulose matrices

AU - Vakili, Hossein

AU - Genina, Natalja

AU - Ehlers, Henrik

AU - Bobacka, Johan

AU - Sandler, Niklas

PY - 2012

Y1 - 2012

N2 - Polyvinyl chloride (PVC)-based solid-contact ion-selective electrodes \r\n(SC-ISEs), responding to propranolol hydrochloride (Pr+) and lidocaine hydrochloride (Ld+) cations as the model drugs with potassium tetrakis(4-chlorophenyl) borate (KTpClPB) as the ion exchanger, were studied. Different drug-polymer solutions were prepared with the model drugs, using different blend ratios of ethylcellulose (EC) and hydroxypropyl cellulose (HPC). Two different solid dosage forms were used. Polymer films were produced by solvent casting method and drug containing porous cellulose samples were prepared by depositing the drug-polymer solutions onto filter paper substrates. The quality of the electrodes and the release profile of Pr+ and Ld+ were investigated with \r\nthe potentiometric method. The results were compared to UV spectrophotometry. The electrodes were found to be sensitive, precise and functional with a Nernstian behavior over the range of 1.0 × 10−3–3.1 × 10−6 M (9.2 × 10−4–3.0 × 10−1 mg/mL) and \r\n1 × 10−3–2 × 10−6 M (5.4 × 10−4–2.7 × 10−1 mg/mL) at 25 °C for Pr+ and Ld+ sensitive electrodes, respectively. The dynamic response time for the electrodes was less than 10 s. The Pr+ release from porous filter paper was always higher than its equivalent film formulation. Also, lidocaine had higher and faster release from the samples with higher drug concentration. The comparison of the two analytical methods showed near \r\nidentical results. The ISEs provided a powerful and flexible alternative to UV method \r\nin determination of drug release from porous cellulose substrates in a small scale \r\ndissolution testing.

AB - Polyvinyl chloride (PVC)-based solid-contact ion-selective electrodes \r\n(SC-ISEs), responding to propranolol hydrochloride (Pr+) and lidocaine hydrochloride (Ld+) cations as the model drugs with potassium tetrakis(4-chlorophenyl) borate (KTpClPB) as the ion exchanger, were studied. Different drug-polymer solutions were prepared with the model drugs, using different blend ratios of ethylcellulose (EC) and hydroxypropyl cellulose (HPC). Two different solid dosage forms were used. Polymer films were produced by solvent casting method and drug containing porous cellulose samples were prepared by depositing the drug-polymer solutions onto filter paper substrates. The quality of the electrodes and the release profile of Pr+ and Ld+ were investigated with \r\nthe potentiometric method. The results were compared to UV spectrophotometry. The electrodes were found to be sensitive, precise and functional with a Nernstian behavior over the range of 1.0 × 10−3–3.1 × 10−6 M (9.2 × 10−4–3.0 × 10−1 mg/mL) and \r\n1 × 10−3–2 × 10−6 M (5.4 × 10−4–2.7 × 10−1 mg/mL) at 25 °C for Pr+ and Ld+ sensitive electrodes, respectively. The dynamic response time for the electrodes was less than 10 s. The Pr+ release from porous filter paper was always higher than its equivalent film formulation. Also, lidocaine had higher and faster release from the samples with higher drug concentration. The comparison of the two analytical methods showed near \r\nidentical results. The ISEs provided a powerful and flexible alternative to UV method \r\nin determination of drug release from porous cellulose substrates in a small scale \r\ndissolution testing.

KW - Ion-selective electrodes

KW - Lidocaine hydrochloride

KW - Polymer film

KW - Porous substrates

KW - Potentiometry

KW - Propranolol hydrochloride

KW - UV spectrophotometry

U2 - 10.3390/pharmaceutics4030366

DO - 10.3390/pharmaceutics4030366

M3 - Journal article

C2 - 24300297

VL - 4

SP - 366

EP - 376

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 3

ER -