Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation
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Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation. / Rawle, Chris B; Lee, Chris J; Strachan, Clare J; Payne, Keith; Manson, Peter J; Rades, Thomas.
In: Journal of Pharmaceutical Sciences, Vol. 95, No. 4, 2006, p. 761-8.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation
AU - Rawle, Chris B
AU - Lee, Chris J
AU - Strachan, Clare J
AU - Payne, Keith
AU - Manson, Peter J
AU - Rades, Thomas
PY - 2006
Y1 - 2006
N2 - In this paper, we report improvements to a previously developed method based on optical nonlinearity for characterizing polymorphism and concentration of pharmaceuticals in powdered and tablet form. An apparatus that measures the nonlinear optical response of a sample through second harmonic generation (SHG) is described. The response of several enalapril maleate-polyvinylpyrrolidone (PVP) tablets was measured, the results of which were used to determine the concentration of the drug. The current limit of detection of the apparatus was found to be approximately 1%-2%. Ranitidine hydrochloride (RN) polymorph forms I and II were also characterized using SHG. It was found that pure samples of forms I and II could be clearly and rapidly distinguished. Mixtures consisting of 50% form I and 50% form II were also distinguishable from the respective pure forms. An investigation was performed into the size dependence of the SHG response for crystalline lactose. It was found that the SHG response was a slowly decreasing monotonic function of particle size. Additional investigation into the angular dependence of the scattered SHG light was also undertaken for crystalline lactose. This new technique based on optical nonlinearity offers promise for application in monitoring of pharmaceutical manufacturing processes.
AB - In this paper, we report improvements to a previously developed method based on optical nonlinearity for characterizing polymorphism and concentration of pharmaceuticals in powdered and tablet form. An apparatus that measures the nonlinear optical response of a sample through second harmonic generation (SHG) is described. The response of several enalapril maleate-polyvinylpyrrolidone (PVP) tablets was measured, the results of which were used to determine the concentration of the drug. The current limit of detection of the apparatus was found to be approximately 1%-2%. Ranitidine hydrochloride (RN) polymorph forms I and II were also characterized using SHG. It was found that pure samples of forms I and II could be clearly and rapidly distinguished. Mixtures consisting of 50% form I and 50% form II were also distinguishable from the respective pure forms. An investigation was performed into the size dependence of the SHG response for crystalline lactose. It was found that the SHG response was a slowly decreasing monotonic function of particle size. Additional investigation into the angular dependence of the scattered SHG light was also undertaken for crystalline lactose. This new technique based on optical nonlinearity offers promise for application in monitoring of pharmaceutical manufacturing processes.
U2 - 10.1002/jps.20575
DO - 10.1002/jps.20575
M3 - Journal article
C2 - 16498571
VL - 95
SP - 761
EP - 768
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 4
ER -
ID: 40357558