Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation

Research output: Contribution to journalJournal articlepeer-review

Standard

Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation. / Rawle, Chris B; Lee, Chris J; Strachan, Clare J; Payne, Keith; Manson, Peter J; Rades, Thomas.

In: Journal of Pharmaceutical Sciences, Vol. 95, No. 4, 2006, p. 761-8.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rawle, CB, Lee, CJ, Strachan, CJ, Payne, K, Manson, PJ & Rades, T 2006, 'Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation', Journal of Pharmaceutical Sciences, vol. 95, no. 4, pp. 761-8. https://doi.org/10.1002/jps.20575

APA

Rawle, C. B., Lee, C. J., Strachan, C. J., Payne, K., Manson, P. J., & Rades, T. (2006). Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation. Journal of Pharmaceutical Sciences, 95(4), 761-8. https://doi.org/10.1002/jps.20575

Vancouver

Rawle CB, Lee CJ, Strachan CJ, Payne K, Manson PJ, Rades T. Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation. Journal of Pharmaceutical Sciences. 2006;95(4):761-8. https://doi.org/10.1002/jps.20575

Author

Rawle, Chris B ; Lee, Chris J ; Strachan, Clare J ; Payne, Keith ; Manson, Peter J ; Rades, Thomas. / Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation. In: Journal of Pharmaceutical Sciences. 2006 ; Vol. 95, No. 4. pp. 761-8.

Bibtex

@article{d1bdabcba0f041ffab3b3ce3ad6e219b,
title = "Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation",
abstract = "In this paper, we report improvements to a previously developed method based on optical nonlinearity for characterizing polymorphism and concentration of pharmaceuticals in powdered and tablet form. An apparatus that measures the nonlinear optical response of a sample through second harmonic generation (SHG) is described. The response of several enalapril maleate-polyvinylpyrrolidone (PVP) tablets was measured, the results of which were used to determine the concentration of the drug. The current limit of detection of the apparatus was found to be approximately 1%-2%. Ranitidine hydrochloride (RN) polymorph forms I and II were also characterized using SHG. It was found that pure samples of forms I and II could be clearly and rapidly distinguished. Mixtures consisting of 50% form I and 50% form II were also distinguishable from the respective pure forms. An investigation was performed into the size dependence of the SHG response for crystalline lactose. It was found that the SHG response was a slowly decreasing monotonic function of particle size. Additional investigation into the angular dependence of the scattered SHG light was also undertaken for crystalline lactose. This new technique based on optical nonlinearity offers promise for application in monitoring of pharmaceutical manufacturing processes.",
author = "Rawle, {Chris B} and Lee, {Chris J} and Strachan, {Clare J} and Keith Payne and Manson, {Peter J} and Thomas Rades",
year = "2006",
doi = "10.1002/jps.20575",
language = "English",
volume = "95",
pages = "761--8",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Towards characterization and identification of solid state pharmaceutical mixtures through second harmonic generation

AU - Rawle, Chris B

AU - Lee, Chris J

AU - Strachan, Clare J

AU - Payne, Keith

AU - Manson, Peter J

AU - Rades, Thomas

PY - 2006

Y1 - 2006

N2 - In this paper, we report improvements to a previously developed method based on optical nonlinearity for characterizing polymorphism and concentration of pharmaceuticals in powdered and tablet form. An apparatus that measures the nonlinear optical response of a sample through second harmonic generation (SHG) is described. The response of several enalapril maleate-polyvinylpyrrolidone (PVP) tablets was measured, the results of which were used to determine the concentration of the drug. The current limit of detection of the apparatus was found to be approximately 1%-2%. Ranitidine hydrochloride (RN) polymorph forms I and II were also characterized using SHG. It was found that pure samples of forms I and II could be clearly and rapidly distinguished. Mixtures consisting of 50% form I and 50% form II were also distinguishable from the respective pure forms. An investigation was performed into the size dependence of the SHG response for crystalline lactose. It was found that the SHG response was a slowly decreasing monotonic function of particle size. Additional investigation into the angular dependence of the scattered SHG light was also undertaken for crystalline lactose. This new technique based on optical nonlinearity offers promise for application in monitoring of pharmaceutical manufacturing processes.

AB - In this paper, we report improvements to a previously developed method based on optical nonlinearity for characterizing polymorphism and concentration of pharmaceuticals in powdered and tablet form. An apparatus that measures the nonlinear optical response of a sample through second harmonic generation (SHG) is described. The response of several enalapril maleate-polyvinylpyrrolidone (PVP) tablets was measured, the results of which were used to determine the concentration of the drug. The current limit of detection of the apparatus was found to be approximately 1%-2%. Ranitidine hydrochloride (RN) polymorph forms I and II were also characterized using SHG. It was found that pure samples of forms I and II could be clearly and rapidly distinguished. Mixtures consisting of 50% form I and 50% form II were also distinguishable from the respective pure forms. An investigation was performed into the size dependence of the SHG response for crystalline lactose. It was found that the SHG response was a slowly decreasing monotonic function of particle size. Additional investigation into the angular dependence of the scattered SHG light was also undertaken for crystalline lactose. This new technique based on optical nonlinearity offers promise for application in monitoring of pharmaceutical manufacturing processes.

U2 - 10.1002/jps.20575

DO - 10.1002/jps.20575

M3 - Journal article

C2 - 16498571

VL - 95

SP - 761

EP - 768

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 4

ER -

ID: 40357558