Thiol-responsive lyotropic liquid crystals exhibit triggered phase re-arrangement and hydrogen sulfide (H2S) release
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Accepted author manuscript, 393 KB, PDF document
Hydrogen sulfide (H2S) is an important signalling molecule with potential pharmaceutical applications. In pursuit of a suitable delivery system for H2S, herein we apply an amphiphilic trisulfide to concomitantly alter the mesophase behaviour of dispersed lipid particles and enable triggered H2S release. Amperometric release studies indicate the trisulfide acts as a sustained H2S donor, with inclusion into the mesophase attenuating release vs neat dispersed trisulfide. Taken together the results highlight the potential for including trisulfide-based additives in stimuli-responsive drug delivery vehicles.
| Original language | English |
|---|---|
| Journal | Journal of Colloid and Interface Science |
| Volume | 613 |
| Pages (from-to) | 218-223 |
| ISSN | 0021-9797 |
| DOIs | |
| Publication status | Published - 2022 |
Bibliographical note
Funding Information:
This work was carried out within the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036). J. F. Q. is grateful for an ARC Future Fellowship (FT170100144). The small angle X-ray scattering studies described herein were performed on the SAXS/WAXS beamline at the Australian Synchrotron, part of ANSTO. The authors acknowledge support provided to this project from the Australian Synchrotron (Australian Synchrotron Beamtime Application AS2/SAXS/16144). We also wish to acknowledge support provided to this research project by the HMSTrust Analytical Laboratory which is based at the Monash Institute of Pharmaceutical Sciences.
Funding Information:
This work was carried out within the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036). J. F. Q. is grateful for an ARC Future Fellowship (FT170100144). The small angle X-ray scattering studies described herein were performed on the SAXS/WAXS beamline at the Australian Synchrotron, part of ANSTO. The authors acknowledge support provided to this project from the Australian Synchrotron (Australian Synchrotron Beamtime Application AS2/SAXS/16144). We also wish to acknowledge support provided to this research project by the HMSTrust Analytical Laboratory which is based at the Monash Institute of Pharmaceutical Sciences.
Publisher Copyright:
© 2022 Elsevier Inc.
- Drug delivery, Hydrogen sulfide, Liquid crystal nanoparticles, Self assembly, Trisulfide
Research areas
ID: 291739122