Thin-coating as an alternative approach to improve flow properties of ibuprofen powder.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Thin-coating as an alternative approach to improve flow properties of ibuprofen powder. / Genina, Natalja; Räikkönen, Heikki; Ehlers, Henrik; Heinämäki, Jyrki; Veski, Peep; Yliruusi, Jouko.

In: International Journal of Pharmaceutics, 15.03.2010, p. 65-70.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Genina, N, Räikkönen, H, Ehlers, H, Heinämäki, J, Veski, P & Yliruusi, J 2010, 'Thin-coating as an alternative approach to improve flow properties of ibuprofen powder.', International Journal of Pharmaceutics, pp. 65-70. https://doi.org/10.1016/j.ijpharm.2009.12.005

APA

Genina, N., Räikkönen, H., Ehlers, H., Heinämäki, J., Veski, P., & Yliruusi, J. (2010). Thin-coating as an alternative approach to improve flow properties of ibuprofen powder. International Journal of Pharmaceutics, 65-70. https://doi.org/10.1016/j.ijpharm.2009.12.005

Vancouver

Genina N, Räikkönen H, Ehlers H, Heinämäki J, Veski P, Yliruusi J. Thin-coating as an alternative approach to improve flow properties of ibuprofen powder. International Journal of Pharmaceutics. 2010 Mar 15;65-70. https://doi.org/10.1016/j.ijpharm.2009.12.005

Author

Genina, Natalja ; Räikkönen, Heikki ; Ehlers, Henrik ; Heinämäki, Jyrki ; Veski, Peep ; Yliruusi, Jouko. / Thin-coating as an alternative approach to improve flow properties of ibuprofen powder. In: International Journal of Pharmaceutics. 2010 ; pp. 65-70.

Bibtex

@article{bb41ed1cdc324364a7fea39ad381f735,
title = "Thin-coating as an alternative approach to improve flow properties of ibuprofen powder.",
abstract = "In the present study, thin-coating as a potential method for improving flow properties of cohesive ibuprofen powder was introduced. Briefly, the technique was based on the successive deposition of ultrasound-assisted fine polymer mist onto the surface of the powdered active pharmaceutical ingredient (API), producing individual particles with a hydrophilic thin-coat. A 0.15% m/V aqueous solution of hydroxypropyl methylcellulose (HPMC) was used. Particle size and surface analysis revealed a decrease in the cohesiveness of ibuprofen powder and an increase in the homogeneity of particle surfaces as a result of polymer treatment. Superficial changes caused a substantial improvement on the flowing characteristics of coated substance over uncoated. The enhancement in flow rate proceeded as the uniformity of the HPMC layer increased. In conclusion, the proposed technique is a simple and effective method that can be used as a continuous process to modify API particle surface properties, which in turn improve the handling of poorly flowable powder.",
keywords = "Chemistry, Pharmaceutical, Chemistry, Pharmaceutical: methods, Excipients, Excipients: chemistry, Ibuprofen, Ibuprofen: chemistry, Methylcellulose, Methylcellulose: analogs & derivatives, Methylcellulose: chemistry, Particle Size, Powders, Surface Properties, Technology, Pharmaceutical, Technology, Pharmaceutical: methods, Ultrasonics",
author = "Natalja Genina and Heikki R{\"a}ikk{\"o}nen and Henrik Ehlers and Jyrki Hein{\"a}m{\"a}ki and Peep Veski and Jouko Yliruusi",
year = "2010",
month = mar,
day = "15",
doi = "10.1016/j.ijpharm.2009.12.005",
language = "English",
pages = "65--70",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Thin-coating as an alternative approach to improve flow properties of ibuprofen powder.

AU - Genina, Natalja

AU - Räikkönen, Heikki

AU - Ehlers, Henrik

AU - Heinämäki, Jyrki

AU - Veski, Peep

AU - Yliruusi, Jouko

PY - 2010/3/15

Y1 - 2010/3/15

N2 - In the present study, thin-coating as a potential method for improving flow properties of cohesive ibuprofen powder was introduced. Briefly, the technique was based on the successive deposition of ultrasound-assisted fine polymer mist onto the surface of the powdered active pharmaceutical ingredient (API), producing individual particles with a hydrophilic thin-coat. A 0.15% m/V aqueous solution of hydroxypropyl methylcellulose (HPMC) was used. Particle size and surface analysis revealed a decrease in the cohesiveness of ibuprofen powder and an increase in the homogeneity of particle surfaces as a result of polymer treatment. Superficial changes caused a substantial improvement on the flowing characteristics of coated substance over uncoated. The enhancement in flow rate proceeded as the uniformity of the HPMC layer increased. In conclusion, the proposed technique is a simple and effective method that can be used as a continuous process to modify API particle surface properties, which in turn improve the handling of poorly flowable powder.

AB - In the present study, thin-coating as a potential method for improving flow properties of cohesive ibuprofen powder was introduced. Briefly, the technique was based on the successive deposition of ultrasound-assisted fine polymer mist onto the surface of the powdered active pharmaceutical ingredient (API), producing individual particles with a hydrophilic thin-coat. A 0.15% m/V aqueous solution of hydroxypropyl methylcellulose (HPMC) was used. Particle size and surface analysis revealed a decrease in the cohesiveness of ibuprofen powder and an increase in the homogeneity of particle surfaces as a result of polymer treatment. Superficial changes caused a substantial improvement on the flowing characteristics of coated substance over uncoated. The enhancement in flow rate proceeded as the uniformity of the HPMC layer increased. In conclusion, the proposed technique is a simple and effective method that can be used as a continuous process to modify API particle surface properties, which in turn improve the handling of poorly flowable powder.

KW - Chemistry, Pharmaceutical

KW - Chemistry, Pharmaceutical: methods

KW - Excipients

KW - Excipients: chemistry

KW - Ibuprofen

KW - Ibuprofen: chemistry

KW - Methylcellulose

KW - Methylcellulose: analogs & derivatives

KW - Methylcellulose: chemistry

KW - Particle Size

KW - Powders

KW - Surface Properties

KW - Technology, Pharmaceutical

KW - Technology, Pharmaceutical: methods

KW - Ultrasonics

U2 - 10.1016/j.ijpharm.2009.12.005

DO - 10.1016/j.ijpharm.2009.12.005

M3 - Journal article

C2 - 20005929

SP - 65

EP - 70

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

ER -

ID: 145539769