Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine

Research output: Contribution to journal › Journal article › Research › peer-review

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Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine. / Xu, Xiaoyue; Rades, Thomas; Grohganz, Holger.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 186, 2023, p. 1-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xu, X, Rades, T & Grohganz, H 2023, 'Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine', European Journal of Pharmaceutics and Biopharmaceutics, vol. 186, pp. 1-6. https://doi.org/10.1016/j.ejpb.2023.02.015

APA

Xu, X., Rades, T., & Grohganz, H. (2023). Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine. European Journal of Pharmaceutics and Biopharmaceutics, 186, 1-6. https://doi.org/10.1016/j.ejpb.2023.02.015

Vancouver

Xu X, Rades T, Grohganz H. Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine. European Journal of Pharmaceutics and Biopharmaceutics. 2023;186:1-6. https://doi.org/10.1016/j.ejpb.2023.02.015

Author

Xu, Xiaoyue ; Rades, Thomas ; Grohganz, Holger. / Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine. In: European Journal of Pharmaceutics and Biopharmaceutics. 2023 ; Vol. 186. pp. 1-6.

Bibtex

@article{bde4ac2452a74fec8d11c4c450db7e8f,

title = "Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine",

abstract = "It is generally recognized that water, acting as a plasticizer, increases molecular mobility, leading to a decrease of the glass transition temperature (Tg) in amorphous systems. However, an anti-plasticizing effect of water was recently observed on prilocaine (PRL). This effect might be used in co-amorphous systems to moderate the plasticizing effect of water. Nicotinamide (NIC) can form co-amorphous systems with PRL. In order to investigate the effect of water on these co-amorphous systems, the Tgs and molecular mobility of hydrated co-amorphous NIC-PRL systems were compared with those of the respective anhydrous systems. Molecular mobility was estimated by considering the enthalpic recovery at the Tg using the Kohlrausch-Williams-Watts (KWW) equation. At molar ratios of NIC above 0.2, a plasticizing effect of water on co-amorphous NIC-PRL systems was observed with increasing the NIC concentration. In contrast, at molar ratios of NIC of 0.2 and below, water had an anti-plasticizing effect on the co-amorphous NIC-PRL systems, with increased Tgs and reduced mobility upon hydration.",

keywords = "Anti-plasticizing effect of water, Co-amorphous, Glass transition, Molecular mobility, Prilocaine-nicotinamide",

author = "Xiaoyue Xu and Thomas Rades and Holger Grohganz",

note = "Funding Information: Xiaoyue Xu acknowledges the China Scholarship Council (Grant 202008420212) for financial support. Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

doi = "10.1016/j.ejpb.2023.02.015",

language = "English",

volume = "186",

pages = "1--6",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine

AU - Xu, Xiaoyue

AU - Rades, Thomas

AU - Grohganz, Holger

PY - 2023

Y1 - 2023

N2 - It is generally recognized that water, acting as a plasticizer, increases molecular mobility, leading to a decrease of the glass transition temperature (Tg) in amorphous systems. However, an anti-plasticizing effect of water was recently observed on prilocaine (PRL). This effect might be used in co-amorphous systems to moderate the plasticizing effect of water. Nicotinamide (NIC) can form co-amorphous systems with PRL. In order to investigate the effect of water on these co-amorphous systems, the Tgs and molecular mobility of hydrated co-amorphous NIC-PRL systems were compared with those of the respective anhydrous systems. Molecular mobility was estimated by considering the enthalpic recovery at the Tg using the Kohlrausch-Williams-Watts (KWW) equation. At molar ratios of NIC above 0.2, a plasticizing effect of water on co-amorphous NIC-PRL systems was observed with increasing the NIC concentration. In contrast, at molar ratios of NIC of 0.2 and below, water had an anti-plasticizing effect on the co-amorphous NIC-PRL systems, with increased Tgs and reduced mobility upon hydration.

AB - It is generally recognized that water, acting as a plasticizer, increases molecular mobility, leading to a decrease of the glass transition temperature (Tg) in amorphous systems. However, an anti-plasticizing effect of water was recently observed on prilocaine (PRL). This effect might be used in co-amorphous systems to moderate the plasticizing effect of water. Nicotinamide (NIC) can form co-amorphous systems with PRL. In order to investigate the effect of water on these co-amorphous systems, the Tgs and molecular mobility of hydrated co-amorphous NIC-PRL systems were compared with those of the respective anhydrous systems. Molecular mobility was estimated by considering the enthalpic recovery at the Tg using the Kohlrausch-Williams-Watts (KWW) equation. At molar ratios of NIC above 0.2, a plasticizing effect of water on co-amorphous NIC-PRL systems was observed with increasing the NIC concentration. In contrast, at molar ratios of NIC of 0.2 and below, water had an anti-plasticizing effect on the co-amorphous NIC-PRL systems, with increased Tgs and reduced mobility upon hydration.

KW - Anti-plasticizing effect of water

KW - Co-amorphous

KW - Glass transition

KW - Molecular mobility

KW - Prilocaine-nicotinamide

U2 - 10.1016/j.ejpb.2023.02.015

DO - 10.1016/j.ejpb.2023.02.015

M3 - Journal article

C2 - 36878408

AN - SCOPUS:85150066373

VL - 186

SP - 1

EP - 6

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -

ID: 341261281

Department of Pharmacy