Thermal degradation of amorphous glibenclamide

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A glibenclamide polymorph published by Panagopoulou-Kaplani and Malamataris (2000) [1], obtained by sublimation of amorphous glibenclamide, was analysed. A new interpretation of the data is presented and experimentally confirmed by X-ray powder diffractometry, Fourier transformation infrared spectroscopy, differential scanning calorimetry, and mass spectrometry. The crystals formed during sublimation of amorphous glibenclamide do not represent a glibenclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea. The reaction mechanism is suggested to be an elimination of cyclohexylisocyanate from glibenclamide. Cyclohexylisocyanate may decompose to carbon monoxide and cyclohexylamine, which may react in an addition reaction with another cyclohexylisocyanate molecule forming 1,3-dicyclohexylurea.

Original languageEnglish
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Issue number1
Pages (from-to)203-208
Number of pages6
Publication statusPublished - Jan 2012

    Research areas

  • 1,3-Dicyclohexylurea, Amorphous, Glibenclamide, Polymorphism, Thermal degradation

ID: 299416082