Theoretical Considerations in Developing Amorphous Solid Dispersions
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Theoretical Considerations in Developing Amorphous Solid Dispersions. / Laitinen, Riikka; Priemel, Petra Alexandra; Surwase, Sachin; Graeser, Kirsten; Strachan, Clare J.; Grohganz, Holger; Rades, Thomas.
Amorphous Solid Dispersions - Theory and Practice. ed. / Navnit Shah; Harpreet Sandhu; Duk Soon Choi; Hitesh Chokshi; A. Waseem Malick. New York : Springer Science+Business Media, 2014. p. 35-90.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Theoretical Considerations in Developing Amorphous Solid Dispersions
AU - Laitinen, Riikka
AU - Priemel, Petra Alexandra
AU - Surwase, Sachin
AU - Graeser, Kirsten
AU - Strachan, Clare J.
AU - Grohganz, Holger
AU - Rades, Thomas
PY - 2014
Y1 - 2014
N2 - Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in bioavailability, can be expected, and what forms of solid dispersion have been developed in the past. In this chapter, we therefore initially define the various forms of solid dispersions, and then go on to discuss properties of pure drugs with respect to their glass-forming ability and glass stability. In the main parts of this chapter, we review theoretical approaches to determine amorphous drug polymer miscibility and crystalline drug polymer solubility, as a prerequisite to develop amorphous solid dispersions (glass solutions).
AB - Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is the topic of many of the subsequent chapters in this book, the formulation scientist would benefit from a priori knowledge whether the amorphous route is a viable one for a given drug and how much solubility improvement, and hence increase in bioavailability, can be expected, and what forms of solid dispersion have been developed in the past. In this chapter, we therefore initially define the various forms of solid dispersions, and then go on to discuss properties of pure drugs with respect to their glass-forming ability and glass stability. In the main parts of this chapter, we review theoretical approaches to determine amorphous drug polymer miscibility and crystalline drug polymer solubility, as a prerequisite to develop amorphous solid dispersions (glass solutions).
U2 - 10.1007/978-1-4939-1598-9_2
DO - 10.1007/978-1-4939-1598-9_2
M3 - Book chapter
SN - 978-1-4939-1597-2
SP - 35
EP - 90
BT - Amorphous Solid Dispersions - Theory and Practice
A2 - Shah, Navnit
A2 - Sandhu, Harpreet
A2 - Choi, Duk Soon
A2 - Chokshi, Hitesh
A2 - Malick, A. Waseem
PB - Springer Science+Business Media
CY - New York
ER -
ID: 138134516