The effects of surfactants on the performance of polymer-based microwave-induced in situ amorphization
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Microwave-induced in situ amorphization is a novel technology for preparing amorphous solid dispersions (ASDs) to address the challenges of their long-term physical stability and downstream processing. To date, only few types of dielectric materials have been reported for microwave-induced in situ amorphization, which restricted the extensive research of this technology. This study aimed to investigate the feasibility and mechanisms of utilizing the non-ionic surfactants, i.e. Kollisolv P124, Kolliphor RH40, D-ɑ-tocopheryl polyethylene glycol succinate (TPGS), Tween (T) 60 (T60), T65, T80 and T85, as plasticizers to facilitate microwave-induced in situ amorphization. It was found that the successful application of surfactants could be related with their low Tm, low Mw and high HLB. Kolliphor RH40 was selected as a typical surfactant due to its excellent dielectric heating ability, plasticizing effect and solubilizing effect when facilitating amorphization. Then, the dissolution-mediated in situ amorphization mechanism was investigated and intuitively demonstrated. For the most promising formulation, i.e. microwaved systems with Korlliphor RH40 at 1.5 (w/w) plasticizer/polymer ratio, a complete and fast in vitro dissolution was observed relative to the untreated systems. In conclusion, non-ionic surfactants had the potential to facilitate microwave-induced in situ amorphization, which provided a new direction in the formulation designation for microwave-able systems.
Original language | English |
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Article number | 122426 |
Journal | International Journal of Pharmaceutics |
Volume | 630 |
Number of pages | 17 |
ISSN | 0378-5173 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:
The project was supported by Queen's University Belfast/Chinese Scholarship Council (CSC) scholarship (CSC NO. 201806370231).
Publisher Copyright:
© 2022
- Amorphous solid dispersion, In situ amorphization, Microwave, Plasticizer, Surfactant
Research areas
ID: 332996739