The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin: III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin : III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis. / Songkro, S.; Becket, G.; Rades, T.

In: Journal of Drug Delivery Science and Technology, Vol. 14, No. 3, 2004, p. 223-228.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Songkro, S, Becket, G & Rades, T 2004, 'The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin: III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis', Journal of Drug Delivery Science and Technology, vol. 14, no. 3, pp. 223-228. https://doi.org/10.1016/s1773-2247(04)50104-1

APA

Songkro, S., Becket, G., & Rades, T. (2004). The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin: III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis. Journal of Drug Delivery Science and Technology, 14(3), 223-228. https://doi.org/10.1016/s1773-2247(04)50104-1

Vancouver

Songkro S, Becket G, Rades T. The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin: III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis. Journal of Drug Delivery Science and Technology. 2004;14(3):223-228. https://doi.org/10.1016/s1773-2247(04)50104-1

Author

Songkro, S. ; Becket, G. ; Rades, T. / The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin : III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis. In: Journal of Drug Delivery Science and Technology. 2004 ; Vol. 14, No. 3. pp. 223-228.

Bibtex

@article{dc03dacc1a1f49279a4d76f2260ca642,
title = "The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin: III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis",
abstract = "Principal components analysis (PCA) and multivariate regression analysis have been employed to study the relationship between a series of calculated physicochemical properties of terpenes (solubility parameter, calculated logKoct, molecular mass, molecular volume, calculated surface tension, scaled H-bonding donor and acceptor values, non-carbonyl carbons per molecule) to the permeation enhancing activity of each terpene for propranolol HCl across newborn pig skin. With PCA, a smaller number of new variables (five principal components) were used as predictors in regression analysis in order to predict the enhancing activity of terpenes on the permeation of the model drug propranolol HCl. A fairly high coefficient of determination (R2 = 0.87) suggested that the resultant regression equation was able to adequately predict trends in the enhancing activity of the terpenes. PCA results suggested the importance of a combination of the physicochemical properties on the enhancing activities of the terpenes. A suitable balance between these terpene properties is required to lead to a considerable enhancement of propranolol HCl penetration.",
keywords = "Percutaneous absorption, Physicochemical properties, Principal components analysis, Propranolol HCl, Terpenes",
author = "S. Songkro and G. Becket and T. Rades",
year = "2004",
doi = "10.1016/s1773-2247(04)50104-1",
language = "English",
volume = "14",
pages = "223--228",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - The effects of p-menthane monoterpenes and related compounds on the percutaneous absorption of propranolol hydrochloride across newborn pig skin

T2 - III. Correlation between penetration enhancing activity and physicochemical properties of terpenes determined by principal components analysis

AU - Songkro, S.

AU - Becket, G.

AU - Rades, T.

PY - 2004

Y1 - 2004

N2 - Principal components analysis (PCA) and multivariate regression analysis have been employed to study the relationship between a series of calculated physicochemical properties of terpenes (solubility parameter, calculated logKoct, molecular mass, molecular volume, calculated surface tension, scaled H-bonding donor and acceptor values, non-carbonyl carbons per molecule) to the permeation enhancing activity of each terpene for propranolol HCl across newborn pig skin. With PCA, a smaller number of new variables (five principal components) were used as predictors in regression analysis in order to predict the enhancing activity of terpenes on the permeation of the model drug propranolol HCl. A fairly high coefficient of determination (R2 = 0.87) suggested that the resultant regression equation was able to adequately predict trends in the enhancing activity of the terpenes. PCA results suggested the importance of a combination of the physicochemical properties on the enhancing activities of the terpenes. A suitable balance between these terpene properties is required to lead to a considerable enhancement of propranolol HCl penetration.

AB - Principal components analysis (PCA) and multivariate regression analysis have been employed to study the relationship between a series of calculated physicochemical properties of terpenes (solubility parameter, calculated logKoct, molecular mass, molecular volume, calculated surface tension, scaled H-bonding donor and acceptor values, non-carbonyl carbons per molecule) to the permeation enhancing activity of each terpene for propranolol HCl across newborn pig skin. With PCA, a smaller number of new variables (five principal components) were used as predictors in regression analysis in order to predict the enhancing activity of terpenes on the permeation of the model drug propranolol HCl. A fairly high coefficient of determination (R2 = 0.87) suggested that the resultant regression equation was able to adequately predict trends in the enhancing activity of the terpenes. PCA results suggested the importance of a combination of the physicochemical properties on the enhancing activities of the terpenes. A suitable balance between these terpene properties is required to lead to a considerable enhancement of propranolol HCl penetration.

KW - Percutaneous absorption

KW - Physicochemical properties

KW - Principal components analysis

KW - Propranolol HCl

KW - Terpenes

UR - http://www.scopus.com/inward/record.url?scp=2942729929&partnerID=8YFLogxK

U2 - 10.1016/s1773-2247(04)50104-1

DO - 10.1016/s1773-2247(04)50104-1

M3 - Journal article

AN - SCOPUS:2942729929

VL - 14

SP - 223

EP - 228

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

IS - 3

ER -

ID: 299428409