The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro

Research output: Contribution to journal › Journal article › Research › peer-review

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The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro. / Aho, Johanna; Halme, Amanda; Boetker, Johan; Water, Jorrit Jeroen; Bohr, Adam; Sandler, Niklas; Rantanen, Jukka; Baldursdottir, Stefania.

In: Carbohydrate Polymers, Vol. 177, 01.12.2017, p. 433-442.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Aho, J, Halme, A, Boetker, J, Water, JJ, Bohr, A, Sandler, N, Rantanen, J & Baldursdottir, S 2017, 'The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro', Carbohydrate Polymers, vol. 177, pp. 433-442. https://doi.org/10.1016/j.carbpol.2017.08.135

APA

Aho, J., Halme, A., Boetker, J., Water, J. J., Bohr, A., Sandler, N., Rantanen, J., & Baldursdottir, S. (2017). The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro. Carbohydrate Polymers, 177, 433-442. https://doi.org/10.1016/j.carbpol.2017.08.135

Vancouver

Aho J, Halme A, Boetker J, Water JJ, Bohr A, Sandler N et al. The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro. Carbohydrate Polymers. 2017 Dec 1;177:433-442. https://doi.org/10.1016/j.carbpol.2017.08.135

Author

Aho, Johanna ; Halme, Amanda ; Boetker, Johan ; Water, Jorrit Jeroen ; Bohr, Adam ; Sandler, Niklas ; Rantanen, Jukka ; Baldursdottir, Stefania. / The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro. In: Carbohydrate Polymers. 2017 ; Vol. 177. pp. 433-442.

Bibtex

@article{ea8abf1390044d59bc1e3181b97bef66,

title = "The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro",

abstract = "Porous implants or implantable scaffolds used for tissue regeneration can encourage tissue growth inside the implant and provide extended drug release. Water-soluble polymers incorporated into a biodegradable or inert implant matrix may leach out upon contact with biological fluids and thereby gradually increasing the porosity of the implant and simultaneously release drug from the implant matrix. Different molecular weight grades of methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC) were mixed with polylactide and extruded into model implants containing nitrofurantoin as a model drug. The effect of the leached pore formers on the implant porosity and the rheology of the implant microenvironment in vitro was investigated and it was shown that HPMC pore formers had the greatest effect on the surrounding viscosity, with higher drug release and pore forming ability as compared to the MC pore formers. The highest molecular weight HPMC led to the most significant increase in viscosity of the implant microenvironment, while the highest drug release was achieved with the lowest molecular weight HPMC. The data suggested that the microenvironmental rheology of the implant, both in the formed pores and in biological fluids in the immediate vicinity of the implant could be an important factor affecting the diffusion of the drug and other molecules in the implantation site.",

keywords = "Journal Article",

author = "Johanna Aho and Amanda Halme and Johan Boetker and Water, {Jorrit Jeroen} and Adam Bohr and Niklas Sandler and Jukka Rantanen and Stefania Baldursdottir",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.carbpol.2017.08.135",

language = "English",

volume = "177",

pages = "433--442",

journal = "Carbohydrate Polymers",

issn = "0144-8617",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro

AU - Aho, Johanna

AU - Halme, Amanda

AU - Boetker, Johan

AU - Water, Jorrit Jeroen

AU - Bohr, Adam

AU - Sandler, Niklas

AU - Rantanen, Jukka

AU - Baldursdottir, Stefania

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Porous implants or implantable scaffolds used for tissue regeneration can encourage tissue growth inside the implant and provide extended drug release. Water-soluble polymers incorporated into a biodegradable or inert implant matrix may leach out upon contact with biological fluids and thereby gradually increasing the porosity of the implant and simultaneously release drug from the implant matrix. Different molecular weight grades of methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC) were mixed with polylactide and extruded into model implants containing nitrofurantoin as a model drug. The effect of the leached pore formers on the implant porosity and the rheology of the implant microenvironment in vitro was investigated and it was shown that HPMC pore formers had the greatest effect on the surrounding viscosity, with higher drug release and pore forming ability as compared to the MC pore formers. The highest molecular weight HPMC led to the most significant increase in viscosity of the implant microenvironment, while the highest drug release was achieved with the lowest molecular weight HPMC. The data suggested that the microenvironmental rheology of the implant, both in the formed pores and in biological fluids in the immediate vicinity of the implant could be an important factor affecting the diffusion of the drug and other molecules in the implantation site.

AB - Porous implants or implantable scaffolds used for tissue regeneration can encourage tissue growth inside the implant and provide extended drug release. Water-soluble polymers incorporated into a biodegradable or inert implant matrix may leach out upon contact with biological fluids and thereby gradually increasing the porosity of the implant and simultaneously release drug from the implant matrix. Different molecular weight grades of methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC) were mixed with polylactide and extruded into model implants containing nitrofurantoin as a model drug. The effect of the leached pore formers on the implant porosity and the rheology of the implant microenvironment in vitro was investigated and it was shown that HPMC pore formers had the greatest effect on the surrounding viscosity, with higher drug release and pore forming ability as compared to the MC pore formers. The highest molecular weight HPMC led to the most significant increase in viscosity of the implant microenvironment, while the highest drug release was achieved with the lowest molecular weight HPMC. The data suggested that the microenvironmental rheology of the implant, both in the formed pores and in biological fluids in the immediate vicinity of the implant could be an important factor affecting the diffusion of the drug and other molecules in the implantation site.

KW - Journal Article

U2 - 10.1016/j.carbpol.2017.08.135

DO - 10.1016/j.carbpol.2017.08.135

M3 - Journal article

C2 - 28962789

VL - 177

SP - 433

EP - 442

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

ER -

ID: 185403321

Department of Pharmacy