The characterization of fluidization behavior using a novel multichamber microscale fluid bed
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The characterization of fluidization behavior using a novel multichamber microscale fluid bed. / Räsänen, Eetu; Rantanen, Jukka; Mannermaa, Jukka-Pekka; Yliruusi, Jouko.
In: Journal of Pharmaceutical Sciences, Vol. 93, No. 3, 03.2004, p. 780-91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The characterization of fluidization behavior using a novel multichamber microscale fluid bed
AU - Räsänen, Eetu
AU - Rantanen, Jukka
AU - Mannermaa, Jukka-Pekka
AU - Yliruusi, Jouko
N1 - Copyright 2004 Wiley-Liss, Inc. and the American Pharmacists Association
PY - 2004/3
Y1 - 2004/3
N2 - In the preformulation stage, there is a special need to determine the process behavior of materials with smaller amounts of samples. The purpose of this study was to assemble a novel automated multichamber microscale fluid bed module with a process air control unit for the characterization of fluidization behavior in variable conditions. The results were evaluated on the basis of two common computational methods, the minimum fluidization velocity, and the Geldart classification. The materials studied were different particle sizes of glass beads, microcrystalline cellulose, and silicified microcrystalline cellulose. During processing, the different characteristic fluidization phases (e.g., plugging, bubbling, slugging, and turbulent fluidization) of the materials were observed by the pressure difference over the bed. When the moisture content of the process air was increased, the amount of free charge carriers increased and the fine glass beads fluidized on the limited range of velocity. The silicification was demonstrated to improve the fluidization behavior with two different particle sizes of cellulose powders. Due to the interparticle (e.g., electrostatic) forces of the fine solids, the utilization of the computational predictions was restricted. The presented setup is a novel approach for studying process behavior with only a few grams of materials.
AB - In the preformulation stage, there is a special need to determine the process behavior of materials with smaller amounts of samples. The purpose of this study was to assemble a novel automated multichamber microscale fluid bed module with a process air control unit for the characterization of fluidization behavior in variable conditions. The results were evaluated on the basis of two common computational methods, the minimum fluidization velocity, and the Geldart classification. The materials studied were different particle sizes of glass beads, microcrystalline cellulose, and silicified microcrystalline cellulose. During processing, the different characteristic fluidization phases (e.g., plugging, bubbling, slugging, and turbulent fluidization) of the materials were observed by the pressure difference over the bed. When the moisture content of the process air was increased, the amount of free charge carriers increased and the fine glass beads fluidized on the limited range of velocity. The silicification was demonstrated to improve the fluidization behavior with two different particle sizes of cellulose powders. Due to the interparticle (e.g., electrostatic) forces of the fine solids, the utilization of the computational predictions was restricted. The presented setup is a novel approach for studying process behavior with only a few grams of materials.
KW - Cellulose
KW - Glass
KW - Humidity
KW - Particle Size
KW - Phase Transition
KW - Powders
KW - Solubility
KW - Technology, Pharmaceutical
U2 - 10.1002/jps.10540
DO - 10.1002/jps.10540
M3 - Journal article
C2 - 14762915
VL - 93
SP - 780
EP - 791
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 3
ER -
ID: 140622135