The characterization of fluidization behavior using a novel multichamber microscale fluid bed

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

The characterization of fluidization behavior using a novel multichamber microscale fluid bed. / Räsänen, Eetu; Rantanen, Jukka; Mannermaa, Jukka-Pekka; Yliruusi, Jouko.

In: Journal of Pharmaceutical Sciences, Vol. 93, No. 3, 03.2004, p. 780-91.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Räsänen, E, Rantanen, J, Mannermaa, J-P & Yliruusi, J 2004, 'The characterization of fluidization behavior using a novel multichamber microscale fluid bed', Journal of Pharmaceutical Sciences, vol. 93, no. 3, pp. 780-91. https://doi.org/10.1002/jps.10540

APA

Räsänen, E., Rantanen, J., Mannermaa, J-P., & Yliruusi, J. (2004). The characterization of fluidization behavior using a novel multichamber microscale fluid bed. Journal of Pharmaceutical Sciences, 93(3), 780-91. https://doi.org/10.1002/jps.10540

Vancouver

Räsänen E, Rantanen J, Mannermaa J-P, Yliruusi J. The characterization of fluidization behavior using a novel multichamber microscale fluid bed. Journal of Pharmaceutical Sciences. 2004 Mar;93(3):780-91. https://doi.org/10.1002/jps.10540

Author

Räsänen, Eetu ; Rantanen, Jukka ; Mannermaa, Jukka-Pekka ; Yliruusi, Jouko. / The characterization of fluidization behavior using a novel multichamber microscale fluid bed. In: Journal of Pharmaceutical Sciences. 2004 ; Vol. 93, No. 3. pp. 780-91.

Bibtex

@article{7064f5fbae5949baa9eadce0365780f5,
title = "The characterization of fluidization behavior using a novel multichamber microscale fluid bed",
abstract = "In the preformulation stage, there is a special need to determine the process behavior of materials with smaller amounts of samples. The purpose of this study was to assemble a novel automated multichamber microscale fluid bed module with a process air control unit for the characterization of fluidization behavior in variable conditions. The results were evaluated on the basis of two common computational methods, the minimum fluidization velocity, and the Geldart classification. The materials studied were different particle sizes of glass beads, microcrystalline cellulose, and silicified microcrystalline cellulose. During processing, the different characteristic fluidization phases (e.g., plugging, bubbling, slugging, and turbulent fluidization) of the materials were observed by the pressure difference over the bed. When the moisture content of the process air was increased, the amount of free charge carriers increased and the fine glass beads fluidized on the limited range of velocity. The silicification was demonstrated to improve the fluidization behavior with two different particle sizes of cellulose powders. Due to the interparticle (e.g., electrostatic) forces of the fine solids, the utilization of the computational predictions was restricted. The presented setup is a novel approach for studying process behavior with only a few grams of materials.",
keywords = "Cellulose, Glass, Humidity, Particle Size, Phase Transition, Powders, Solubility, Technology, Pharmaceutical",
author = "Eetu R{\"a}s{\"a}nen and Jukka Rantanen and Jukka-Pekka Mannermaa and Jouko Yliruusi",
note = "Copyright 2004 Wiley-Liss, Inc. and the American Pharmacists Association",
year = "2004",
month = "3",
doi = "10.1002/jps.10540",
language = "English",
volume = "93",
pages = "780--91",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - The characterization of fluidization behavior using a novel multichamber microscale fluid bed

AU - Räsänen, Eetu

AU - Rantanen, Jukka

AU - Mannermaa, Jukka-Pekka

AU - Yliruusi, Jouko

N1 - Copyright 2004 Wiley-Liss, Inc. and the American Pharmacists Association

PY - 2004/3

Y1 - 2004/3

N2 - In the preformulation stage, there is a special need to determine the process behavior of materials with smaller amounts of samples. The purpose of this study was to assemble a novel automated multichamber microscale fluid bed module with a process air control unit for the characterization of fluidization behavior in variable conditions. The results were evaluated on the basis of two common computational methods, the minimum fluidization velocity, and the Geldart classification. The materials studied were different particle sizes of glass beads, microcrystalline cellulose, and silicified microcrystalline cellulose. During processing, the different characteristic fluidization phases (e.g., plugging, bubbling, slugging, and turbulent fluidization) of the materials were observed by the pressure difference over the bed. When the moisture content of the process air was increased, the amount of free charge carriers increased and the fine glass beads fluidized on the limited range of velocity. The silicification was demonstrated to improve the fluidization behavior with two different particle sizes of cellulose powders. Due to the interparticle (e.g., electrostatic) forces of the fine solids, the utilization of the computational predictions was restricted. The presented setup is a novel approach for studying process behavior with only a few grams of materials.

AB - In the preformulation stage, there is a special need to determine the process behavior of materials with smaller amounts of samples. The purpose of this study was to assemble a novel automated multichamber microscale fluid bed module with a process air control unit for the characterization of fluidization behavior in variable conditions. The results were evaluated on the basis of two common computational methods, the minimum fluidization velocity, and the Geldart classification. The materials studied were different particle sizes of glass beads, microcrystalline cellulose, and silicified microcrystalline cellulose. During processing, the different characteristic fluidization phases (e.g., plugging, bubbling, slugging, and turbulent fluidization) of the materials were observed by the pressure difference over the bed. When the moisture content of the process air was increased, the amount of free charge carriers increased and the fine glass beads fluidized on the limited range of velocity. The silicification was demonstrated to improve the fluidization behavior with two different particle sizes of cellulose powders. Due to the interparticle (e.g., electrostatic) forces of the fine solids, the utilization of the computational predictions was restricted. The presented setup is a novel approach for studying process behavior with only a few grams of materials.

KW - Cellulose

KW - Glass

KW - Humidity

KW - Particle Size

KW - Phase Transition

KW - Powders

KW - Solubility

KW - Technology, Pharmaceutical

U2 - 10.1002/jps.10540

DO - 10.1002/jps.10540

M3 - Journal article

C2 - 14762915

VL - 93

SP - 780

EP - 791

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 3

ER -

ID: 140622135