The biomolecular gastrointestinal corona in oral drug delivery

Research output: Contribution to journal › Review › Research › peer-review

Standard

The biomolecular gastrointestinal corona in oral drug delivery. / Aljabbari, Anas; Kihara, Shinji; Rades, Thomas; Boyd, Ben J.

In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 363, 2023, p. 536-549.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Aljabbari, A, Kihara, S, Rades, T & Boyd, BJ 2023, 'The biomolecular gastrointestinal corona in oral drug delivery', Journal of controlled release : official journal of the Controlled Release Society, vol. 363, pp. 536-549. https://doi.org/10.1016/j.jconrel.2023.09.049

APA

Aljabbari, A., Kihara, S., Rades, T., & Boyd, B. J. (2023). The biomolecular gastrointestinal corona in oral drug delivery. Journal of controlled release : official journal of the Controlled Release Society, 363, 536-549. https://doi.org/10.1016/j.jconrel.2023.09.049

Vancouver

Aljabbari A, Kihara S, Rades T, Boyd BJ. The biomolecular gastrointestinal corona in oral drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2023;363:536-549. https://doi.org/10.1016/j.jconrel.2023.09.049

Author

Aljabbari, Anas ; Kihara, Shinji ; Rades, Thomas ; Boyd, Ben J. / The biomolecular gastrointestinal corona in oral drug delivery. In: Journal of controlled release : official journal of the Controlled Release Society. 2023 ; Vol. 363. pp. 536-549.

Bibtex

@article{58e8b1cb769f406b95a72e7c2c3887d4,

title = "The biomolecular gastrointestinal corona in oral drug delivery",

abstract = "The formation of a biomolecular corona on exogenous particles in plasma is well studied and is known to dictate the biodistribution and cellular interactions of nanomedicine formulations. In contrast, while the oral route is the most favorable administration method for pharmaceuticals, little is known about the formation and composition of the corona formed by biomolecules on particles within the gastrointestinal tract. This work reviews the current literature understanding of (1) the formation of drug particles after oral administration, (2) the formation of a biomolecular corona within the gastrointestinal tract ({"}the gastrointestinal corona{"}), and (3) the possible implications of the formation of a gastrointestinal corona on the interactions of drug particles with their biological environment. In doing so, this work aims to establish the significance of the formation of a gastrointestinal corona in oral drug delivery to ultimately arrive at new avenues to control the behavior of orally administered pharmaceuticals.",

author = "Anas Aljabbari and Shinji Kihara and Thomas Rades and Boyd, {Ben J}",

year = "2023",

doi = "10.1016/j.jconrel.2023.09.049",

language = "English",

volume = "363",

pages = "536--549",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The biomolecular gastrointestinal corona in oral drug delivery

AU - Aljabbari, Anas

AU - Kihara, Shinji

AU - Rades, Thomas

AU - Boyd, Ben J

PY - 2023

Y1 - 2023

N2 - The formation of a biomolecular corona on exogenous particles in plasma is well studied and is known to dictate the biodistribution and cellular interactions of nanomedicine formulations. In contrast, while the oral route is the most favorable administration method for pharmaceuticals, little is known about the formation and composition of the corona formed by biomolecules on particles within the gastrointestinal tract. This work reviews the current literature understanding of (1) the formation of drug particles after oral administration, (2) the formation of a biomolecular corona within the gastrointestinal tract ("the gastrointestinal corona"), and (3) the possible implications of the formation of a gastrointestinal corona on the interactions of drug particles with their biological environment. In doing so, this work aims to establish the significance of the formation of a gastrointestinal corona in oral drug delivery to ultimately arrive at new avenues to control the behavior of orally administered pharmaceuticals.

AB - The formation of a biomolecular corona on exogenous particles in plasma is well studied and is known to dictate the biodistribution and cellular interactions of nanomedicine formulations. In contrast, while the oral route is the most favorable administration method for pharmaceuticals, little is known about the formation and composition of the corona formed by biomolecules on particles within the gastrointestinal tract. This work reviews the current literature understanding of (1) the formation of drug particles after oral administration, (2) the formation of a biomolecular corona within the gastrointestinal tract ("the gastrointestinal corona"), and (3) the possible implications of the formation of a gastrointestinal corona on the interactions of drug particles with their biological environment. In doing so, this work aims to establish the significance of the formation of a gastrointestinal corona in oral drug delivery to ultimately arrive at new avenues to control the behavior of orally administered pharmaceuticals.

U2 - 10.1016/j.jconrel.2023.09.049

DO - 10.1016/j.jconrel.2023.09.049

M3 - Review

C2 - 37776905

VL - 363

SP - 536

EP - 549

JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

ER -

ID: 369873124