Tailored beads made of dissolved cellulose - Investigation of their drug release properties
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Tailored beads made of dissolved cellulose - Investigation of their drug release properties. / Yildir, Emrah; Kolakovic, Ruzica; Genina, Natalja; Trygg, Jani; Gericke, Martin; Hanski, Leena; Ehlers, Henrik; Rantanen, Jukka; Tenho, Mikko; Vuorela, Pia; Fardim, Pedro; Sandler, Niklas.
In: International Journal of Pharmaceutics, Vol. 456, No. 2, 2013, p. 417-423.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Tailored beads made of dissolved cellulose - Investigation of their drug release properties
AU - Yildir, Emrah
AU - Kolakovic, Ruzica
AU - Genina, Natalja
AU - Trygg, Jani
AU - Gericke, Martin
AU - Hanski, Leena
AU - Ehlers, Henrik
AU - Rantanen, Jukka
AU - Tenho, Mikko
AU - Vuorela, Pia
AU - Fardim, Pedro
AU - Sandler, Niklas
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013
Y1 - 2013
N2 - In the frame of this work, we have investigated drug entrapping and release abilities of new type of porous cellulose beads (CBs) as a spherical matrix system for drug delivery. For that purpose, CBs prepared with three different methods were used as drug carriers and three compounds, anhydrous theophylline (Thp), riboflavin 5′-phosphate sodium (RSP) and lidocaine hydrochloride monohydrate (LiHCl) were used as model drug substances. The loading procedure was carried out by immersing swollen empty beads into the solutions of different concentrations of model drugs. The morphology of empty and loaded beads was examined using a field emission scanning electron microscopy (FE-SEM). Near-infrared (NIR) imaging was performed to identify the drug distributions on and within the loaded CBs. The drug amount incorporated into CBs was examined spectrophotometrically and in vitro drug release studies were performed to determine the drug release rates. The results of FE-SEM and chemical NIR imaging analyses revealed that incorporated drug were distributed on the surface and but also within the internal structure of the CBs. Physical properties of CBs and solubility of model drugs had effect on loading efficacy. Also, the drug release rates were controlled by solubility of model drugs (diffusion controlled release). In conclusion, CBs from dissolved cellulose show promise in achieving controlled drug delivery. © 2013 Elsevier B.V. All rights reserved.
AB - In the frame of this work, we have investigated drug entrapping and release abilities of new type of porous cellulose beads (CBs) as a spherical matrix system for drug delivery. For that purpose, CBs prepared with three different methods were used as drug carriers and three compounds, anhydrous theophylline (Thp), riboflavin 5′-phosphate sodium (RSP) and lidocaine hydrochloride monohydrate (LiHCl) were used as model drug substances. The loading procedure was carried out by immersing swollen empty beads into the solutions of different concentrations of model drugs. The morphology of empty and loaded beads was examined using a field emission scanning electron microscopy (FE-SEM). Near-infrared (NIR) imaging was performed to identify the drug distributions on and within the loaded CBs. The drug amount incorporated into CBs was examined spectrophotometrically and in vitro drug release studies were performed to determine the drug release rates. The results of FE-SEM and chemical NIR imaging analyses revealed that incorporated drug were distributed on the surface and but also within the internal structure of the CBs. Physical properties of CBs and solubility of model drugs had effect on loading efficacy. Also, the drug release rates were controlled by solubility of model drugs (diffusion controlled release). In conclusion, CBs from dissolved cellulose show promise in achieving controlled drug delivery. © 2013 Elsevier B.V. All rights reserved.
KW - Chemical imaging
KW - Drug delivery
KW - Drug loading
KW - Macrospheres
KW - Porous cellulose beads
U2 - 10.1016/j.ijpharm.2013.08.047
DO - 10.1016/j.ijpharm.2013.08.047
M3 - Journal article
C2 - 24012866
VL - 456
SP - 417
EP - 423
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 2
ER -
ID: 104836111