Synthesis of the thiazole-thiazoline fragment of largazole analogues

Research output: Contribution to journalJournal articleResearchpeer-review

The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.
Original languageEnglish
JournalJournal of Organic Chemistry
Issue number23
Pages (from-to)9845-9851
Publication statusPublished - 2 Dec 2011

ID: 35442124