Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms. / Huang, Zheng; Zhou, Tongchang; Yuan, Yuan; Klodziska, Sylvia Natalie; Zheng, Tao; Sternberg, Claus; Nielsen, Hanne Morck; Sun, Yi; Wan, Feng.

In: Journal of Colloid and Interface Science, Vol. 577, 2020, p. 66-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Huang, Z, Zhou, T, Yuan, Y, Klodziska, SN, Zheng, T, Sternberg, C, Nielsen, HM, Sun, Y & Wan, F 2020, 'Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms', Journal of Colloid and Interface Science, vol. 577, pp. 66-74. https://doi.org/10.1016/j.jcis.2020.05.067

APA

Huang, Z., Zhou, T., Yuan, Y., Klodziska, S. N., Zheng, T., Sternberg, C., Nielsen, H. M., Sun, Y., & Wan, F. (2020). Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms. Journal of Colloid and Interface Science, 577, 66-74. https://doi.org/10.1016/j.jcis.2020.05.067

Vancouver

Huang Z, Zhou T, Yuan Y, Klodziska SN, Zheng T, Sternberg C et al. Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms. Journal of Colloid and Interface Science. 2020;577:66-74. https://doi.org/10.1016/j.jcis.2020.05.067

Author

Huang, Zheng ; Zhou, Tongchang ; Yuan, Yuan ; Klodziska, Sylvia Natalie ; Zheng, Tao ; Sternberg, Claus ; Nielsen, Hanne Morck ; Sun, Yi ; Wan, Feng. / Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms. In: Journal of Colloid and Interface Science. 2020 ; Vol. 577. pp. 66-74.

Bibtex

@article{cfa68e23e0864fe7af322460d602d14a,
title = "Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms",
abstract = "Bacterial biofilm represents a protected mode of bacterial growth that significantly enhances the resistance to antibiotics. Poly lactic-co-glycolic acid (PLGA)-based nanoparticle delivery systems have been intensively investigated to combat the bacterial biofilms-associated infections. However, some drawbacks associated with current PLGA-based nanoformulations (e.g. the relatively low drug loading capability, premature burst release and/or incapability of on-demand release of cargos at the site of action) restrict the transition from the lab research to the clinical applications. One potent strategy to overcome the above-mentioned limitations is exploiting the unique properties of carbon quantum dots (CQDs) and combining CQDs with the conventional PLGA nanoparticles. In the present study, the CQDs were innovatively incorporated into PLGA nanoparticles by using a microfluidic method. The resulting CQD-PLGA hybrid nanoparticles presented good loading capability of azithromycin (a macrolide antibiotic, AZI) and tobramycin (an aminoglycoside antibiotic, TOB), and stimuli-responsive release of the cargos upon laser irradiation. Consequently, AZI-loaded CQD-PLGA hybrid nanoparticles showed chemo-photothermally synergistic anti-biofilm effects against P. aeruginosa biofilms. Additionally, the CQD-PLGA hybrid nanoparticles demonstrated good biocompatibility with the eukaryotic cells. Overall, the proof-of-concept of CQD-PLGA hybrid nanoparticles may open a new possibility in chemophotothermal therapy against bacterial biofilms. (C) 2020 Elsevier Inc. All rights reserved.",
keywords = "Carbon quantum dots, PLGA nanoparticles, Chemo-photothermal therapy, Bacterial biofilms, Azithromycin, Tobramycin, PSEUDOMONAS-AERUGINOSA BIOFILMS, PLGA-BASED NANOPARTICLES, DRUG-DELIVERY, MICROPARTICLES, ANTIBIOTICS, PARADIGM, RELEASE",
author = "Zheng Huang and Tongchang Zhou and Yuan Yuan and Klodziska, {Sylvia Natalie} and Tao Zheng and Claus Sternberg and Nielsen, {Hanne Morck} and Yi Sun and Feng Wan",
year = "2020",
doi = "10.1016/j.jcis.2020.05.067",
language = "English",
volume = "577",
pages = "66--74",
journal = "Journal of Colloid and Interface Science",
issn = "0021-9797",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms

AU - Huang, Zheng

AU - Zhou, Tongchang

AU - Yuan, Yuan

AU - Klodziska, Sylvia Natalie

AU - Zheng, Tao

AU - Sternberg, Claus

AU - Nielsen, Hanne Morck

AU - Sun, Yi

AU - Wan, Feng

PY - 2020

Y1 - 2020

N2 - Bacterial biofilm represents a protected mode of bacterial growth that significantly enhances the resistance to antibiotics. Poly lactic-co-glycolic acid (PLGA)-based nanoparticle delivery systems have been intensively investigated to combat the bacterial biofilms-associated infections. However, some drawbacks associated with current PLGA-based nanoformulations (e.g. the relatively low drug loading capability, premature burst release and/or incapability of on-demand release of cargos at the site of action) restrict the transition from the lab research to the clinical applications. One potent strategy to overcome the above-mentioned limitations is exploiting the unique properties of carbon quantum dots (CQDs) and combining CQDs with the conventional PLGA nanoparticles. In the present study, the CQDs were innovatively incorporated into PLGA nanoparticles by using a microfluidic method. The resulting CQD-PLGA hybrid nanoparticles presented good loading capability of azithromycin (a macrolide antibiotic, AZI) and tobramycin (an aminoglycoside antibiotic, TOB), and stimuli-responsive release of the cargos upon laser irradiation. Consequently, AZI-loaded CQD-PLGA hybrid nanoparticles showed chemo-photothermally synergistic anti-biofilm effects against P. aeruginosa biofilms. Additionally, the CQD-PLGA hybrid nanoparticles demonstrated good biocompatibility with the eukaryotic cells. Overall, the proof-of-concept of CQD-PLGA hybrid nanoparticles may open a new possibility in chemophotothermal therapy against bacterial biofilms. (C) 2020 Elsevier Inc. All rights reserved.

AB - Bacterial biofilm represents a protected mode of bacterial growth that significantly enhances the resistance to antibiotics. Poly lactic-co-glycolic acid (PLGA)-based nanoparticle delivery systems have been intensively investigated to combat the bacterial biofilms-associated infections. However, some drawbacks associated with current PLGA-based nanoformulations (e.g. the relatively low drug loading capability, premature burst release and/or incapability of on-demand release of cargos at the site of action) restrict the transition from the lab research to the clinical applications. One potent strategy to overcome the above-mentioned limitations is exploiting the unique properties of carbon quantum dots (CQDs) and combining CQDs with the conventional PLGA nanoparticles. In the present study, the CQDs were innovatively incorporated into PLGA nanoparticles by using a microfluidic method. The resulting CQD-PLGA hybrid nanoparticles presented good loading capability of azithromycin (a macrolide antibiotic, AZI) and tobramycin (an aminoglycoside antibiotic, TOB), and stimuli-responsive release of the cargos upon laser irradiation. Consequently, AZI-loaded CQD-PLGA hybrid nanoparticles showed chemo-photothermally synergistic anti-biofilm effects against P. aeruginosa biofilms. Additionally, the CQD-PLGA hybrid nanoparticles demonstrated good biocompatibility with the eukaryotic cells. Overall, the proof-of-concept of CQD-PLGA hybrid nanoparticles may open a new possibility in chemophotothermal therapy against bacterial biofilms. (C) 2020 Elsevier Inc. All rights reserved.

KW - Carbon quantum dots

KW - PLGA nanoparticles

KW - Chemo-photothermal therapy

KW - Bacterial biofilms

KW - Azithromycin

KW - Tobramycin

KW - PSEUDOMONAS-AERUGINOSA BIOFILMS

KW - PLGA-BASED NANOPARTICLES

KW - DRUG-DELIVERY

KW - MICROPARTICLES

KW - ANTIBIOTICS

KW - PARADIGM

KW - RELEASE

U2 - 10.1016/j.jcis.2020.05.067

DO - 10.1016/j.jcis.2020.05.067

M3 - Journal article

C2 - 32473477

VL - 577

SP - 66

EP - 74

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

SN - 0021-9797

ER -

ID: 248894262