Studying Microstructure in Molecular Crystals With Nanoindentation: Intergrowth Polymorphism in Felodipine
Research output: Contribution to journal › Journal article › Research › peer-review
Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.
Original language | English |
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Journal | Angewandte Chemie (International ed. in English) |
Volume | 53 |
Issue number | 48 |
Pages (from-to) | 13102-13105 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 26 Sep 2014 |
ID: 124945871