Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. / Holm, René; Porter, Christopher J H; Müllertz, Anette; Kristensen, Henning G; Charman, William N.

In: Pharmaceutical Research, Vol. 19, No. 9, 2002, p. 1354-61.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Holm, R, Porter, CJH, Müllertz, A, Kristensen, HG & Charman, WN 2002, 'Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats', Pharmaceutical Research, vol. 19, no. 9, pp. 1354-61.

APA

Holm, R., Porter, C. J. H., Müllertz, A., Kristensen, H. G., & Charman, W. N. (2002). Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. Pharmaceutical Research, 19(9), 1354-61.

Vancouver

Holm R, Porter CJH, Müllertz A, Kristensen HG, Charman WN. Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. Pharmaceutical Research. 2002;19(9):1354-61.

Author

Holm, René ; Porter, Christopher J H ; Müllertz, Anette ; Kristensen, Henning G ; Charman, William N. / Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. In: Pharmaceutical Research. 2002 ; Vol. 19, No. 9. pp. 1354-61.

Bibtex

@article{f0b03890c5eb11dd9473000ea68e967b,
title = "Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats",
abstract = "PURPOSE: To compare the influence of triglyceride vehicle intramolecular structure on the intestinal lymphatic transport and systemic absorption of halofantrine in conscious rats. METHODS: Conscious, lymph cannulated and nonlymph cannulated rats were dosed orally with three structurally different triglycerides; sunflower oil, and two structured triglycerides containing different proportion and position of medium-(M) and long-chain (L) fatty acids on the glycerol backbone. The two structured triglycerides were abbreviated MLM and LML to reflect the structural position on the glycerol. The concentration of halofantrine in blood and lymph samples was analyzed by HPLC. RESULTS: Both the lymphatic transport and the total absorption of halofantrine were enhanced by the use the MLM triglyceride. The estimated total absorption of halofantrine in the lymph cannulated animals was higher than in the nonlymph cannulated animals, and this was most pronounced for the animals dosed with the structured triglycerides. CONCLUSIONS: Using MLM as vehicle increases the portal absorption of halofantrine and results in similar lymphatic transport levels when compared to sunflower oil. Total absorption when assessed as absorption in the blood plus lymphatic transport for halofantrine after administration in the MLM triglyceride was higher than after administration in sunflower oil.",
author = "Ren{\'e} Holm and Porter, {Christopher J H} and Anette M{\"u}llertz and Kristensen, {Henning G} and Charman, {William N}",
note = "Keywords: Administration, Oral; Animals; Biological Availability; Drug Delivery Systems; Intestines; Lymph; Lymphatic System; Phenanthrenes; Rats; Triglycerides; Vehicles",
year = "2002",
language = "English",
volume = "19",
pages = "1354--61",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

AU - Holm, René

AU - Porter, Christopher J H

AU - Müllertz, Anette

AU - Kristensen, Henning G

AU - Charman, William N

N1 - Keywords: Administration, Oral; Animals; Biological Availability; Drug Delivery Systems; Intestines; Lymph; Lymphatic System; Phenanthrenes; Rats; Triglycerides; Vehicles

PY - 2002

Y1 - 2002

N2 - PURPOSE: To compare the influence of triglyceride vehicle intramolecular structure on the intestinal lymphatic transport and systemic absorption of halofantrine in conscious rats. METHODS: Conscious, lymph cannulated and nonlymph cannulated rats were dosed orally with three structurally different triglycerides; sunflower oil, and two structured triglycerides containing different proportion and position of medium-(M) and long-chain (L) fatty acids on the glycerol backbone. The two structured triglycerides were abbreviated MLM and LML to reflect the structural position on the glycerol. The concentration of halofantrine in blood and lymph samples was analyzed by HPLC. RESULTS: Both the lymphatic transport and the total absorption of halofantrine were enhanced by the use the MLM triglyceride. The estimated total absorption of halofantrine in the lymph cannulated animals was higher than in the nonlymph cannulated animals, and this was most pronounced for the animals dosed with the structured triglycerides. CONCLUSIONS: Using MLM as vehicle increases the portal absorption of halofantrine and results in similar lymphatic transport levels when compared to sunflower oil. Total absorption when assessed as absorption in the blood plus lymphatic transport for halofantrine after administration in the MLM triglyceride was higher than after administration in sunflower oil.

AB - PURPOSE: To compare the influence of triglyceride vehicle intramolecular structure on the intestinal lymphatic transport and systemic absorption of halofantrine in conscious rats. METHODS: Conscious, lymph cannulated and nonlymph cannulated rats were dosed orally with three structurally different triglycerides; sunflower oil, and two structured triglycerides containing different proportion and position of medium-(M) and long-chain (L) fatty acids on the glycerol backbone. The two structured triglycerides were abbreviated MLM and LML to reflect the structural position on the glycerol. The concentration of halofantrine in blood and lymph samples was analyzed by HPLC. RESULTS: Both the lymphatic transport and the total absorption of halofantrine were enhanced by the use the MLM triglyceride. The estimated total absorption of halofantrine in the lymph cannulated animals was higher than in the nonlymph cannulated animals, and this was most pronounced for the animals dosed with the structured triglycerides. CONCLUSIONS: Using MLM as vehicle increases the portal absorption of halofantrine and results in similar lymphatic transport levels when compared to sunflower oil. Total absorption when assessed as absorption in the blood plus lymphatic transport for halofantrine after administration in the MLM triglyceride was higher than after administration in sunflower oil.

M3 - Journal article

C2 - 12403073

VL - 19

SP - 1354

EP - 1361

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 9

ER -

ID: 9013012