Solid-state interactions between trimethoprim and parabens

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Solid-state interactions between trimethoprim and the esters of 4-hydroxybenzoic acid (parahydroxybenzoates or parabens) used for anti-microbial preservation are investigated. The formation of a crystalline 1/1 molecular compound between trimethoprim and methyl parahydroxybenzoate is demonstrated by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and solid-state C-13-NMR. Interactions between trimethoprim and 4-hydroxybenzoic acid and its ethyl,propyl and butyl esters were not observed. The nature of the trimethoprim and methyl parahydroxybenzoate intermolecular bonding is discussed briefly.
Original languageUndefined/Unknown
JournalSTP pharma sciences
Issue number4
Pages (from-to)292-297
Number of pages6
Publication statusPublished - 1994

ID: 38062149