Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids. / Wei, Wei; Lu, Xiaonan; Wang, Zegao; Pérez, Bianca; Liu, Jingying; Wu, Chengyu; Dong, Mingdong; Feng, Fengqin; Mu, Huiling; Guo, Zheng.

In: Journal of Colloid and Interface Science, Vol. 505, 01.11.2017, p. 392-401.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wei, W, Lu, X, Wang, Z, Pérez, B, Liu, J, Wu, C, Dong, M, Feng, F, Mu, H & Guo, Z 2017, 'Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids', Journal of Colloid and Interface Science, vol. 505, pp. 392-401. https://doi.org/10.1016/j.jcis.2017.06.022

APA

Wei, W., Lu, X., Wang, Z., Pérez, B., Liu, J., Wu, C., Dong, M., Feng, F., Mu, H., & Guo, Z. (2017). Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids. Journal of Colloid and Interface Science, 505, 392-401. https://doi.org/10.1016/j.jcis.2017.06.022

Vancouver

Wei W, Lu X, Wang Z, Pérez B, Liu J, Wu C et al. Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids. Journal of Colloid and Interface Science. 2017 Nov 1;505:392-401. https://doi.org/10.1016/j.jcis.2017.06.022

Author

Wei, Wei ; Lu, Xiaonan ; Wang, Zegao ; Pérez, Bianca ; Liu, Jingying ; Wu, Chengyu ; Dong, Mingdong ; Feng, Fengqin ; Mu, Huiling ; Guo, Zheng. / Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids. In: Journal of Colloid and Interface Science. 2017 ; Vol. 505. pp. 392-401.

Bibtex

@article{ee0358bf5e8441d098057079e7222e5e,

title = "Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids",

abstract = "HYPOTHESIS: Synthetic sugar alcohol mono-behenates with high melting points, surface activity and resistance to enzymatic lipolysis, are expected to form stable single-component solid lipid nanocarriers (SC-SLNs). The preparation methods and the polar head group of the molecules should affect the size and drug encapsulation efficiency.EXPERIMENTS: SC-SLNs of sugar alcohol mono-behenates with varied polar heads were prepared using emulsification-diffusion method and melting-probe sonication method. Model lipophilic drug fenofibrate was formulated into nanocarriers. The drug release was assessed using the lipolysis model. The structure and drug distribution of the nanocarriers were studied using AFM and TEM.FINDINGS: Both the polar head group of the molecules and the preparation methods affect the particle size and size distribution. Nanocarriers prepared with sorbitol mono-behenates showed the smallest mean size (∼100nm with PdI of 0.26). In addition, they displayed high entrapment efficiency of fenofibrate (95%) and long term drug release. Nanocarriers prepared by emulsification-diffusion method entrapped fenofibrate into lipid bilayers. In contrast, Nanocarriers prepared by melting-probe sonication method had a micelle structure with fenofibrate incorporated into a lipid monolayer. This study provides an insight into the systematic development of novel amphiphilic lipids for solid lipid-based drug delivery system.",

keywords = "Journal Article",

author = "Wei Wei and Xiaonan Lu and Zegao Wang and Bianca P{\'e}rez and Jingying Liu and Chengyu Wu and Mingdong Dong and Fengqin Feng and Huiling Mu and Zheng Guo",

year = "2017",

month = nov,

day = "1",

doi = "10.1016/j.jcis.2017.06.022",

language = "English",

volume = "505",

pages = "392--401",

journal = "Journal of Colloid and Interface Science",

issn = "0021-9797",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Single-component solid lipid nanocarriers prepared with ultra-long chain amphiphilic lipids

AU - Wei, Wei

AU - Lu, Xiaonan

AU - Wang, Zegao

AU - Pérez, Bianca

AU - Liu, Jingying

AU - Wu, Chengyu

AU - Dong, Mingdong

AU - Feng, Fengqin

AU - Mu, Huiling

AU - Guo, Zheng

PY - 2017/11/1

Y1 - 2017/11/1

N2 - HYPOTHESIS: Synthetic sugar alcohol mono-behenates with high melting points, surface activity and resistance to enzymatic lipolysis, are expected to form stable single-component solid lipid nanocarriers (SC-SLNs). The preparation methods and the polar head group of the molecules should affect the size and drug encapsulation efficiency.EXPERIMENTS: SC-SLNs of sugar alcohol mono-behenates with varied polar heads were prepared using emulsification-diffusion method and melting-probe sonication method. Model lipophilic drug fenofibrate was formulated into nanocarriers. The drug release was assessed using the lipolysis model. The structure and drug distribution of the nanocarriers were studied using AFM and TEM.FINDINGS: Both the polar head group of the molecules and the preparation methods affect the particle size and size distribution. Nanocarriers prepared with sorbitol mono-behenates showed the smallest mean size (∼100nm with PdI of 0.26). In addition, they displayed high entrapment efficiency of fenofibrate (95%) and long term drug release. Nanocarriers prepared by emulsification-diffusion method entrapped fenofibrate into lipid bilayers. In contrast, Nanocarriers prepared by melting-probe sonication method had a micelle structure with fenofibrate incorporated into a lipid monolayer. This study provides an insight into the systematic development of novel amphiphilic lipids for solid lipid-based drug delivery system.

AB - HYPOTHESIS: Synthetic sugar alcohol mono-behenates with high melting points, surface activity and resistance to enzymatic lipolysis, are expected to form stable single-component solid lipid nanocarriers (SC-SLNs). The preparation methods and the polar head group of the molecules should affect the size and drug encapsulation efficiency.EXPERIMENTS: SC-SLNs of sugar alcohol mono-behenates with varied polar heads were prepared using emulsification-diffusion method and melting-probe sonication method. Model lipophilic drug fenofibrate was formulated into nanocarriers. The drug release was assessed using the lipolysis model. The structure and drug distribution of the nanocarriers were studied using AFM and TEM.FINDINGS: Both the polar head group of the molecules and the preparation methods affect the particle size and size distribution. Nanocarriers prepared with sorbitol mono-behenates showed the smallest mean size (∼100nm with PdI of 0.26). In addition, they displayed high entrapment efficiency of fenofibrate (95%) and long term drug release. Nanocarriers prepared by emulsification-diffusion method entrapped fenofibrate into lipid bilayers. In contrast, Nanocarriers prepared by melting-probe sonication method had a micelle structure with fenofibrate incorporated into a lipid monolayer. This study provides an insight into the systematic development of novel amphiphilic lipids for solid lipid-based drug delivery system.

KW - Journal Article

U2 - 10.1016/j.jcis.2017.06.022

DO - 10.1016/j.jcis.2017.06.022

M3 - Journal article

C2 - 28623698

VL - 505

SP - 392

EP - 401

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

SN - 0021-9797

ER -

ID: 182659831

Department of Pharmacy