Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties. / Hansen, Frederik Andre; Tirandaz, Shima; Pedersen-Bjergaard, Stig.

In: Journal of Separation Science, Vol. 44, No. 13, 2021, p. 2631-2641.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, FA, Tirandaz, S & Pedersen-Bjergaard, S 2021, 'Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties', Journal of Separation Science, vol. 44, no. 13, pp. 2631-2641. https://doi.org/10.1002/jssc.202100167

APA

Hansen, F. A., Tirandaz, S., & Pedersen-Bjergaard, S. (2021). Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties. Journal of Separation Science, 44(13), 2631-2641. https://doi.org/10.1002/jssc.202100167

Vancouver

Hansen FA, Tirandaz S, Pedersen-Bjergaard S. Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties. Journal of Separation Science. 2021;44(13):2631-2641. https://doi.org/10.1002/jssc.202100167

Author

Hansen, Frederik Andre ; Tirandaz, Shima ; Pedersen-Bjergaard, Stig. / Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties. In: Journal of Separation Science. 2021 ; Vol. 44, No. 13. pp. 2631-2641.

Bibtex

@article{7028848dd9ff4202bd721ab2267b7b3e,
title = "Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties",
abstract = "In the present fundamental study, selectivity and efficiency of electromembrane extraction of 50 polar basic substances (-6.7 P < +1.0) was systematically studied for ten different supported liquid membranes. For each model substance, 23 molecular descriptors were collected and these were investigated as potential parameters for understanding of extraction efficiency and selectivity by means of partial least squares regression. Overall, a highly aromatic deep eutectic solvent composed of coumarin and thymol with addition of 2% ionic carrier (di(2-ethylhexyl) phosphate) provided the highest extraction efficiency with an average extraction yield of 69% from pure water samples, 55% from plasma, and 62% from urine. With this solvent system, ionic, cation-pi, and pi-pi interactions between the supported liquid membrane and analytes were dominant. Supported liquid membranes without aromaticity, however, operated primarily based on hydrogen-bonding interactions. This is the first time the relationship between analyte properties, solvent composition, and extraction yield has systematically been studied for polar bases in electromembrane extraction. This new knowledge represents a first step toward enabling future development and optimization of electromembrane extraction systems for polar bases based on rational design, rather than trial-and-error approaches.",
keywords = "deep eutectic solvents, electromembrane extraction, partial least square regression, polar bases, sample preparation, BASIC DRUGS, CAPILLARY-ELECTROPHORESIS, ELECTROKINETIC MIGRATION, PLASMA, SAMPLES, PH",
author = "Hansen, {Frederik Andre} and Shima Tirandaz and Stig Pedersen-Bjergaard",
year = "2021",
doi = "10.1002/jssc.202100167",
language = "English",
volume = "44",
pages = "2631--2641",
journal = "HRC &amp; CC, Journal of High Resolution Chromatography and Chromatography Communications",
issn = "1615-9306",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "13",

}

RIS

TY - JOUR

T1 - Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes-Link to analyte properties

AU - Hansen, Frederik Andre

AU - Tirandaz, Shima

AU - Pedersen-Bjergaard, Stig

PY - 2021

Y1 - 2021

N2 - In the present fundamental study, selectivity and efficiency of electromembrane extraction of 50 polar basic substances (-6.7 P < +1.0) was systematically studied for ten different supported liquid membranes. For each model substance, 23 molecular descriptors were collected and these were investigated as potential parameters for understanding of extraction efficiency and selectivity by means of partial least squares regression. Overall, a highly aromatic deep eutectic solvent composed of coumarin and thymol with addition of 2% ionic carrier (di(2-ethylhexyl) phosphate) provided the highest extraction efficiency with an average extraction yield of 69% from pure water samples, 55% from plasma, and 62% from urine. With this solvent system, ionic, cation-pi, and pi-pi interactions between the supported liquid membrane and analytes were dominant. Supported liquid membranes without aromaticity, however, operated primarily based on hydrogen-bonding interactions. This is the first time the relationship between analyte properties, solvent composition, and extraction yield has systematically been studied for polar bases in electromembrane extraction. This new knowledge represents a first step toward enabling future development and optimization of electromembrane extraction systems for polar bases based on rational design, rather than trial-and-error approaches.

AB - In the present fundamental study, selectivity and efficiency of electromembrane extraction of 50 polar basic substances (-6.7 P < +1.0) was systematically studied for ten different supported liquid membranes. For each model substance, 23 molecular descriptors were collected and these were investigated as potential parameters for understanding of extraction efficiency and selectivity by means of partial least squares regression. Overall, a highly aromatic deep eutectic solvent composed of coumarin and thymol with addition of 2% ionic carrier (di(2-ethylhexyl) phosphate) provided the highest extraction efficiency with an average extraction yield of 69% from pure water samples, 55% from plasma, and 62% from urine. With this solvent system, ionic, cation-pi, and pi-pi interactions between the supported liquid membrane and analytes were dominant. Supported liquid membranes without aromaticity, however, operated primarily based on hydrogen-bonding interactions. This is the first time the relationship between analyte properties, solvent composition, and extraction yield has systematically been studied for polar bases in electromembrane extraction. This new knowledge represents a first step toward enabling future development and optimization of electromembrane extraction systems for polar bases based on rational design, rather than trial-and-error approaches.

KW - deep eutectic solvents

KW - electromembrane extraction

KW - partial least square regression

KW - polar bases

KW - sample preparation

KW - BASIC DRUGS

KW - CAPILLARY-ELECTROPHORESIS

KW - ELECTROKINETIC MIGRATION

KW - PLASMA

KW - SAMPLES

KW - PH

U2 - 10.1002/jssc.202100167

DO - 10.1002/jssc.202100167

M3 - Journal article

C2 - 33909952

VL - 44

SP - 2631

EP - 2641

JO - HRC &amp; CC, Journal of High Resolution Chromatography and Chromatography Communications

JF - HRC &amp; CC, Journal of High Resolution Chromatography and Chromatography Communications

SN - 1615-9306

IS - 13

ER -

ID: 272375031