Salt effects in electromembrane extraction

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Salt effects in electromembrane extraction. / Seip, Knut Fredrik; Jensen, Henrik; Kieu, Thanh Elisabeth; Gjelstad, Astrid; Pedersen-Bjergaard, Stig.

In: Journal of Chromatography A, Vol. 1347, 20.06.2014, p. 1-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Seip, KF, Jensen, H, Kieu, TE, Gjelstad, A & Pedersen-Bjergaard, S 2014, 'Salt effects in electromembrane extraction', Journal of Chromatography A, vol. 1347, pp. 1-7. https://doi.org/10.1016/j.chroma.2014.04.053

APA

Seip, K. F., Jensen, H., Kieu, T. E., Gjelstad, A., & Pedersen-Bjergaard, S. (2014). Salt effects in electromembrane extraction. Journal of Chromatography A, 1347, 1-7. https://doi.org/10.1016/j.chroma.2014.04.053

Vancouver

Seip KF, Jensen H, Kieu TE, Gjelstad A, Pedersen-Bjergaard S. Salt effects in electromembrane extraction. Journal of Chromatography A. 2014 Jun 20;1347:1-7. https://doi.org/10.1016/j.chroma.2014.04.053

Author

Seip, Knut Fredrik ; Jensen, Henrik ; Kieu, Thanh Elisabeth ; Gjelstad, Astrid ; Pedersen-Bjergaard, Stig. / Salt effects in electromembrane extraction. In: Journal of Chromatography A. 2014 ; Vol. 1347. pp. 1-7.

Bibtex

@article{8bb12ef8c8cb4af48fc4b31e93b9405f,

title = "Salt effects in electromembrane extraction",

abstract = "Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical chemical properties were used as model analytes. When EME was performed in a hollow fiber setup with a supported liquid membrane (SLM) comprised of 2-nitrophenyl octyl ether (NPOE), a substantial reduction in recovery was seen for eight of the substances when 2.5% (w/v) NaCl was present. No correlation between this loss and the physical chemical properties of these substances was seen. The recovery loss was hypothesized to be caused by ion pairing in the SLM, and a mathematical model for the extraction recovery in the presence of salts was made according to the experimental observations. Some variations to the EME system reduced this recovery loss, such as changing the SLM solvent from NPOE to 6-undecanone, or by using a different EME setup with more favorable volume ratios. This was in line with the ion pairing hypothesis and the mathematical model. This thorough investigation of how salts affect EME improves the theoretical understanding of the extraction process, and can contribute to the future development and optimization of the technique.",

keywords = "Chromatography, High Pressure Liquid, Electricity, Electrophoresis, Capillary, Ethers, Liquid-Liquid Extraction, Membranes, Artificial, Pharmaceutical Preparations, Sodium Chloride, Solvents, Sulfates",

author = "Seip, {Knut Fredrik} and Henrik Jensen and Kieu, {Thanh Elisabeth} and Astrid Gjelstad and Stig Pedersen-Bjergaard",

year = "2014",

month = jun,

day = "20",

doi = "10.1016/j.chroma.2014.04.053",

language = "English",

volume = "1347",

pages = "1--7",

journal = "Journal of Chromatography",

issn = "0301-4770",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Salt effects in electromembrane extraction

AU - Seip, Knut Fredrik

AU - Jensen, Henrik

AU - Kieu, Thanh Elisabeth

AU - Gjelstad, Astrid

AU - Pedersen-Bjergaard, Stig

PY - 2014/6/20

Y1 - 2014/6/20

N2 - Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical chemical properties were used as model analytes. When EME was performed in a hollow fiber setup with a supported liquid membrane (SLM) comprised of 2-nitrophenyl octyl ether (NPOE), a substantial reduction in recovery was seen for eight of the substances when 2.5% (w/v) NaCl was present. No correlation between this loss and the physical chemical properties of these substances was seen. The recovery loss was hypothesized to be caused by ion pairing in the SLM, and a mathematical model for the extraction recovery in the presence of salts was made according to the experimental observations. Some variations to the EME system reduced this recovery loss, such as changing the SLM solvent from NPOE to 6-undecanone, or by using a different EME setup with more favorable volume ratios. This was in line with the ion pairing hypothesis and the mathematical model. This thorough investigation of how salts affect EME improves the theoretical understanding of the extraction process, and can contribute to the future development and optimization of the technique.

AB - Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical chemical properties were used as model analytes. When EME was performed in a hollow fiber setup with a supported liquid membrane (SLM) comprised of 2-nitrophenyl octyl ether (NPOE), a substantial reduction in recovery was seen for eight of the substances when 2.5% (w/v) NaCl was present. No correlation between this loss and the physical chemical properties of these substances was seen. The recovery loss was hypothesized to be caused by ion pairing in the SLM, and a mathematical model for the extraction recovery in the presence of salts was made according to the experimental observations. Some variations to the EME system reduced this recovery loss, such as changing the SLM solvent from NPOE to 6-undecanone, or by using a different EME setup with more favorable volume ratios. This was in line with the ion pairing hypothesis and the mathematical model. This thorough investigation of how salts affect EME improves the theoretical understanding of the extraction process, and can contribute to the future development and optimization of the technique.

KW - Chromatography, High Pressure Liquid

KW - Electricity

KW - Electrophoresis, Capillary

KW - Ethers

KW - Liquid-Liquid Extraction

KW - Membranes, Artificial

KW - Pharmaceutical Preparations

KW - Sodium Chloride

KW - Solvents

KW - Sulfates

U2 - 10.1016/j.chroma.2014.04.053

DO - 10.1016/j.chroma.2014.04.053

M3 - Journal article

C2 - 24792700

VL - 1347

SP - 1

EP - 7

JO - Journal of Chromatography

JF - Journal of Chromatography

SN - 0301-4770

ER -

ID: 120792578