Rheology as a tool for evaluation of melt processability of innovative dosage forms

Research output: Contribution to journalJournal article

Standard

Rheology as a tool for evaluation of melt processability of innovative dosage forms. / Aho, Johanna Maaria; Boetker, Johan P; Baldursdottir, Stefania; Rantanen, Jukka.

In: International Journal of Pharmaceutics, Vol. 494, No. 2, 30.10.2015, p. 623–642.

Research output: Contribution to journalJournal article

Harvard

Aho, JM, Boetker, JP, Baldursdottir, S & Rantanen, J 2015, 'Rheology as a tool for evaluation of melt processability of innovative dosage forms', International Journal of Pharmaceutics, vol. 494, no. 2, pp. 623–642. https://doi.org/10.1016/j.ijpharm.2015.02.009

APA

Aho, J. M., Boetker, J. P., Baldursdottir, S., & Rantanen, J. (2015). Rheology as a tool for evaluation of melt processability of innovative dosage forms. International Journal of Pharmaceutics, 494(2), 623–642. https://doi.org/10.1016/j.ijpharm.2015.02.009

Vancouver

Aho JM, Boetker JP, Baldursdottir S, Rantanen J. Rheology as a tool for evaluation of melt processability of innovative dosage forms. International Journal of Pharmaceutics. 2015 Oct 30;494(2): 623–642. https://doi.org/10.1016/j.ijpharm.2015.02.009

Author

Aho, Johanna Maaria ; Boetker, Johan P ; Baldursdottir, Stefania ; Rantanen, Jukka. / Rheology as a tool for evaluation of melt processability of innovative dosage forms. In: International Journal of Pharmaceutics. 2015 ; Vol. 494, No. 2. pp. 623–642.

Bibtex

@article{fc556b6059d94ed1b1694d8d20f00150,
title = "Rheology as a tool for evaluation of melt processability of innovative dosage forms",
abstract = "Future manufacturing of pharmaceuticals will involve innovative use of polymeric excipients. Hot melt extrusion (HME) is an already established manufacturing technique and several products based on HME are on the market. Additionally, processing based on, e.g., HME or three dimensional (3D) printing, will have an increasingly important role when designing products for flexible dosing, since dosage forms based on compacting of a given powder mixture do not enable manufacturing of optimal pharmaceutical products for personalized treatments. The melt processability of polymers and API-polymer mixtures is highly dependent on the rheological properties of these systems, and rheological measurements should be considered as a more central part of the material characterization tool box when selecting suitable candidates for melt processing by, e.g., HME or 3D printing. The polymer processing industry offers established platforms, methods, and models for rheological characterization, and they can often be readily applied in the field of pharmaceutical manufacturing. Thoroughly measured and calculated rheological parameters together with thermal and mechanical material data are needed for the process simulations which are also becoming increasingly important. The authors aim to give an overview to the basics of rheology and summarize examples of the studies where rheology has been utilized in setting up or evaluating extrusion processes. Furthermore, examples of different experimental set-ups available for rheological measurements are presented, discussing each of their typical application area, advantages and limitations.",
author = "Aho, {Johanna Maaria} and Boetker, {Johan P} and Stefania Baldursdottir and Jukka Rantanen",
note = "Copyright {\circledC} 2015 Elsevier B.V. All rights reserved.",
year = "2015",
month = "10",
day = "30",
doi = "10.1016/j.ijpharm.2015.02.009",
language = "English",
volume = "494",
pages = "623–642",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Rheology as a tool for evaluation of melt processability of innovative dosage forms

AU - Aho, Johanna Maaria

AU - Boetker, Johan P

AU - Baldursdottir, Stefania

AU - Rantanen, Jukka

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Future manufacturing of pharmaceuticals will involve innovative use of polymeric excipients. Hot melt extrusion (HME) is an already established manufacturing technique and several products based on HME are on the market. Additionally, processing based on, e.g., HME or three dimensional (3D) printing, will have an increasingly important role when designing products for flexible dosing, since dosage forms based on compacting of a given powder mixture do not enable manufacturing of optimal pharmaceutical products for personalized treatments. The melt processability of polymers and API-polymer mixtures is highly dependent on the rheological properties of these systems, and rheological measurements should be considered as a more central part of the material characterization tool box when selecting suitable candidates for melt processing by, e.g., HME or 3D printing. The polymer processing industry offers established platforms, methods, and models for rheological characterization, and they can often be readily applied in the field of pharmaceutical manufacturing. Thoroughly measured and calculated rheological parameters together with thermal and mechanical material data are needed for the process simulations which are also becoming increasingly important. The authors aim to give an overview to the basics of rheology and summarize examples of the studies where rheology has been utilized in setting up or evaluating extrusion processes. Furthermore, examples of different experimental set-ups available for rheological measurements are presented, discussing each of their typical application area, advantages and limitations.

AB - Future manufacturing of pharmaceuticals will involve innovative use of polymeric excipients. Hot melt extrusion (HME) is an already established manufacturing technique and several products based on HME are on the market. Additionally, processing based on, e.g., HME or three dimensional (3D) printing, will have an increasingly important role when designing products for flexible dosing, since dosage forms based on compacting of a given powder mixture do not enable manufacturing of optimal pharmaceutical products for personalized treatments. The melt processability of polymers and API-polymer mixtures is highly dependent on the rheological properties of these systems, and rheological measurements should be considered as a more central part of the material characterization tool box when selecting suitable candidates for melt processing by, e.g., HME or 3D printing. The polymer processing industry offers established platforms, methods, and models for rheological characterization, and they can often be readily applied in the field of pharmaceutical manufacturing. Thoroughly measured and calculated rheological parameters together with thermal and mechanical material data are needed for the process simulations which are also becoming increasingly important. The authors aim to give an overview to the basics of rheology and summarize examples of the studies where rheology has been utilized in setting up or evaluating extrusion processes. Furthermore, examples of different experimental set-ups available for rheological measurements are presented, discussing each of their typical application area, advantages and limitations.

U2 - 10.1016/j.ijpharm.2015.02.009

DO - 10.1016/j.ijpharm.2015.02.009

M3 - Journal article

VL - 494

SP - 623

EP - 642

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -

ID: 131826862